G protein-coupled lactate receptor GPR81 control of ventrolateral ventromedial hypothalamic nucleus glucoregulatory neurotransmitter and 5'-AMP-activated protein kinase expression

Astrocytes store glycogen as energy and promote neurometabolic stability through supply of oxidizable l-lactate. Whether lactate regulates ventromedial hypothalamic nucleus (VMN) glucostatic function as a metabolic volume transmitter is unknown. Current research investigated whether G protein-couple...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2023-01, Vol.324 (1), p.R20-R34
Hauptverfasser:	Roy, Sagor Chandra, Napit, Prabhat R, Pasula, MadhuBabu, Bheemanapally, Khaggeswar, Briski, Karen P
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism Anatomy Animals Astrocytes Astrocytes - metabolism Female Glucose Glucose - metabolism Glutamate decarboxylase Glycogen Glycogen - metabolism Glycogens Hypoglycemia Hypoglycemia - metabolism Hypothalamus Hypothalamus (ventromedial) Information processing Insulin Ionization Kinases Lactic acid Lactic Acid - metabolism Metabolism Neurons Neurotransmission Neurotransmitter Agents - metabolism Neurotransmitters Nitric oxide Nitric-oxide synthase Nuclei (cytology) Proteins Rats Rats, Sprague-Dawley Receptors Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism siRNA Spectrometry Subpopulations Transmitters Ventromedial Hypothalamic Nucleus - metabolism γ-Aminobutyric acid
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