Activation of γ-globin expression by hypoxia-inducible factor 1α

Around birth, globin expression in human red blood cells (RBCs) shifts from γ-globin to β-globin, which results in fetal haemoglobin (HbF, α 2 γ 2 ) being gradually replaced by adult haemoglobin (HbA, α 2 β 2 ) 1 . This process has motivated the development of innovative approaches to treat sickle c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 2022-10, Vol.610 (7933), p.783-790
Hauptverfasser:	Feng, Ruopeng, Mayuranathan, Thiyagaraj, Huang, Peng, Doerfler, Phillip A., Li, Yichao, Yao, Yu, Zhang, Jingjing, Palmer, Lance E., Mayberry, Kalin, Christakopoulos, Georgios E., Xu, Peng, Li, Chunliang, Cheng, Yong, Blobel, Gerd A., Simon, M. Celeste, Weiss, Mitchell J.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/109 13/2 13/31 38/15 38/22 38/23 38/39 38/47 42 42/44 631/208/199 631/80/86/2366 82/58 Adaptation Blood diseases Chromatin Depletion Enzymes Erythrocytes Erythropoiesis Fetal Hemoglobin - biosynthesis Fetal Hemoglobin - genetics Fetuses gamma-Globins - biosynthesis gamma-Globins - genetics Gene expression Gene regulation Genes Hemoglobin Humanities and Social Sciences Humans Hydroxylase Hypoxia Hypoxia - genetics Hypoxia-inducible factor 1a Hypoxia-inducible factors multidisciplinary Prolyl hydroxylase Prolyl Hydroxylases - metabolism Proteasome Endopeptidase Complex - metabolism Proteins Proteomics RNA, Long Noncoding Science Science (multidisciplinary) Sickle cell disease Thalassemia Transcription factors Ubiquitin Ubiquitin - metabolism Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitination VHL protein Yttrium
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!