Brain age estimation reveals older adults’ accelerated senescence after traumatic brain injury
Adults aged 60 and over are most vulnerable to mild traumatic brain injury (mTBI). Nevertheless, the extent to which chronological age (CA) at injury affects TBI-related brain aging is unknown. This study applies Gaussian process regression to T 1 -weighted magnetic resonance images (MRIs) acquired...
Gespeichert in:
| Veröffentlicht in: | GeroScience 2022-10, Vol.44 (5), p.2509-2525 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2525 |
|---|---|
| container_issue | 5 |
| container_start_page | 2509 |
| container_title | GeroScience |
| container_volume | 44 |
| creator | Amgalan, Anar Maher, Alexander S. Ghosh, Satyaki Chui, Helena C. Bogdan, Paul Irimia, Andrei |
| description | Adults aged 60 and over are most vulnerable to mild traumatic brain injury (mTBI). Nevertheless, the extent to which chronological age (CA) at injury affects TBI-related brain aging is unknown. This study applies Gaussian process regression to
T
1
-weighted magnetic resonance images (MRIs) acquired within
∼
7 days and again
∼
6 months after a single mTBI sustained by 133 participants aged 20–83 (CA
μ
±
σ
= 42.6 ± 17 years; 51 females). Brain BAs are estimated, modeled, and compared as a function of sex and CA at injury using a statistical model selection procedure. On average, the brains of older adults age by 15.3 ± 6.9 years after mTBI, whereas those of younger adults age only by 1.8 ± 5.6 years, a significant difference (Welch’s
t
32
= − 9.17,
p
≃ 9.47 × 10
−11
). For an adult aged
∼
30 to
∼
60, the expected amount of TBI-related brain aging is
∼
3 years greater than in an individual younger by a decade. For an individual over
∼
60, the respective amount is
∼
7 years. Despite no significant sex differences in brain aging (Welch’s
t
108
= 0.78,
p
> 0.78), the statistical test is underpowered. BAs estimated at acute baseline versus chronic follow-up do not differ significantly (
t
264
= 0.41,
p
> 0.66, power = 80%), suggesting negligible TBI-related brain aging during the
chronic
stage of TBI despite accelerated aging during the
acute
stage. Our results indicate that a single mTBI sustained after age
∼
60 involves approximately
∼
10 years of premature and lasting brain aging, which is MRI detectable as early as
∼
7 days post-injury. |
| doi_str_mv | 10.1007/s11357-022-00597-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9768106</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2685446032</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-fba7a3864788cb9ec2c3a777bdfbf66ebf0fd6ab15adf18a475dda996ee141c43</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhS0EolXpC7BAltiwCXhsx042SFDxJ1ViA2sztieXVLlOsZNK3fU1eD2eBN_ecvlZsLKlOefzHB_GHoN4DkLYFwVAtbYRUjZCtL1t4B47lq3oG2mlun-4Q3vETksZvdASQFjVPWRH1dnL3sAx-_I645g4bohTWcYtLuOceKYrwqnweYqUOcZ1WsqPm-8cQ6CJMi4UeaFEJVAKxHFYqmzJuO78gftb5pgu1nz9iD0YKopO784T9vntm09n75vzj-8-nL06b4K2emkGjxZVZ7TtuuB7CjIotNb6OPjBGPKDGKJBDy3GATrUto0R-94QgYag1Ql7uedern5LsS5W95ncZa6Z8rWbcXR_T9L41W3mK9db04EwFfDsDpDnb2v9DLcda75pwkTzWpw0Xau1EUpW6dN_pBfzmlON56RtDWirYAeUe1XIcymZhsMyINyuQ7fv0NUO3W2HDqrpyZ8xDpZfjVWB2gtKHaUN5d9v_wf7E4kzq1A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2756147316</pqid></control><display><type>article</type><title>Brain age estimation reveals older adults’ accelerated senescence after traumatic brain injury</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Amgalan, Anar ; Maher, Alexander S. ; Ghosh, Satyaki ; Chui, Helena C. ; Bogdan, Paul ; Irimia, Andrei</creator><creatorcontrib>Amgalan, Anar ; Maher, Alexander S. ; Ghosh, Satyaki ; Chui, Helena C. ; Bogdan, Paul ; Irimia, Andrei</creatorcontrib><description>Adults aged 60 and over are most vulnerable to mild traumatic brain injury (mTBI). Nevertheless, the extent to which chronological age (CA) at injury affects TBI-related brain aging is unknown. This study applies Gaussian process regression to
T
1
-weighted magnetic resonance images (MRIs) acquired within
∼
7 days and again
∼
6 months after a single mTBI sustained by 133 participants aged 20–83 (CA
μ
±
σ
= 42.6 ± 17 years; 51 females). Brain BAs are estimated, modeled, and compared as a function of sex and CA at injury using a statistical model selection procedure. On average, the brains of older adults age by 15.3 ± 6.9 years after mTBI, whereas those of younger adults age only by 1.8 ± 5.6 years, a significant difference (Welch’s
t
32
= − 9.17,
p
≃ 9.47 × 10
−11
). For an adult aged
∼
30 to
∼
60, the expected amount of TBI-related brain aging is
∼
3 years greater than in an individual younger by a decade. For an individual over
∼
60, the respective amount is
∼
7 years. Despite no significant sex differences in brain aging (Welch’s
t
108
= 0.78,
p
> 0.78), the statistical test is underpowered. BAs estimated at acute baseline versus chronic follow-up do not differ significantly (
t
264
= 0.41,
p
> 0.66, power = 80%), suggesting negligible TBI-related brain aging during the
chronic
stage of TBI despite accelerated aging during the
acute
stage. Our results indicate that a single mTBI sustained after age
∼
60 involves approximately
∼
10 years of premature and lasting brain aging, which is MRI detectable as early as
∼
7 days post-injury.</description><identifier>ISSN: 2509-2715</identifier><identifier>EISSN: 2509-2723</identifier><identifier>DOI: 10.1007/s11357-022-00597-1</identifier><identifier>PMID: 35792961</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Age ; Age determination ; Aged ; Aging ; Aging - pathology ; Biomedical and Life Sciences ; Brain - diagnostic imaging ; Brain Injuries, Traumatic ; Cell Biology ; Female ; Geriatrics/Gerontology ; Humans ; Life Sciences ; Magnetic Resonance Imaging ; Male ; Mathematical models ; Middle Aged ; Molecular Medicine ; Older people ; Original ; Original Article ; Senescence ; Sex differences ; Traumatic brain injury</subject><ispartof>GeroScience, 2022-10, Vol.44 (5), p.2509-2525</ispartof><rights>The Author(s), under exclusive licence to American Aging Association 2022</rights><rights>2022. The Author(s), under exclusive licence to American Aging Association.</rights><rights>The Author(s), under exclusive licence to American Aging Association 2022.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-fba7a3864788cb9ec2c3a777bdfbf66ebf0fd6ab15adf18a475dda996ee141c43</citedby><cites>FETCH-LOGICAL-c474t-fba7a3864788cb9ec2c3a777bdfbf66ebf0fd6ab15adf18a475dda996ee141c43</cites><orcidid>0000-0003-4140-6085 ; 0000-0001-8210-5030 ; 0000-0002-9254-9388</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768106/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768106/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35792961$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amgalan, Anar</creatorcontrib><creatorcontrib>Maher, Alexander S.</creatorcontrib><creatorcontrib>Ghosh, Satyaki</creatorcontrib><creatorcontrib>Chui, Helena C.</creatorcontrib><creatorcontrib>Bogdan, Paul</creatorcontrib><creatorcontrib>Irimia, Andrei</creatorcontrib><title>Brain age estimation reveals older adults’ accelerated senescence after traumatic brain injury</title><title>GeroScience</title><addtitle>GeroScience</addtitle><addtitle>Geroscience</addtitle><description>Adults aged 60 and over are most vulnerable to mild traumatic brain injury (mTBI). Nevertheless, the extent to which chronological age (CA) at injury affects TBI-related brain aging is unknown. This study applies Gaussian process regression to
T
1
-weighted magnetic resonance images (MRIs) acquired within
∼
7 days and again
∼
6 months after a single mTBI sustained by 133 participants aged 20–83 (CA
μ
±
σ
= 42.6 ± 17 years; 51 females). Brain BAs are estimated, modeled, and compared as a function of sex and CA at injury using a statistical model selection procedure. On average, the brains of older adults age by 15.3 ± 6.9 years after mTBI, whereas those of younger adults age only by 1.8 ± 5.6 years, a significant difference (Welch’s
t
32
= − 9.17,
p
≃ 9.47 × 10
−11
). For an adult aged
∼
30 to
∼
60, the expected amount of TBI-related brain aging is
∼
3 years greater than in an individual younger by a decade. For an individual over
∼
60, the respective amount is
∼
7 years. Despite no significant sex differences in brain aging (Welch’s
t
108
= 0.78,
p
> 0.78), the statistical test is underpowered. BAs estimated at acute baseline versus chronic follow-up do not differ significantly (
t
264
= 0.41,
p
> 0.66, power = 80%), suggesting negligible TBI-related brain aging during the
chronic
stage of TBI despite accelerated aging during the
acute
stage. Our results indicate that a single mTBI sustained after age
∼
60 involves approximately
∼
10 years of premature and lasting brain aging, which is MRI detectable as early as
∼
7 days post-injury.</description><subject>Age</subject><subject>Age determination</subject><subject>Aged</subject><subject>Aging</subject><subject>Aging - pathology</subject><subject>Biomedical and Life Sciences</subject><subject>Brain - diagnostic imaging</subject><subject>Brain Injuries, Traumatic</subject><subject>Cell Biology</subject><subject>Female</subject><subject>Geriatrics/Gerontology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Mathematical models</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Older people</subject><subject>Original</subject><subject>Original Article</subject><subject>Senescence</subject><subject>Sex differences</subject><subject>Traumatic brain injury</subject><issn>2509-2715</issn><issn>2509-2723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAQhS0EolXpC7BAltiwCXhsx042SFDxJ1ViA2sztieXVLlOsZNK3fU1eD2eBN_ecvlZsLKlOefzHB_GHoN4DkLYFwVAtbYRUjZCtL1t4B47lq3oG2mlun-4Q3vETksZvdASQFjVPWRH1dnL3sAx-_I645g4bohTWcYtLuOceKYrwqnweYqUOcZ1WsqPm-8cQ6CJMi4UeaFEJVAKxHFYqmzJuO78gftb5pgu1nz9iD0YKopO784T9vntm09n75vzj-8-nL06b4K2emkGjxZVZ7TtuuB7CjIotNb6OPjBGPKDGKJBDy3GATrUto0R-94QgYag1Ql7uedern5LsS5W95ncZa6Z8rWbcXR_T9L41W3mK9db04EwFfDsDpDnb2v9DLcda75pwkTzWpw0Xau1EUpW6dN_pBfzmlON56RtDWirYAeUe1XIcymZhsMyINyuQ7fv0NUO3W2HDqrpyZ8xDpZfjVWB2gtKHaUN5d9v_wf7E4kzq1A</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Amgalan, Anar</creator><creator>Maher, Alexander S.</creator><creator>Ghosh, Satyaki</creator><creator>Chui, Helena C.</creator><creator>Bogdan, Paul</creator><creator>Irimia, Andrei</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4140-6085</orcidid><orcidid>https://orcid.org/0000-0001-8210-5030</orcidid><orcidid>https://orcid.org/0000-0002-9254-9388</orcidid></search><sort><creationdate>20221001</creationdate><title>Brain age estimation reveals older adults’ accelerated senescence after traumatic brain injury</title><author>Amgalan, Anar ; Maher, Alexander S. ; Ghosh, Satyaki ; Chui, Helena C. ; Bogdan, Paul ; Irimia, Andrei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-fba7a3864788cb9ec2c3a777bdfbf66ebf0fd6ab15adf18a475dda996ee141c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Age</topic><topic>Age determination</topic><topic>Aged</topic><topic>Aging</topic><topic>Aging - pathology</topic><topic>Biomedical and Life Sciences</topic><topic>Brain - diagnostic imaging</topic><topic>Brain Injuries, Traumatic</topic><topic>Cell Biology</topic><topic>Female</topic><topic>Geriatrics/Gerontology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Mathematical models</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Older people</topic><topic>Original</topic><topic>Original Article</topic><topic>Senescence</topic><topic>Sex differences</topic><topic>Traumatic brain injury</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amgalan, Anar</creatorcontrib><creatorcontrib>Maher, Alexander S.</creatorcontrib><creatorcontrib>Ghosh, Satyaki</creatorcontrib><creatorcontrib>Chui, Helena C.</creatorcontrib><creatorcontrib>Bogdan, Paul</creatorcontrib><creatorcontrib>Irimia, Andrei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>GeroScience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amgalan, Anar</au><au>Maher, Alexander S.</au><au>Ghosh, Satyaki</au><au>Chui, Helena C.</au><au>Bogdan, Paul</au><au>Irimia, Andrei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain age estimation reveals older adults’ accelerated senescence after traumatic brain injury</atitle><jtitle>GeroScience</jtitle><stitle>GeroScience</stitle><addtitle>Geroscience</addtitle><date>2022-10-01</date><risdate>2022</risdate><volume>44</volume><issue>5</issue><spage>2509</spage><epage>2525</epage><pages>2509-2525</pages><issn>2509-2715</issn><eissn>2509-2723</eissn><abstract>Adults aged 60 and over are most vulnerable to mild traumatic brain injury (mTBI). Nevertheless, the extent to which chronological age (CA) at injury affects TBI-related brain aging is unknown. This study applies Gaussian process regression to
T
1
-weighted magnetic resonance images (MRIs) acquired within
∼
7 days and again
∼
6 months after a single mTBI sustained by 133 participants aged 20–83 (CA
μ
±
σ
= 42.6 ± 17 years; 51 females). Brain BAs are estimated, modeled, and compared as a function of sex and CA at injury using a statistical model selection procedure. On average, the brains of older adults age by 15.3 ± 6.9 years after mTBI, whereas those of younger adults age only by 1.8 ± 5.6 years, a significant difference (Welch’s
t
32
= − 9.17,
p
≃ 9.47 × 10
−11
). For an adult aged
∼
30 to
∼
60, the expected amount of TBI-related brain aging is
∼
3 years greater than in an individual younger by a decade. For an individual over
∼
60, the respective amount is
∼
7 years. Despite no significant sex differences in brain aging (Welch’s
t
108
= 0.78,
p
> 0.78), the statistical test is underpowered. BAs estimated at acute baseline versus chronic follow-up do not differ significantly (
t
264
= 0.41,
p
> 0.66, power = 80%), suggesting negligible TBI-related brain aging during the
chronic
stage of TBI despite accelerated aging during the
acute
stage. Our results indicate that a single mTBI sustained after age
∼
60 involves approximately
∼
10 years of premature and lasting brain aging, which is MRI detectable as early as
∼
7 days post-injury.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>35792961</pmid><doi>10.1007/s11357-022-00597-1</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0003-4140-6085</orcidid><orcidid>https://orcid.org/0000-0001-8210-5030</orcidid><orcidid>https://orcid.org/0000-0002-9254-9388</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2509-2715 |
| ispartof | GeroScience, 2022-10, Vol.44 (5), p.2509-2525 |
| issn | 2509-2715 2509-2723 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9768106 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Age Age determination Aged Aging Aging - pathology Biomedical and Life Sciences Brain - diagnostic imaging Brain Injuries, Traumatic Cell Biology Female Geriatrics/Gerontology Humans Life Sciences Magnetic Resonance Imaging Male Mathematical models Middle Aged Molecular Medicine Older people Original Original Article Senescence Sex differences Traumatic brain injury |
| title | Brain age estimation reveals older adults’ accelerated senescence after traumatic brain injury |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T08%3A53%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Brain%20age%20estimation%20reveals%20older%20adults%E2%80%99%20accelerated%20senescence%20after%20traumatic%20brain%20injury&rft.jtitle=GeroScience&rft.au=Amgalan,%20Anar&rft.date=2022-10-01&rft.volume=44&rft.issue=5&rft.spage=2509&rft.epage=2525&rft.pages=2509-2525&rft.issn=2509-2715&rft.eissn=2509-2723&rft_id=info:doi/10.1007/s11357-022-00597-1&rft_dat=%3Cproquest_pubme%3E2685446032%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2756147316&rft_id=info:pmid/35792961&rfr_iscdi=true |