CH2- lengthening of the internucleotide linkage in the ApA dimer can improve its conformational compatibility with its natural polynucleotide counterpart

The complete family of ApA phosphonate analogues with the internucleotide linkage elongated by insertion of a -CH2- group was prepared and the hybridisation and structural properties of its members in interaction with polyuridylic acid were investigated using an original 2D Raman approach. Except fo...

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Veröffentlicht in:	Nucleic acids research 2001-12, Vol.29 (24), p.5182-5194
Hauptverfasser:	Hanus, J, Barvík, I, Ruszová-Chmelová, K, Stepánek, J, Turpin, P Y, Bok, J, Rosenberg, I, Petrová-Endová, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Dinucleoside Phosphates - chemistry Hydrogen Bonding Models, Molecular Nucleic Acid Conformation Polynucleotides - chemistry Spectrum Analysis, Raman - methods
Online-Zugang:	Volltext
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