Expanding the Therapeutic Window of EGFR-Targeted PE24 Immunotoxin for EGFR-Overexpressing Cancers by Tailoring the EGFR Binding Affinity

Immunotoxins (ITs), which are toxin-fused tumor antigen-specific antibody chimeric proteins, have been developed to selectively kill targeted cancer cells. The epidermal growth factor receptor (EGFR) is an attractive target for the development of anti-EGFR ITs against solid tumors due to its overexp...

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Veröffentlicht in:	International journal of molecular sciences 2022-12, Vol.23 (24), p.15820
Hauptverfasser:	Jun, Sei-Yong, Kim, Dae-Seong, Kim, Yong-Sung
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Animal models Animals Antibodies Antigen (tumor-associated) Antigens Antigens, Neoplasm Antineoplastic Agents Binding Cancer Cell Line, Tumor Cell surface Cross-reactivity Cytotoxicity Epidermal growth factor Epidermal growth factor receptors ErbB Receptors - metabolism Exotoxin A Exotoxins Growth factors Humans Immunotoxins Immunotoxins - pharmacology Immunotoxins - therapeutic use Interferometry Intravenous administration Kinases Ligands Mice Mutation Neoplasms - drug therapy Proteins Retention Solid tumors Toxicity Tumor cell lines Tumors Xenografts Xenotransplantation
Online-Zugang:	Volltext
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