Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation

The nuclear corepressors NCOR1 and NCOR2 interact with transcription factors involved in B cell development and potentially link these factors to alterations in chromatin structure and gene expression. Herein, we demonstrate that Ncor1/2 deletion limits B cell differentiation via impaired recombinat...

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Veröffentlicht in:	Nature immunology 2022-12, Vol.23 (12), p.1763-1776
Hauptverfasser:	Lee, Robin D., Knutson, Todd P., Munro, Sarah A., Miller, Jeffrey T., Heltemes-Harris, Lynn M., Mullighan, Charles G., Jepsen, Kristen, Farrar, Michael A.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/232/2058 631/250/2502/2170 Animals Biomedical and Life Sciences Biomedicine Cell differentiation Cell Nucleus Chromatin Clonal deletion Co-Repressor Proteins Derepression Gene deletion Gene expression Genetic transformation Genomics Hematopoiesis Humans Immunology Infectious Diseases Leukemia Lymphocytes B Mice Mutation Nuclear Receptor Co-Repressor 1 - genetics Nuclear Receptor Co-Repressor 2 - genetics p53 Protein RAG gene RAG1 protein RAG2 protein Recombination Signal Transduction Stat5 protein Transcription factors Whole genome sequencing
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