Inhibition and Mechanism of Plasmodium falciparum Hypoxanthine–Guanine–Xanthine Phosphoribosyltransferase

Plasmodium falciparum hypoxanthine–guanine–xanthine phosphoribosyltransferase (PfHGXPRT) is essential for purine salvage of hypoxanthine into parasite purine nucleotides. Transition state analogue inhibitors of PfHGXPRT are characterized by kinetic analysis, thermodynamic parameters, and X-ray cryst...

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Veröffentlicht in:	ACS chemical biology 2022-12, Vol.17 (12), p.3407-3419
Hauptverfasser:	V. T. Minnow, Yacoba, Suthagar, Kajitha, Clinch, Keith, Ducati, Rodrigo G., Ghosh, Agnidipta, Buckler, Joshua N., Harijan, Rajesh K., Cahill, Sean M., Tyler, Peter C., Schramm, Vern L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry & Molecular Biology Diphosphates Hypoxanthines Isotopes Kinetics Oxygen Plasmodium falciparum
Online-Zugang:	Volltext
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