microRNAs Associated with Carotid Plaque Development and Vulnerability: The Clinician's Perspective
Ischemic stroke (IS) related to atherosclerosis of large arteries is one of the leading causes of mortality and disability in developed countries. Atherosclerotic internal carotid artery stenosis (ICAS) contributes to 20% of all cerebral ischemia cases. Nowadays, atherosclerosis prevention and treat...
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| Veröffentlicht in: | International journal of molecular sciences 2022-12, Vol.23 (24), p.15645 |
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| creator | Badacz, Rafał Przewłocki, Tadeusz Legutko, Jacek Żmudka, Krzysztof Kabłak-Ziembicka, Anna |
| description | Ischemic stroke (IS) related to atherosclerosis of large arteries is one of the leading causes of mortality and disability in developed countries. Atherosclerotic internal carotid artery stenosis (ICAS) contributes to 20% of all cerebral ischemia cases. Nowadays, atherosclerosis prevention and treatment measures aim at controlling the atherosclerosis risk factors, or at the interventional (surgical or endovascular) management of mature occlusive lesions. There is a definite lack of the established circulating biomarkers which, once modulated, could prevent development of atherosclerosis, and consequently prevent the carotid-artery-related IS. Recent studies emphasize that microRNA (miRNA) are the emerging particles that could potentially play a pivotal role in this approach. There are some research studies on the association between the expression of small non-coding microRNAs with a carotid plaque development and vulnerability. However, the data remain inconsistent. In addition, all major studies on carotid atherosclerotic plaque were conducted on cell culture or animal models; very few were conducted on humans, whereas the accumulating evidence demonstrates that it cannot be automatically extrapolated to processes in humans. Therefore, this paper aims to review the current knowledge on how miRNA participate in the process of carotid plaque formation and rupture, as well as stroke occurrence. We discuss potential target miRNA that could be used as a prognostic or therapeutic tool. |
| doi_str_mv | 10.3390/ijms232415645 |
| format | Article |
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Atherosclerotic internal carotid artery stenosis (ICAS) contributes to 20% of all cerebral ischemia cases. Nowadays, atherosclerosis prevention and treatment measures aim at controlling the atherosclerosis risk factors, or at the interventional (surgical or endovascular) management of mature occlusive lesions. There is a definite lack of the established circulating biomarkers which, once modulated, could prevent development of atherosclerosis, and consequently prevent the carotid-artery-related IS. Recent studies emphasize that microRNA (miRNA) are the emerging particles that could potentially play a pivotal role in this approach. There are some research studies on the association between the expression of small non-coding microRNAs with a carotid plaque development and vulnerability. However, the data remain inconsistent. In addition, all major studies on carotid atherosclerotic plaque were conducted on cell culture or animal models; very few were conducted on humans, whereas the accumulating evidence demonstrates that it cannot be automatically extrapolated to processes in humans. Therefore, this paper aims to review the current knowledge on how miRNA participate in the process of carotid plaque formation and rupture, as well as stroke occurrence. We discuss potential target miRNA that could be used as a prognostic or therapeutic tool.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms232415645</identifier><identifier>PMID: 36555285</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animal models ; Animals ; Arteriosclerosis ; Atherosclerosis ; Atherosclerosis - metabolism ; Biomarkers ; Cardiovascular system ; Carotid arteries ; Carotid Arteries - metabolism ; Carotid Artery Diseases - genetics ; Carotid Artery Diseases - pathology ; Carotid Stenosis - metabolism ; Cell culture ; Cholesterol ; Cytokines ; Endothelium ; Gene expression ; Humans ; Inflammation ; Ischemia ; Ischemic Stroke - pathology ; Kinases ; Lipids ; Metabolism ; MicroRNAs ; MicroRNAs - genetics ; miRNA ; Morphology ; Mortality ; Nanoparticles ; Plaque, Atherosclerotic - metabolism ; Review ; Risk analysis ; Risk Factors ; Risk management ; Senescence ; Stenosis ; Stroke ; Tomography ; Vascular endothelial growth factor ; Veins & arteries</subject><ispartof>International journal of molecular sciences, 2022-12, Vol.23 (24), p.15645</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Atherosclerotic internal carotid artery stenosis (ICAS) contributes to 20% of all cerebral ischemia cases. Nowadays, atherosclerosis prevention and treatment measures aim at controlling the atherosclerosis risk factors, or at the interventional (surgical or endovascular) management of mature occlusive lesions. There is a definite lack of the established circulating biomarkers which, once modulated, could prevent development of atherosclerosis, and consequently prevent the carotid-artery-related IS. Recent studies emphasize that microRNA (miRNA) are the emerging particles that could potentially play a pivotal role in this approach. There are some research studies on the association between the expression of small non-coding microRNAs with a carotid plaque development and vulnerability. However, the data remain inconsistent. In addition, all major studies on carotid atherosclerotic plaque were conducted on cell culture or animal models; very few were conducted on humans, whereas the accumulating evidence demonstrates that it cannot be automatically extrapolated to processes in humans. Therefore, this paper aims to review the current knowledge on how miRNA participate in the process of carotid plaque formation and rupture, as well as stroke occurrence. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Badacz, Rafał</au><au>Przewłocki, Tadeusz</au><au>Legutko, Jacek</au><au>Żmudka, Krzysztof</au><au>Kabłak-Ziembicka, Anna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>microRNAs Associated with Carotid Plaque Development and Vulnerability: The Clinician's Perspective</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2022-12-09</date><risdate>2022</risdate><volume>23</volume><issue>24</issue><spage>15645</spage><pages>15645-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Ischemic stroke (IS) related to atherosclerosis of large arteries is one of the leading causes of mortality and disability in developed countries. Atherosclerotic internal carotid artery stenosis (ICAS) contributes to 20% of all cerebral ischemia cases. Nowadays, atherosclerosis prevention and treatment measures aim at controlling the atherosclerosis risk factors, or at the interventional (surgical or endovascular) management of mature occlusive lesions. There is a definite lack of the established circulating biomarkers which, once modulated, could prevent development of atherosclerosis, and consequently prevent the carotid-artery-related IS. Recent studies emphasize that microRNA (miRNA) are the emerging particles that could potentially play a pivotal role in this approach. There are some research studies on the association between the expression of small non-coding microRNAs with a carotid plaque development and vulnerability. However, the data remain inconsistent. In addition, all major studies on carotid atherosclerotic plaque were conducted on cell culture or animal models; very few were conducted on humans, whereas the accumulating evidence demonstrates that it cannot be automatically extrapolated to processes in humans. Therefore, this paper aims to review the current knowledge on how miRNA participate in the process of carotid plaque formation and rupture, as well as stroke occurrence. We discuss potential target miRNA that could be used as a prognostic or therapeutic tool.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36555285</pmid><doi>10.3390/ijms232415645</doi><orcidid>https://orcid.org/0000-0003-0122-1318</orcidid><orcidid>https://orcid.org/0000-0002-8006-7840</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animal models Animals Arteriosclerosis Atherosclerosis Atherosclerosis - metabolism Biomarkers Cardiovascular system Carotid arteries Carotid Arteries - metabolism Carotid Artery Diseases - genetics Carotid Artery Diseases - pathology Carotid Stenosis - metabolism Cell culture Cholesterol Cytokines Endothelium Gene expression Humans Inflammation Ischemia Ischemic Stroke - pathology Kinases Lipids Metabolism MicroRNAs MicroRNAs - genetics miRNA Morphology Mortality Nanoparticles Plaque, Atherosclerotic - metabolism Review Risk analysis Risk Factors Risk management Senescence Stenosis Stroke Tomography Vascular endothelial growth factor Veins & arteries |
| title | microRNAs Associated with Carotid Plaque Development and Vulnerability: The Clinician's Perspective |
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