Eosinophils protect against acetaminophen-induced liver injury through cyclooxygenase-mediated IL-4/IL-13 production

A better understanding of the underlying mechanism of acetaminophen (APAP)-induced liver injury (AILI) remains an important endeavor to develop therapeutic approaches. Eosinophils have been detected in liver biopsies of patients with APAP overdose. We recently demonstrated a profound protective role...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2023-02, Vol.77 (2), p.456-465
Hauptverfasser:	Xu, Long, Yang, Yang, Jiang, Jiali, Wen, Yankai, Jeong, Jong-Min, Emontzpohl, Christoph, Atkins, Constance L, Kim, Kangho, Jacobsen, Elizabeth A, Wang, Hua, Ju, Cynthia
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - adverse effects Animals Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury, Chronic - pathology Cyclooxygenase 2 Eosinophils Interleukin-13 - metabolism Interleukin-13 - pharmacology Interleukin-33 - metabolism Interleukin-33 - pharmacology Interleukin-4 - metabolism Interleukin-4 - pharmacology Liver - pathology Mice Mice, Inbred C57BL Mice, Knockout NF-kappa B - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!