Flavones inhibit the hexameric replicative helicase RepA

Helicases couple the hydrolysis of nucleoside triphosphates (NTPs) to the unwinding of double-stranded nucleic acids and are essential in DNA metabolism. Thus far, no inhibitors are known for helicases except heliquinomycin isolated from Streptomyces sp. As the three-dimensional structure of the hex...

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Veröffentlicht in:	Nucleic acids research 2001-12, Vol.29 (24), p.5058-5066
Hauptverfasser:	Xu, H, Ziegelin, G, Schröder, W, Frank, J, Ayora, S, Alonso, J C, Lanka, E, Saenger, W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - antagonists & inhibitors Adenosine Triphosphatases - metabolism Bacillus subtilis - drug effects Bacillus subtilis - growth & development Cell Division - drug effects dimyricetin DNA Helicases - antagonists & inhibitors DNA Helicases - metabolism DNA-Binding Proteins Dose-Response Relationship, Drug Escherichia coli - drug effects Escherichia coli - growth & development flavones Flavonoids - chemistry Flavonoids - pharmacology Kinetics luteolin morin myricetin Oligonucleotides - genetics Oligonucleotides - metabolism Proteins - antagonists & inhibitors Proteins - metabolism RepA protein Structure-Activity Relationship Trans-Activators
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