Exploring Highly Conserved Regions of SARS-CoV-2 Spike S2 Subunit as Targets for Fusion Inhibition Using Chimeric Proteins

Since the beginning of the COVID-19 pandemic, considerable efforts have been made to develop protective vaccines against SARS-CoV-2 infection. However, immunity tends to decline within a few months, and new virus variants are emerging with increased transmissibility and capacity to evade natural or...

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Veröffentlicht in:	International journal of molecular sciences 2022-12, Vol.23 (24), p.15511
Hauptverfasser:	Polo-Megías, Daniel, Cano-Muñoz, Mario, Berruezo, Alberto G, Laumond, Géraldine, Moog, Christiane, Conejero-Lara, Francisco
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Amino Acid Sequence Amino acids Conformation Coronaviruses COVID-19 COVID-19 Vaccines Design Heterogeneity Humans Infections Membrane fusion Membrane Glycoproteins - metabolism Pandemics Peptides Polypeptides Proteins Recombinant Fusion Proteins SARS-CoV-2 - metabolism Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - metabolism Vaccines Viral Envelope Proteins - chemistry Virus attachment Viruses
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