TRAF3IP2–IL-17 Axis Strengthens the Gingival Defense against Pathogens

Recent genome-wide association studies have suggested novel risk loci associated with periodontitis, which is initiated by dysbiosis in subgingival plaque and leads to destruction of teeth-supporting structures. One such genetic locus was the tumor necrosis factor receptor–associated factor 3 intera...

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Veröffentlicht in:	Journal of dental research 2023-01, Vol.102 (1), p.103-115
Hauptverfasser:	Zhang, J., Sun, L., Withanage, M.H.H., Ganesan, S.M., Williamson, M.A., Marchesan, J.T., Jiao, Y., Teles, F.R., Yu, N., Liu, Y., Wu, D., Moss, K.L., Mangalam, A.K., Zeng, E., Lei, Y.L., Zhang, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor proteins Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Alveolar bone Alveolar Bone Loss - metabolism Animals Bone loss Chemokines Dysbacteriosis Epithelial cells Genome-wide association studies Genome-Wide Association Study Genomes Gingiva Gingiva - metabolism Gum disease Interleukin 17 Interleukin 8 Interleukin-17 - metabolism Leukocytes (neutrophilic) Mice Mice, Knockout Monocyte chemoattractant protein 1 Neutrophils Pathogens Periodontitis Periodontitis - microbiology Porphyromonas gingivalis Research Reports rRNA 16S Sequence analysis Transcriptomics
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