Prediagnosis Depression Rather Than Anxiety Symptoms Is Associated with Decreased Ovarian Cancer Survival: Findings from the Ovarian Cancer Follow-Up Study (OOPS)
Background: The relationship between prediagnosis depression, anxiety symptoms, and ovarian cancer (OC) survival is unknown. We aimed to explore these associations to provide further epidemiological evidence. Methods: We investigated the relationship between prediagnosis depression, anxiety symptoms...
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| Veröffentlicht in: | Journal of clinical medicine 2022-12, Vol.11 (24), p.7394 |
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| creator | Li, Yi-Zi Qin, Xue Liu, Fang-Hua Chen, Wen-Xiao Wei, Yi-Fan Wang, Na Yan, Shi Kang, Ye Zhao, Yu-Hong Gao, Song Gong, Ting-Ting Wu, Qi-Jun |
| description | Background: The relationship between prediagnosis depression, anxiety symptoms, and ovarian cancer (OC) survival is unknown. We aimed to explore these associations to provide further epidemiological evidence. Methods: We investigated the relationship between prediagnosis depression, anxiety symptoms, and OC survival in a prospective cohort study of newly diagnosed OC patients aged 18−79 years. Depression and anxiety symptoms were assessed using the Patient Health Questionnaire 9 and Generalized Anxiety Disorder 7 at diagnosis, respectively. Deaths were ascertained until 31 March 2021 via medical records and active follow-up. Multivariable-adjusted Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) with prediagnosis depression and anxiety symptoms and all-cause mortality of OC. Results: We found 56 (9.4%) and 235 (39.3%) OC patients with depression and anxiety symptoms, respectively. During a median follow-up of 37.2 months (interquartile range 24.7−50.2 months), 130 deaths were confirmed. Compared with non-depression symptoms, patients with prediagnosis depressive symptoms showed a significantly increased risk of OC mortality (HR = 2.10, 95% CI: 1.20−3.70). Of note, the association was still robust when focusing on the OC patients with severe depressive symptoms (HR = 2.10, 95% CI: 1.07−4.12). However, we observed no association between prediagnosis anxiety symptoms of different severity and OC mortality. Interestingly, OC patients with combined moderate depression and anxiety symptoms had a significantly increased risk of OC mortality (HR = 3.23, 95% CI: 1.14−9.11) compared to those with no symptoms of depression and anxiety. Notably, Wilms’s tumor 1 was significantly associated with depression and anxiety symptoms (p < 0.05). Conclusions: Prediagnosis depression increases the risk of OC mortality. Large multicenter studies are required to confirm this finding. |
| doi_str_mv | 10.3390/jcm11247394 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9781310</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2756724455</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-35e37cdc1ad5c4c209d395c58cc0a2992b1ee32e28b7eaf0fc1c9c623f03bc9f3</originalsourceid><addsrcrecordid>eNpdkU1r3DAQhk1oSEKaU-9F0EtKcKsP27J6KCzbbhsIbOgmZ6Mdj3e12JIj2Zvu38kvrULSsIkuIzHPPIx4k-QDo1-EUPTrBjrGeCaFyg6SE06lTKkoxbu9-3FyFsKGxlOWGWfyKDkWRZ4XlKqT5OHaY230yrpgAvmBvccQjLPkjx7W6MnNWlsysX8NDjuy2HX94LpALgOZhODA6AFrcm-GdRwFjzrE53yrvYlTU20hGhaj35qtbr-RmbG1satAGu86EvVv0ZlrW3ef3vZkMYz1jpzP59eLz--Tw0a3Ac-e62lyO_t5M_2dXs1_XU4nVylkVA2pyFFIqIHpOocMOFW1UDnkJQDVXCm-ZIiCIy-XEnVDG2CgoOCioWIJqhGnyfcnbz8uO6wB7eB1W_XedNrvKqdN9bpjzbpauW2lZMkEo1Fw_izw7m7EMFSdCYBtqy26MVRc5iVVqih5RD-9QTdu9DZ-75EqJM-yPI_UxRMF3oXgsXlZhtHqMf5qL_5If9zf_4X9H7b4B4Rurc8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2756724455</pqid></control><display><type>article</type><title>Prediagnosis Depression Rather Than Anxiety Symptoms Is Associated with Decreased Ovarian Cancer Survival: Findings from the Ovarian Cancer Follow-Up Study (OOPS)</title><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Li, Yi-Zi ; Qin, Xue ; Liu, Fang-Hua ; Chen, Wen-Xiao ; Wei, Yi-Fan ; Wang, Na ; Yan, Shi ; Kang, Ye ; Zhao, Yu-Hong ; Gao, Song ; Gong, Ting-Ting ; Wu, Qi-Jun</creator><creatorcontrib>Li, Yi-Zi ; Qin, Xue ; Liu, Fang-Hua ; Chen, Wen-Xiao ; Wei, Yi-Fan ; Wang, Na ; Yan, Shi ; Kang, Ye ; Zhao, Yu-Hong ; Gao, Song ; Gong, Ting-Ting ; Wu, Qi-Jun</creatorcontrib><description>Background: The relationship between prediagnosis depression, anxiety symptoms, and ovarian cancer (OC) survival is unknown. We aimed to explore these associations to provide further epidemiological evidence. Methods: We investigated the relationship between prediagnosis depression, anxiety symptoms, and OC survival in a prospective cohort study of newly diagnosed OC patients aged 18−79 years. Depression and anxiety symptoms were assessed using the Patient Health Questionnaire 9 and Generalized Anxiety Disorder 7 at diagnosis, respectively. Deaths were ascertained until 31 March 2021 via medical records and active follow-up. Multivariable-adjusted Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) with prediagnosis depression and anxiety symptoms and all-cause mortality of OC. Results: We found 56 (9.4%) and 235 (39.3%) OC patients with depression and anxiety symptoms, respectively. During a median follow-up of 37.2 months (interquartile range 24.7−50.2 months), 130 deaths were confirmed. Compared with non-depression symptoms, patients with prediagnosis depressive symptoms showed a significantly increased risk of OC mortality (HR = 2.10, 95% CI: 1.20−3.70). Of note, the association was still robust when focusing on the OC patients with severe depressive symptoms (HR = 2.10, 95% CI: 1.07−4.12). However, we observed no association between prediagnosis anxiety symptoms of different severity and OC mortality. Interestingly, OC patients with combined moderate depression and anxiety symptoms had a significantly increased risk of OC mortality (HR = 3.23, 95% CI: 1.14−9.11) compared to those with no symptoms of depression and anxiety. Notably, Wilms’s tumor 1 was significantly associated with depression and anxiety symptoms (p < 0.05). Conclusions: Prediagnosis depression increases the risk of OC mortality. Large multicenter studies are required to confirm this finding.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm11247394</identifier><identifier>PMID: 36556009</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Cardiovascular disease ; Clinical medicine ; Cohort analysis ; Generalized anxiety disorder ; Hospitals ; Medical prognosis ; Mental depression ; Mental disorders ; Mortality ; Ovarian cancer ; Patients ; Questionnaires ; Sleep ; Vital statistics</subject><ispartof>Journal of clinical medicine, 2022-12, Vol.11 (24), p.7394</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-35e37cdc1ad5c4c209d395c58cc0a2992b1ee32e28b7eaf0fc1c9c623f03bc9f3</citedby><cites>FETCH-LOGICAL-c409t-35e37cdc1ad5c4c209d395c58cc0a2992b1ee32e28b7eaf0fc1c9c623f03bc9f3</cites><orcidid>0000-0003-0806-4247 ; 0000-0002-6350-106X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781310/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781310/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36556009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Yi-Zi</creatorcontrib><creatorcontrib>Qin, Xue</creatorcontrib><creatorcontrib>Liu, Fang-Hua</creatorcontrib><creatorcontrib>Chen, Wen-Xiao</creatorcontrib><creatorcontrib>Wei, Yi-Fan</creatorcontrib><creatorcontrib>Wang, Na</creatorcontrib><creatorcontrib>Yan, Shi</creatorcontrib><creatorcontrib>Kang, Ye</creatorcontrib><creatorcontrib>Zhao, Yu-Hong</creatorcontrib><creatorcontrib>Gao, Song</creatorcontrib><creatorcontrib>Gong, Ting-Ting</creatorcontrib><creatorcontrib>Wu, Qi-Jun</creatorcontrib><title>Prediagnosis Depression Rather Than Anxiety Symptoms Is Associated with Decreased Ovarian Cancer Survival: Findings from the Ovarian Cancer Follow-Up Study (OOPS)</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Background: The relationship between prediagnosis depression, anxiety symptoms, and ovarian cancer (OC) survival is unknown. We aimed to explore these associations to provide further epidemiological evidence. Methods: We investigated the relationship between prediagnosis depression, anxiety symptoms, and OC survival in a prospective cohort study of newly diagnosed OC patients aged 18−79 years. Depression and anxiety symptoms were assessed using the Patient Health Questionnaire 9 and Generalized Anxiety Disorder 7 at diagnosis, respectively. Deaths were ascertained until 31 March 2021 via medical records and active follow-up. Multivariable-adjusted Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) with prediagnosis depression and anxiety symptoms and all-cause mortality of OC. Results: We found 56 (9.4%) and 235 (39.3%) OC patients with depression and anxiety symptoms, respectively. During a median follow-up of 37.2 months (interquartile range 24.7−50.2 months), 130 deaths were confirmed. Compared with non-depression symptoms, patients with prediagnosis depressive symptoms showed a significantly increased risk of OC mortality (HR = 2.10, 95% CI: 1.20−3.70). Of note, the association was still robust when focusing on the OC patients with severe depressive symptoms (HR = 2.10, 95% CI: 1.07−4.12). However, we observed no association between prediagnosis anxiety symptoms of different severity and OC mortality. Interestingly, OC patients with combined moderate depression and anxiety symptoms had a significantly increased risk of OC mortality (HR = 3.23, 95% CI: 1.14−9.11) compared to those with no symptoms of depression and anxiety. Notably, Wilms’s tumor 1 was significantly associated with depression and anxiety symptoms (p < 0.05). Conclusions: Prediagnosis depression increases the risk of OC mortality. Large multicenter studies are required to confirm this finding.</description><subject>Cardiovascular disease</subject><subject>Clinical medicine</subject><subject>Cohort analysis</subject><subject>Generalized anxiety disorder</subject><subject>Hospitals</subject><subject>Medical prognosis</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Mortality</subject><subject>Ovarian cancer</subject><subject>Patients</subject><subject>Questionnaires</subject><subject>Sleep</subject><subject>Vital statistics</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkU1r3DAQhk1oSEKaU-9F0EtKcKsP27J6KCzbbhsIbOgmZ6Mdj3e12JIj2Zvu38kvrULSsIkuIzHPPIx4k-QDo1-EUPTrBjrGeCaFyg6SE06lTKkoxbu9-3FyFsKGxlOWGWfyKDkWRZ4XlKqT5OHaY230yrpgAvmBvccQjLPkjx7W6MnNWlsysX8NDjuy2HX94LpALgOZhODA6AFrcm-GdRwFjzrE53yrvYlTU20hGhaj35qtbr-RmbG1satAGu86EvVv0ZlrW3ef3vZkMYz1jpzP59eLz--Tw0a3Ac-e62lyO_t5M_2dXs1_XU4nVylkVA2pyFFIqIHpOocMOFW1UDnkJQDVXCm-ZIiCIy-XEnVDG2CgoOCioWIJqhGnyfcnbz8uO6wB7eB1W_XedNrvKqdN9bpjzbpauW2lZMkEo1Fw_izw7m7EMFSdCYBtqy26MVRc5iVVqih5RD-9QTdu9DZ-75EqJM-yPI_UxRMF3oXgsXlZhtHqMf5qL_5If9zf_4X9H7b4B4Rurc8</recordid><startdate>20221213</startdate><enddate>20221213</enddate><creator>Li, Yi-Zi</creator><creator>Qin, Xue</creator><creator>Liu, Fang-Hua</creator><creator>Chen, Wen-Xiao</creator><creator>Wei, Yi-Fan</creator><creator>Wang, Na</creator><creator>Yan, Shi</creator><creator>Kang, Ye</creator><creator>Zhao, Yu-Hong</creator><creator>Gao, Song</creator><creator>Gong, Ting-Ting</creator><creator>Wu, Qi-Jun</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0806-4247</orcidid><orcidid>https://orcid.org/0000-0002-6350-106X</orcidid></search><sort><creationdate>20221213</creationdate><title>Prediagnosis Depression Rather Than Anxiety Symptoms Is Associated with Decreased Ovarian Cancer Survival: Findings from the Ovarian Cancer Follow-Up Study (OOPS)</title><author>Li, Yi-Zi ; Qin, Xue ; Liu, Fang-Hua ; Chen, Wen-Xiao ; Wei, Yi-Fan ; Wang, Na ; Yan, Shi ; Kang, Ye ; Zhao, Yu-Hong ; Gao, Song ; Gong, Ting-Ting ; Wu, Qi-Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-35e37cdc1ad5c4c209d395c58cc0a2992b1ee32e28b7eaf0fc1c9c623f03bc9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cardiovascular disease</topic><topic>Clinical medicine</topic><topic>Cohort analysis</topic><topic>Generalized anxiety disorder</topic><topic>Hospitals</topic><topic>Medical prognosis</topic><topic>Mental depression</topic><topic>Mental disorders</topic><topic>Mortality</topic><topic>Ovarian cancer</topic><topic>Patients</topic><topic>Questionnaires</topic><topic>Sleep</topic><topic>Vital statistics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yi-Zi</creatorcontrib><creatorcontrib>Qin, Xue</creatorcontrib><creatorcontrib>Liu, Fang-Hua</creatorcontrib><creatorcontrib>Chen, Wen-Xiao</creatorcontrib><creatorcontrib>Wei, Yi-Fan</creatorcontrib><creatorcontrib>Wang, Na</creatorcontrib><creatorcontrib>Yan, Shi</creatorcontrib><creatorcontrib>Kang, Ye</creatorcontrib><creatorcontrib>Zhao, Yu-Hong</creatorcontrib><creatorcontrib>Gao, Song</creatorcontrib><creatorcontrib>Gong, Ting-Ting</creatorcontrib><creatorcontrib>Wu, Qi-Jun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yi-Zi</au><au>Qin, Xue</au><au>Liu, Fang-Hua</au><au>Chen, Wen-Xiao</au><au>Wei, Yi-Fan</au><au>Wang, Na</au><au>Yan, Shi</au><au>Kang, Ye</au><au>Zhao, Yu-Hong</au><au>Gao, Song</au><au>Gong, Ting-Ting</au><au>Wu, Qi-Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediagnosis Depression Rather Than Anxiety Symptoms Is Associated with Decreased Ovarian Cancer Survival: Findings from the Ovarian Cancer Follow-Up Study (OOPS)</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2022-12-13</date><risdate>2022</risdate><volume>11</volume><issue>24</issue><spage>7394</spage><pages>7394-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Background: The relationship between prediagnosis depression, anxiety symptoms, and ovarian cancer (OC) survival is unknown. We aimed to explore these associations to provide further epidemiological evidence. Methods: We investigated the relationship between prediagnosis depression, anxiety symptoms, and OC survival in a prospective cohort study of newly diagnosed OC patients aged 18−79 years. Depression and anxiety symptoms were assessed using the Patient Health Questionnaire 9 and Generalized Anxiety Disorder 7 at diagnosis, respectively. Deaths were ascertained until 31 March 2021 via medical records and active follow-up. Multivariable-adjusted Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) with prediagnosis depression and anxiety symptoms and all-cause mortality of OC. Results: We found 56 (9.4%) and 235 (39.3%) OC patients with depression and anxiety symptoms, respectively. During a median follow-up of 37.2 months (interquartile range 24.7−50.2 months), 130 deaths were confirmed. Compared with non-depression symptoms, patients with prediagnosis depressive symptoms showed a significantly increased risk of OC mortality (HR = 2.10, 95% CI: 1.20−3.70). Of note, the association was still robust when focusing on the OC patients with severe depressive symptoms (HR = 2.10, 95% CI: 1.07−4.12). However, we observed no association between prediagnosis anxiety symptoms of different severity and OC mortality. Interestingly, OC patients with combined moderate depression and anxiety symptoms had a significantly increased risk of OC mortality (HR = 3.23, 95% CI: 1.14−9.11) compared to those with no symptoms of depression and anxiety. Notably, Wilms’s tumor 1 was significantly associated with depression and anxiety symptoms (p < 0.05). Conclusions: Prediagnosis depression increases the risk of OC mortality. Large multicenter studies are required to confirm this finding.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36556009</pmid><doi>10.3390/jcm11247394</doi><orcidid>https://orcid.org/0000-0003-0806-4247</orcidid><orcidid>https://orcid.org/0000-0002-6350-106X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Cardiovascular disease Clinical medicine Cohort analysis Generalized anxiety disorder Hospitals Medical prognosis Mental depression Mental disorders Mortality Ovarian cancer Patients Questionnaires Sleep Vital statistics |
| title | Prediagnosis Depression Rather Than Anxiety Symptoms Is Associated with Decreased Ovarian Cancer Survival: Findings from the Ovarian Cancer Follow-Up Study (OOPS) |
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