Mechanisms of EGFR-TKI-Induced Apoptosis and Strategies Targeting Apoptosis in EGFR-Mutated Non-Small Cell Lung Cancer

Homeostasis is achieved by balancing cell survival and death. In cancer cells, especially those carrying driver mutations, the processes and signals that promote apoptosis are inhibited, facilitating the survival and proliferation of these dysregulated cells. Apoptosis induction is an important mech...

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Veröffentlicht in:	Genes 2022-11, Vol.13 (12), p.2183
Hauptverfasser:	Nishihara, Shigetoshi, Yamaoka, Toshimitsu, Ishikawa, Fumihiro, Higuchi, Kensuke, Hasebe, Yuki, Manabe, Ryo, Kishino, Yasunari, Kusumoto, Sojiro, Ando, Koichi, Kuroda, Yusuke, Ohmori, Tohru, Sagara, Hironori, Yoshida, Hitoshi, Tsurutani, Junji
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Apoptosis Cancer therapies Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Care and treatment Cell death Cell proliferation Cell survival Chemotherapy Clinical trials Cytochrome Epidermal growth factor Epidermal growth factor receptors ErbB Receptors - genetics ErbB Receptors - metabolism Homeostasis Humans Kinases Lung cancer Lung cancer, Non-small cell Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism Mutation Non-small cell lung carcinoma Precision medicine Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Protein-tyrosine kinase Proteins Response rates Review Small cell lung carcinoma Vascular endothelial growth factor
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