Bone Metastases from Gastric Cancer Resembling Paget's Disease: A Case Report
Systemic osteosclerotic lesions are frequently caused by multiple bone metastases or systemic metabolic disorders. However, bone metastasis from gastric cancer is rare. Herein, we describe such a case, with radiographic and clinical findings resembling Paget's disease. The patient was an 80-yea...
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| Veröffentlicht in: | Journal of clinical medicine 2022-12, Vol.11 (24), p.7306 |
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| creator | Aiba, Hisaki Nakazato, Tomoharu Matsuo, Hideo Kimura, Hiroaki Saito, Shiro Sakai, Takao Murakami, Hideki Kawai, Jun Kawasaki, Shingo Imamura, Yasuhiro |
| description | Systemic osteosclerotic lesions are frequently caused by multiple bone metastases or systemic metabolic disorders. However, bone metastasis from gastric cancer is rare. Herein, we describe such a case, with radiographic and clinical findings resembling Paget's disease. The patient was an 80-year-old Japanese woman with a history of early gastric cancer, treated by partial gastrectomy 2 years prior. The patient sought medical care for chronic low back pain. On imaging, systemic sclerotic lesions were observed throughout the spine and pelvis, with an increase in bone mineral density from 0.86 g/cm
(2 years prior) to 1.38g/cm
(current visit) in the lumbar spine. Elevated serum levels of osteoblastic and osteolytic markers were identified. A bone biopsy was used to confirm the diagnosis of metastatic gastric cancer. The patient was treated with TS-1 and denosumab, with normalization of abnormal metabolic markers and alleviation of the back pain. Bone metastasis is reported in only 10% of cases of gastric cancer and, thus, is relatively rare. Therefore, our case of gastric cancer recurrence presenting with mixed osteoblastic and osteolytic bone lesions similar to Paget's disease is relevant to the report. Bone biopsy is necessary for an accurate diagnosis. |
| doi_str_mv | 10.3390/jcm11247306 |
| format | Article |
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(2 years prior) to 1.38g/cm
(current visit) in the lumbar spine. Elevated serum levels of osteoblastic and osteolytic markers were identified. A bone biopsy was used to confirm the diagnosis of metastatic gastric cancer. The patient was treated with TS-1 and denosumab, with normalization of abnormal metabolic markers and alleviation of the back pain. Bone metastasis is reported in only 10% of cases of gastric cancer and, thus, is relatively rare. Therefore, our case of gastric cancer recurrence presenting with mixed osteoblastic and osteolytic bone lesions similar to Paget's disease is relevant to the report. Bone biopsy is necessary for an accurate diagnosis.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm11247306</identifier><identifier>PMID: 36555923</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Back pain ; Biopsy ; Bone density ; Bones ; Case Report ; Case reports ; Ethics ; Gastric cancer ; Growth factors ; Medical prognosis ; Metabolism ; Metastasis ; Phosphatase ; Tumors ; Vertebrae</subject><ispartof>Journal of clinical medicine, 2022-12, Vol.11 (24), p.7306</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-7d08411bab9285251551b16df320af6126204da8939efad37e2fc28d22b2947a3</citedby><cites>FETCH-LOGICAL-c372t-7d08411bab9285251551b16df320af6126204da8939efad37e2fc28d22b2947a3</cites><orcidid>0000-0002-3438-9814</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784664/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784664/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36555923$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aiba, Hisaki</creatorcontrib><creatorcontrib>Nakazato, Tomoharu</creatorcontrib><creatorcontrib>Matsuo, Hideo</creatorcontrib><creatorcontrib>Kimura, Hiroaki</creatorcontrib><creatorcontrib>Saito, Shiro</creatorcontrib><creatorcontrib>Sakai, Takao</creatorcontrib><creatorcontrib>Murakami, Hideki</creatorcontrib><creatorcontrib>Kawai, Jun</creatorcontrib><creatorcontrib>Kawasaki, Shingo</creatorcontrib><creatorcontrib>Imamura, Yasuhiro</creatorcontrib><title>Bone Metastases from Gastric Cancer Resembling Paget's Disease: A Case Report</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Systemic osteosclerotic lesions are frequently caused by multiple bone metastases or systemic metabolic disorders. However, bone metastasis from gastric cancer is rare. Herein, we describe such a case, with radiographic and clinical findings resembling Paget's disease. The patient was an 80-year-old Japanese woman with a history of early gastric cancer, treated by partial gastrectomy 2 years prior. The patient sought medical care for chronic low back pain. On imaging, systemic sclerotic lesions were observed throughout the spine and pelvis, with an increase in bone mineral density from 0.86 g/cm
(2 years prior) to 1.38g/cm
(current visit) in the lumbar spine. Elevated serum levels of osteoblastic and osteolytic markers were identified. A bone biopsy was used to confirm the diagnosis of metastatic gastric cancer. The patient was treated with TS-1 and denosumab, with normalization of abnormal metabolic markers and alleviation of the back pain. Bone metastasis is reported in only 10% of cases of gastric cancer and, thus, is relatively rare. Therefore, our case of gastric cancer recurrence presenting with mixed osteoblastic and osteolytic bone lesions similar to Paget's disease is relevant to the report. Bone biopsy is necessary for an accurate diagnosis.</description><subject>Back pain</subject><subject>Biopsy</subject><subject>Bone density</subject><subject>Bones</subject><subject>Case Report</subject><subject>Case reports</subject><subject>Ethics</subject><subject>Gastric cancer</subject><subject>Growth factors</subject><subject>Medical prognosis</subject><subject>Metabolism</subject><subject>Metastasis</subject><subject>Phosphatase</subject><subject>Tumors</subject><subject>Vertebrae</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpVkE1LAzEQhoMottSevEvAgwdZTSabj_Ug1PoJLYroOWR3s3VLd1OTreC_N9Ja6jAwM8zDO8OL0DElF4xl5HJeNJRCKhkRe6gPRMqEMMX2d_oeGoYwJzGUSoHKQ9RjgnOeAeuj6Y1rLZ7azoSYNuDKuwY_xMnXBR6btrAev9pgm3xRtzP8Yma2Owv4tg428ld4FKFgI7J0vjtCB5VZBDvc1AF6v797Gz8mk-eHp_FokhRMQpfIkqiU0tzkGSgOnHJOcyrKigExlaAggKSlURnLbGVKJi1UBagSIIcslYYN0PVad7nKG1sWtu28Weilrxvjv7Uztf6_aesPPXNfOpMqFSKNAqcbAe8-VzZ0eu5Wvo0_a5BcSKCKqEidr6nCuxC8rbYXKNG_9usd-yN9svvUlv0zm_0Ay-V-4A</recordid><startdate>20221209</startdate><enddate>20221209</enddate><creator>Aiba, Hisaki</creator><creator>Nakazato, Tomoharu</creator><creator>Matsuo, Hideo</creator><creator>Kimura, Hiroaki</creator><creator>Saito, Shiro</creator><creator>Sakai, Takao</creator><creator>Murakami, Hideki</creator><creator>Kawai, Jun</creator><creator>Kawasaki, Shingo</creator><creator>Imamura, Yasuhiro</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3438-9814</orcidid></search><sort><creationdate>20221209</creationdate><title>Bone Metastases from Gastric Cancer Resembling Paget's Disease: A Case Report</title><author>Aiba, Hisaki ; Nakazato, Tomoharu ; Matsuo, Hideo ; Kimura, Hiroaki ; Saito, Shiro ; Sakai, Takao ; Murakami, Hideki ; Kawai, Jun ; Kawasaki, Shingo ; Imamura, Yasuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-7d08411bab9285251551b16df320af6126204da8939efad37e2fc28d22b2947a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Back pain</topic><topic>Biopsy</topic><topic>Bone density</topic><topic>Bones</topic><topic>Case Report</topic><topic>Case reports</topic><topic>Ethics</topic><topic>Gastric cancer</topic><topic>Growth factors</topic><topic>Medical prognosis</topic><topic>Metabolism</topic><topic>Metastasis</topic><topic>Phosphatase</topic><topic>Tumors</topic><topic>Vertebrae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aiba, Hisaki</creatorcontrib><creatorcontrib>Nakazato, Tomoharu</creatorcontrib><creatorcontrib>Matsuo, Hideo</creatorcontrib><creatorcontrib>Kimura, Hiroaki</creatorcontrib><creatorcontrib>Saito, Shiro</creatorcontrib><creatorcontrib>Sakai, Takao</creatorcontrib><creatorcontrib>Murakami, Hideki</creatorcontrib><creatorcontrib>Kawai, Jun</creatorcontrib><creatorcontrib>Kawasaki, Shingo</creatorcontrib><creatorcontrib>Imamura, Yasuhiro</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aiba, Hisaki</au><au>Nakazato, Tomoharu</au><au>Matsuo, Hideo</au><au>Kimura, Hiroaki</au><au>Saito, Shiro</au><au>Sakai, Takao</au><au>Murakami, Hideki</au><au>Kawai, Jun</au><au>Kawasaki, Shingo</au><au>Imamura, Yasuhiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone Metastases from Gastric Cancer Resembling Paget's Disease: A Case Report</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2022-12-09</date><risdate>2022</risdate><volume>11</volume><issue>24</issue><spage>7306</spage><pages>7306-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Systemic osteosclerotic lesions are frequently caused by multiple bone metastases or systemic metabolic disorders. 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(2 years prior) to 1.38g/cm
(current visit) in the lumbar spine. Elevated serum levels of osteoblastic and osteolytic markers were identified. A bone biopsy was used to confirm the diagnosis of metastatic gastric cancer. The patient was treated with TS-1 and denosumab, with normalization of abnormal metabolic markers and alleviation of the back pain. Bone metastasis is reported in only 10% of cases of gastric cancer and, thus, is relatively rare. Therefore, our case of gastric cancer recurrence presenting with mixed osteoblastic and osteolytic bone lesions similar to Paget's disease is relevant to the report. Bone biopsy is necessary for an accurate diagnosis.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36555923</pmid><doi>10.3390/jcm11247306</doi><orcidid>https://orcid.org/0000-0002-3438-9814</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Back pain Biopsy Bone density Bones Case Report Case reports Ethics Gastric cancer Growth factors Medical prognosis Metabolism Metastasis Phosphatase Tumors Vertebrae |
| title | Bone Metastases from Gastric Cancer Resembling Paget's Disease: A Case Report |
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