Increased Intestinal Permeability and Stool Zonulin, Calprotectin and Beta-Defensin-2 Concentrations in Allogenic Hematopoietic Cell Transplantation Recipients

Significant progress has been made in understanding the connection between intestinal barrier function and allogenic hematopoietic cell transplantation (allo-HCT) recipients' outcomes. The purpose of this study was to further evaluate gut barrier permeability and other potential intestinal barr...

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Veröffentlicht in:International journal of molecular sciences 2022-12, Vol.23 (24), p.15962
Hauptverfasser: Tyszka, Martyna, Maciejewska-Markiewicz, Dominika, Biliński, Jarosław, Lubas, Arkadiusz, Stachowska, Ewa, Basak, Grzegorz W
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container_issue 24
container_start_page 15962
container_title International journal of molecular sciences
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creator Tyszka, Martyna
Maciejewska-Markiewicz, Dominika
Biliński, Jarosław
Lubas, Arkadiusz
Stachowska, Ewa
Basak, Grzegorz W
description Significant progress has been made in understanding the connection between intestinal barrier function and allogenic hematopoietic cell transplantation (allo-HCT) recipients' outcomes. The purpose of this study was to further evaluate gut barrier permeability and other potential intestinal barrier disruption markers in the allo-HCT setting. Fifty-one patients were enrolled in the study. Intestinal permeability was assessed with the sugar absorption test and faecal concentrations of the zonulin, calprotectin and beta-defensin-2 levels in the peri-transplantation period. Most patients undergoing allo-HCT in our department had a disrupted intestinal barrier at the baseline, which was associated with older age and higher Hematopoietic Cell Transplantation-specific Comorbidity Index (HCT-CI). Regardless of this, we observed a further increase in gut barrier permeability after allo-HCT in most patients. However, there was no association between permeability assay and other markers (zonulin, calprotectin and beta-defensin-2). Patients with acute GVHD had significantly higher median calprotectin concentrations after allo-HCT compared with the patients without this complication. Our findings indicate that gut barrier damage develops prior to allo-HCT with progression after the procedure and precedes further complications, but did not prove other markers to be useful surrogates of intestinal permeability.
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subjects Autoimmune diseases
Bacterial infections
beta-Defensins
Biomarkers
Comorbidity
Defensins
Digestive system
Feces
Graft versus host disease
Graft vs Host Disease - etiology
Graft-versus-host reaction
Hematopoietic Stem Cell Transplantation - adverse effects
Hematopoietic Stem Cell Transplantation - methods
Humans
Immune system
Infections
Intestine
Kinases
Mucositis
Pathogens
Patients
Permeability
Stem cell transplantation
Transplantation
Transplants & implants
Tumor necrosis factor-TNF
title Increased Intestinal Permeability and Stool Zonulin, Calprotectin and Beta-Defensin-2 Concentrations in Allogenic Hematopoietic Cell Transplantation Recipients
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