The predictive value of common symptoms in early pregnancy for complications later in pregnancy and at birth
Introduction The aim was to investigate whether common pregnancy‐related symptoms—nausea, vomiting, back pain, pelvic girdle pain, pelvic cavity pain, vaginal bleeding, itching of vulva, pregnancy itching, leg cramps, uterine contractions and varicose veins—in the first trimester of pregnancy add to...
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| Veröffentlicht in: | Acta obstetricia et gynecologica Scandinavica 2023-01, Vol.102 (1), p.33-42 |
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| container_title | Acta obstetricia et gynecologica Scandinavica |
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| creator | Ertmann, Ruth Kirk Nicolaisdottir, Dagny Ros Kragstrup, Jakob Overbeck, Gritt Kriegbaum, Margit Siersma, Volkert |
| description | Introduction
The aim was to investigate whether common pregnancy‐related symptoms—nausea, vomiting, back pain, pelvic girdle pain, pelvic cavity pain, vaginal bleeding, itching of vulva, pregnancy itching, leg cramps, uterine contractions and varicose veins—in the first trimester of pregnancy add to the identification of women at high risk of future pregnancy and birth complications.
Material and methods
Survey data linked to national register data. All women booking an appointment for a first prenatal visit in one of 192 randomly selected General Practices in East Denmark in the period April 2015–August 2016. The General Practices included 1491 women to this prospective study. Two outcomes, pregnancy complications and birth complications, were collected from the Danish Medical Birth Register.
Results
Among the 1413 included women, 199 (14%) experienced complications in later pregnancy. The most serious complication, miscarriage, was experienced by 65 women (4.6%). Other common pregnancy complications were gestational diabetes mellitus (n = 11, 0.8%), gestational hypertension without proteinuria (n = 34, 2.4%), mild to moderate preeclampsia (n = 34, 2.4%) and gestational itching with effect on liver (n = 17, 1.2%). Women who experienced pelvic girdle pain, pelvic cavity pain or vaginal bleeding in the first trimester of pregnancy had a higher risk of pregnancy complications later on in later pregnancy. None of the other examined symptoms showed associations to pregnancy complications. No associations were found between pregnancy‐related physical symptoms in first trimester and birth complications.
Conclusions
Symptoms in early pregnancy do not add much information about the risk of pregnancy or birth complications, although pain and bleeding may give reason for some concern. This is an important message to women experiencing these common symptoms and to their caregivers.
Women who experienced pelvic girdle pain, pelvic cavity pain or vaginal bleeding in the first trimester of pregnancy had a higher risk of later pregnancy complications, but we found no significant associations between any early pregnancy symptoms and birth complications. |
| doi_str_mv | 10.1111/aogs.14474 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9780714</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2729515447</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3784-3d1eaeaa38d512618e98072d5313a859e593444abe1592ac66366d558a5e99c23</originalsourceid><addsrcrecordid>eNp90U1rFDEYB_BBFLtWL34ACXiRwtRk8jKTi1CKrUKhB-s5PJt5djclk6zJzMp8ezNurS8HcwkhP_55-VfVa0bPWRnvIW7zOROiFU-qFVOU1lSw5mm1opSyWnGhT6oXOd-XVdOK7nl1whWntOvUqvJ3OyT7hL2zozsgOYCfkMQNsXEYYiB5HvZjHDJxgSAkPy94GyDYmWxiWtjeOwujiyETDyOmhf5GEHoCI1m7NO5eVs824DO-ephPq69XH-8uP9U3t9efLy9uasvbTtS8ZwgIwLteskaxDnVH26aXnHHopEapuRAC1sikbsAqxZXqpexAota24afVh2PufloP2FsMYwJv9skNkGYTwZm_d4LbmW08GN2Wg5goAe8eAlL8NmEezeCyRe8hYJyyadpGSybLlxf69h96H6cUyvOKkkozKjgv6uyobIo5J9w8XoZRs5RolhLNzxILfvPn9R_pr9YKYEfw3Xmc_xNlLm6vvxxDfwBsWKh-</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2756910433</pqid></control><display><type>article</type><title>The predictive value of common symptoms in early pregnancy for complications later in pregnancy and at birth</title><source>MEDLINE</source><source>Wiley Online Library Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library All Journals</source><source>PubMed Central</source><creator>Ertmann, Ruth Kirk ; Nicolaisdottir, Dagny Ros ; Kragstrup, Jakob ; Overbeck, Gritt ; Kriegbaum, Margit ; Siersma, Volkert</creator><creatorcontrib>Ertmann, Ruth Kirk ; Nicolaisdottir, Dagny Ros ; Kragstrup, Jakob ; Overbeck, Gritt ; Kriegbaum, Margit ; Siersma, Volkert</creatorcontrib><description>Introduction
The aim was to investigate whether common pregnancy‐related symptoms—nausea, vomiting, back pain, pelvic girdle pain, pelvic cavity pain, vaginal bleeding, itching of vulva, pregnancy itching, leg cramps, uterine contractions and varicose veins—in the first trimester of pregnancy add to the identification of women at high risk of future pregnancy and birth complications.
Material and methods
Survey data linked to national register data. All women booking an appointment for a first prenatal visit in one of 192 randomly selected General Practices in East Denmark in the period April 2015–August 2016. The General Practices included 1491 women to this prospective study. Two outcomes, pregnancy complications and birth complications, were collected from the Danish Medical Birth Register.
Results
Among the 1413 included women, 199 (14%) experienced complications in later pregnancy. The most serious complication, miscarriage, was experienced by 65 women (4.6%). Other common pregnancy complications were gestational diabetes mellitus (n = 11, 0.8%), gestational hypertension without proteinuria (n = 34, 2.4%), mild to moderate preeclampsia (n = 34, 2.4%) and gestational itching with effect on liver (n = 17, 1.2%). Women who experienced pelvic girdle pain, pelvic cavity pain or vaginal bleeding in the first trimester of pregnancy had a higher risk of pregnancy complications later on in later pregnancy. None of the other examined symptoms showed associations to pregnancy complications. No associations were found between pregnancy‐related physical symptoms in first trimester and birth complications.
Conclusions
Symptoms in early pregnancy do not add much information about the risk of pregnancy or birth complications, although pain and bleeding may give reason for some concern. This is an important message to women experiencing these common symptoms and to their caregivers.
Women who experienced pelvic girdle pain, pelvic cavity pain or vaginal bleeding in the first trimester of pregnancy had a higher risk of later pregnancy complications, but we found no significant associations between any early pregnancy symptoms and birth complications.</description><identifier>ISSN: 0001-6349</identifier><identifier>EISSN: 1600-0412</identifier><identifier>DOI: 10.1111/aogs.14474</identifier><identifier>PMID: 36300886</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>birth complications ; Childbirth & labor ; cohort ; Female ; first trimester ; general practice ; Gestational diabetes ; Health risks ; Hemorrhage ; Humans ; Hypertension ; Infant, Newborn ; Miscarriage ; Original ; Pain ; Parturition ; pelvic cavity pain ; Pelvic Girdle Pain ; Pelvic Pain ; Preeclampsia ; Pregnancy ; Pregnancy complications ; Pregnancy Complications - diagnosis ; Pregnancy Complications - epidemiology ; Pregnancy Trimester, First ; Prospective Studies ; Uterine Hemorrhage - epidemiology ; Uterine Hemorrhage - etiology ; Vagina ; vaginal bleeding</subject><ispartof>Acta obstetricia et gynecologica Scandinavica, 2023-01, Vol.102 (1), p.33-42</ispartof><rights>2022 The Authors. published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG).</rights><rights>2022 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG).</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3784-3d1eaeaa38d512618e98072d5313a859e593444abe1592ac66366d558a5e99c23</citedby><cites>FETCH-LOGICAL-c3784-3d1eaeaa38d512618e98072d5313a859e593444abe1592ac66366d558a5e99c23</cites><orcidid>0000-0003-4629-3518</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780714/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780714/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36300886$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ertmann, Ruth Kirk</creatorcontrib><creatorcontrib>Nicolaisdottir, Dagny Ros</creatorcontrib><creatorcontrib>Kragstrup, Jakob</creatorcontrib><creatorcontrib>Overbeck, Gritt</creatorcontrib><creatorcontrib>Kriegbaum, Margit</creatorcontrib><creatorcontrib>Siersma, Volkert</creatorcontrib><title>The predictive value of common symptoms in early pregnancy for complications later in pregnancy and at birth</title><title>Acta obstetricia et gynecologica Scandinavica</title><addtitle>Acta Obstet Gynecol Scand</addtitle><description>Introduction
The aim was to investigate whether common pregnancy‐related symptoms—nausea, vomiting, back pain, pelvic girdle pain, pelvic cavity pain, vaginal bleeding, itching of vulva, pregnancy itching, leg cramps, uterine contractions and varicose veins—in the first trimester of pregnancy add to the identification of women at high risk of future pregnancy and birth complications.
Material and methods
Survey data linked to national register data. All women booking an appointment for a first prenatal visit in one of 192 randomly selected General Practices in East Denmark in the period April 2015–August 2016. The General Practices included 1491 women to this prospective study. Two outcomes, pregnancy complications and birth complications, were collected from the Danish Medical Birth Register.
Results
Among the 1413 included women, 199 (14%) experienced complications in later pregnancy. The most serious complication, miscarriage, was experienced by 65 women (4.6%). Other common pregnancy complications were gestational diabetes mellitus (n = 11, 0.8%), gestational hypertension without proteinuria (n = 34, 2.4%), mild to moderate preeclampsia (n = 34, 2.4%) and gestational itching with effect on liver (n = 17, 1.2%). Women who experienced pelvic girdle pain, pelvic cavity pain or vaginal bleeding in the first trimester of pregnancy had a higher risk of pregnancy complications later on in later pregnancy. None of the other examined symptoms showed associations to pregnancy complications. No associations were found between pregnancy‐related physical symptoms in first trimester and birth complications.
Conclusions
Symptoms in early pregnancy do not add much information about the risk of pregnancy or birth complications, although pain and bleeding may give reason for some concern. This is an important message to women experiencing these common symptoms and to their caregivers.
Women who experienced pelvic girdle pain, pelvic cavity pain or vaginal bleeding in the first trimester of pregnancy had a higher risk of later pregnancy complications, but we found no significant associations between any early pregnancy symptoms and birth complications.</description><subject>birth complications</subject><subject>Childbirth & labor</subject><subject>cohort</subject><subject>Female</subject><subject>first trimester</subject><subject>general practice</subject><subject>Gestational diabetes</subject><subject>Health risks</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Infant, Newborn</subject><subject>Miscarriage</subject><subject>Original</subject><subject>Pain</subject><subject>Parturition</subject><subject>pelvic cavity pain</subject><subject>Pelvic Girdle Pain</subject><subject>Pelvic Pain</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Pregnancy Complications - diagnosis</subject><subject>Pregnancy Complications - epidemiology</subject><subject>Pregnancy Trimester, First</subject><subject>Prospective Studies</subject><subject>Uterine Hemorrhage - epidemiology</subject><subject>Uterine Hemorrhage - etiology</subject><subject>Vagina</subject><subject>vaginal bleeding</subject><issn>0001-6349</issn><issn>1600-0412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp90U1rFDEYB_BBFLtWL34ACXiRwtRk8jKTi1CKrUKhB-s5PJt5djclk6zJzMp8ezNurS8HcwkhP_55-VfVa0bPWRnvIW7zOROiFU-qFVOU1lSw5mm1opSyWnGhT6oXOd-XVdOK7nl1whWntOvUqvJ3OyT7hL2zozsgOYCfkMQNsXEYYiB5HvZjHDJxgSAkPy94GyDYmWxiWtjeOwujiyETDyOmhf5GEHoCI1m7NO5eVs824DO-ephPq69XH-8uP9U3t9efLy9uasvbTtS8ZwgIwLteskaxDnVH26aXnHHopEapuRAC1sikbsAqxZXqpexAota24afVh2PufloP2FsMYwJv9skNkGYTwZm_d4LbmW08GN2Wg5goAe8eAlL8NmEezeCyRe8hYJyyadpGSybLlxf69h96H6cUyvOKkkozKjgv6uyobIo5J9w8XoZRs5RolhLNzxILfvPn9R_pr9YKYEfw3Xmc_xNlLm6vvxxDfwBsWKh-</recordid><startdate>202301</startdate><enddate>202301</enddate><creator>Ertmann, Ruth Kirk</creator><creator>Nicolaisdottir, Dagny Ros</creator><creator>Kragstrup, Jakob</creator><creator>Overbeck, Gritt</creator><creator>Kriegbaum, Margit</creator><creator>Siersma, Volkert</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4629-3518</orcidid></search><sort><creationdate>202301</creationdate><title>The predictive value of common symptoms in early pregnancy for complications later in pregnancy and at birth</title><author>Ertmann, Ruth Kirk ; Nicolaisdottir, Dagny Ros ; Kragstrup, Jakob ; Overbeck, Gritt ; Kriegbaum, Margit ; Siersma, Volkert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3784-3d1eaeaa38d512618e98072d5313a859e593444abe1592ac66366d558a5e99c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>birth complications</topic><topic>Childbirth & labor</topic><topic>cohort</topic><topic>Female</topic><topic>first trimester</topic><topic>general practice</topic><topic>Gestational diabetes</topic><topic>Health risks</topic><topic>Hemorrhage</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Infant, Newborn</topic><topic>Miscarriage</topic><topic>Original</topic><topic>Pain</topic><topic>Parturition</topic><topic>pelvic cavity pain</topic><topic>Pelvic Girdle Pain</topic><topic>Pelvic Pain</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>Pregnancy Complications - diagnosis</topic><topic>Pregnancy Complications - epidemiology</topic><topic>Pregnancy Trimester, First</topic><topic>Prospective Studies</topic><topic>Uterine Hemorrhage - epidemiology</topic><topic>Uterine Hemorrhage - etiology</topic><topic>Vagina</topic><topic>vaginal bleeding</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ertmann, Ruth Kirk</creatorcontrib><creatorcontrib>Nicolaisdottir, Dagny Ros</creatorcontrib><creatorcontrib>Kragstrup, Jakob</creatorcontrib><creatorcontrib>Overbeck, Gritt</creatorcontrib><creatorcontrib>Kriegbaum, Margit</creatorcontrib><creatorcontrib>Siersma, Volkert</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ertmann, Ruth Kirk</au><au>Nicolaisdottir, Dagny Ros</au><au>Kragstrup, Jakob</au><au>Overbeck, Gritt</au><au>Kriegbaum, Margit</au><au>Siersma, Volkert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The predictive value of common symptoms in early pregnancy for complications later in pregnancy and at birth</atitle><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle><addtitle>Acta Obstet Gynecol Scand</addtitle><date>2023-01</date><risdate>2023</risdate><volume>102</volume><issue>1</issue><spage>33</spage><epage>42</epage><pages>33-42</pages><issn>0001-6349</issn><eissn>1600-0412</eissn><abstract>Introduction
The aim was to investigate whether common pregnancy‐related symptoms—nausea, vomiting, back pain, pelvic girdle pain, pelvic cavity pain, vaginal bleeding, itching of vulva, pregnancy itching, leg cramps, uterine contractions and varicose veins—in the first trimester of pregnancy add to the identification of women at high risk of future pregnancy and birth complications.
Material and methods
Survey data linked to national register data. All women booking an appointment for a first prenatal visit in one of 192 randomly selected General Practices in East Denmark in the period April 2015–August 2016. The General Practices included 1491 women to this prospective study. Two outcomes, pregnancy complications and birth complications, were collected from the Danish Medical Birth Register.
Results
Among the 1413 included women, 199 (14%) experienced complications in later pregnancy. The most serious complication, miscarriage, was experienced by 65 women (4.6%). Other common pregnancy complications were gestational diabetes mellitus (n = 11, 0.8%), gestational hypertension without proteinuria (n = 34, 2.4%), mild to moderate preeclampsia (n = 34, 2.4%) and gestational itching with effect on liver (n = 17, 1.2%). Women who experienced pelvic girdle pain, pelvic cavity pain or vaginal bleeding in the first trimester of pregnancy had a higher risk of pregnancy complications later on in later pregnancy. None of the other examined symptoms showed associations to pregnancy complications. No associations were found between pregnancy‐related physical symptoms in first trimester and birth complications.
Conclusions
Symptoms in early pregnancy do not add much information about the risk of pregnancy or birth complications, although pain and bleeding may give reason for some concern. This is an important message to women experiencing these common symptoms and to their caregivers.
Women who experienced pelvic girdle pain, pelvic cavity pain or vaginal bleeding in the first trimester of pregnancy had a higher risk of later pregnancy complications, but we found no significant associations between any early pregnancy symptoms and birth complications.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>36300886</pmid><doi>10.1111/aogs.14474</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-4629-3518</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; PubMed Central |
| subjects | birth complications Childbirth & labor cohort Female first trimester general practice Gestational diabetes Health risks Hemorrhage Humans Hypertension Infant, Newborn Miscarriage Original Pain Parturition pelvic cavity pain Pelvic Girdle Pain Pelvic Pain Preeclampsia Pregnancy Pregnancy complications Pregnancy Complications - diagnosis Pregnancy Complications - epidemiology Pregnancy Trimester, First Prospective Studies Uterine Hemorrhage - epidemiology Uterine Hemorrhage - etiology Vagina vaginal bleeding |
| title | The predictive value of common symptoms in early pregnancy for complications later in pregnancy and at birth |
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