Cardiac magnetic resonance imaging of arrhythmogenic cardiomyopathy: evolving diagnostic perspectives
Arrhythmogenic cardiomyopathy (ACM) is a genetically determined heart muscle disease characterized by fibro-fatty myocardial replacement, clinically associated with malignant ventricular arrhythmias and sudden cardiac death. Originally described a disease with a prevalent right ventricular (RV) invo...
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| Veröffentlicht in: | European radiology 2023-01, Vol.33 (1), p.270-282 |
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| creator | Cipriani, Alberto Mattesi, Giulia Bariani, Riccardo Cecere, Annagrazia Martini, Nicolò De Michieli, Laura Da Pozzo, Stefano Corradin, Simone De Conti, Giorgio Zorzi, Alessandro Motta, Raffaella De Lazzari, Manuel Bauce, Barbara Iliceto, Sabino Basso, Cristina Corrado, Domenico Perazzolo Marra, Martina |
| description | Arrhythmogenic cardiomyopathy (ACM) is a genetically determined heart muscle disease characterized by fibro-fatty myocardial replacement, clinically associated with malignant ventricular arrhythmias and sudden cardiac death. Originally described a disease with a prevalent right ventricular (RV) involvement, subsequently two other phenotypes have been recognized, such as the
left dominant
and the
biventricular
phenotypes, for which a recent International Expert consensus document provided upgrade diagnostic criteria (the 2020 “Padua Criteria”). In this novel workup for the diagnosis of the entire spectrum of phenotypic variants of ACM, including left ventricular (LV) variants, cardiac magnetic resonance (CMR) has emerged as the cardiac imaging technique of choice, due to its capability of detailed morpho-functional and tissue characterization evaluation of both RV and LV. In this review, the key role of CMR in the diagnosis of ACM is outlined, including the supplemental value for the characterization of the disease variants. An ACM-specific CMR study protocol, as well as strengths and weaknesses of each imaging technique, is also provided.
Key Points
• Arrhythmogenic cardiomyopathy includes three different phenotypes: dominant right, biventricular, and dominant left.
• In 2020, diagnostic criteria have been updated and cardiac magnetic resonance has emerged as the cardiac imaging technique of choice.
• This aim of this review is to provide an update of the current state of art regarding the use of CMR in ACM, with a particular focus on novel diagnostic criteria, CMR protocols, and prognostic significance of CMR findings in ACM. |
| doi_str_mv | 10.1007/s00330-022-08958-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9755099</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2685033024</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-15161b550a32d468af0129b2b8fc2fc79bbc5f9b9e7191c2d3d64877a4d97c9b3</originalsourceid><addsrcrecordid>eNp9kU9v3CAQxVHVqNmk_QI5VJZ66cUJYDCQQ6Vq1fyRVsolPSOMx16vbHDBu9J---Jsukl6yAnE_ObNPB5CFwRfEozFVcS4KHCOKc2xVFzm9ANaEFbQnGDJPr66n6KzGDcYY0WY-IROCy6kFFwuECxNqDtjs8G0DqbOZgGid8ZZyLr01rk2801mQljvp_XgW3CJsXOTH_Z-NNN6f53Bzve7GU1SrfNx1hkhxBHs1O0gfkYnjekjfHk-z9Hvm1-Py7t89XB7v_y5yi0TbMoJJyWpOMemoDUrpWkwoaqilWwsbaxQVWV5oyoFgihiaV3UJZNCGFYrYVVVnKMfB91xWw1QW3BTML0eQ7IS9tqbTr-tuG6tW7_TSqSpSiWB788Cwf_ZQpz00EULfW8c-G3UtJR8_nTKEvrtP3Tjt8Ele5oKzkqmJMOJogfKBh9jgOa4DMF6TlEfUtQpRf2Uoqap6etrG8eWf7EloDgAMZVcC-Fl9juyfwGit6rr</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2754649840</pqid></control><display><type>article</type><title>Cardiac magnetic resonance imaging of arrhythmogenic cardiomyopathy: evolving diagnostic perspectives</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Cipriani, Alberto ; Mattesi, Giulia ; Bariani, Riccardo ; Cecere, Annagrazia ; Martini, Nicolò ; De Michieli, Laura ; Da Pozzo, Stefano ; Corradin, Simone ; De Conti, Giorgio ; Zorzi, Alessandro ; Motta, Raffaella ; De Lazzari, Manuel ; Bauce, Barbara ; Iliceto, Sabino ; Basso, Cristina ; Corrado, Domenico ; Perazzolo Marra, Martina</creator><creatorcontrib>Cipriani, Alberto ; Mattesi, Giulia ; Bariani, Riccardo ; Cecere, Annagrazia ; Martini, Nicolò ; De Michieli, Laura ; Da Pozzo, Stefano ; Corradin, Simone ; De Conti, Giorgio ; Zorzi, Alessandro ; Motta, Raffaella ; De Lazzari, Manuel ; Bauce, Barbara ; Iliceto, Sabino ; Basso, Cristina ; Corrado, Domenico ; Perazzolo Marra, Martina</creatorcontrib><description>Arrhythmogenic cardiomyopathy (ACM) is a genetically determined heart muscle disease characterized by fibro-fatty myocardial replacement, clinically associated with malignant ventricular arrhythmias and sudden cardiac death. Originally described a disease with a prevalent right ventricular (RV) involvement, subsequently two other phenotypes have been recognized, such as the
left dominant
and the
biventricular
phenotypes, for which a recent International Expert consensus document provided upgrade diagnostic criteria (the 2020 “Padua Criteria”). In this novel workup for the diagnosis of the entire spectrum of phenotypic variants of ACM, including left ventricular (LV) variants, cardiac magnetic resonance (CMR) has emerged as the cardiac imaging technique of choice, due to its capability of detailed morpho-functional and tissue characterization evaluation of both RV and LV. In this review, the key role of CMR in the diagnosis of ACM is outlined, including the supplemental value for the characterization of the disease variants. An ACM-specific CMR study protocol, as well as strengths and weaknesses of each imaging technique, is also provided.
Key Points
• Arrhythmogenic cardiomyopathy includes three different phenotypes: dominant right, biventricular, and dominant left.
• In 2020, diagnostic criteria have been updated and cardiac magnetic resonance has emerged as the cardiac imaging technique of choice.
• This aim of this review is to provide an update of the current state of art regarding the use of CMR in ACM, with a particular focus on novel diagnostic criteria, CMR protocols, and prognostic significance of CMR findings in ACM.</description><identifier>ISSN: 1432-1084</identifier><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-022-08958-2</identifier><identifier>PMID: 35788758</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Arrhythmogenic Right Ventricular Dysplasia - diagnostic imaging ; Arrhythmogenic Right Ventricular Dysplasia - genetics ; Cardiac ; Cardiac muscle ; Cardiomyopathy ; Criteria ; Death, Sudden, Cardiac - pathology ; Diagnosis ; Diagnostic Radiology ; Diagnostic systems ; Heart diseases ; Heart Ventricles ; Humans ; Imaging ; Imaging techniques ; Internal Medicine ; Interventional Radiology ; Magnetic Resonance Imaging ; Medical diagnosis ; Medical imaging ; Medicine ; Medicine & Public Health ; Muscles ; Neuroradiology ; Phenotype ; Phenotypes ; Radiology ; Resonance ; Ultrasound ; Ventricle</subject><ispartof>European radiology, 2023-01, Vol.33 (1), p.270-282</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-15161b550a32d468af0129b2b8fc2fc79bbc5f9b9e7191c2d3d64877a4d97c9b3</citedby><cites>FETCH-LOGICAL-c474t-15161b550a32d468af0129b2b8fc2fc79bbc5f9b9e7191c2d3d64877a4d97c9b3</cites><orcidid>0000-0001-7842-6202</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-022-08958-2$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-022-08958-2$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35788758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cipriani, Alberto</creatorcontrib><creatorcontrib>Mattesi, Giulia</creatorcontrib><creatorcontrib>Bariani, Riccardo</creatorcontrib><creatorcontrib>Cecere, Annagrazia</creatorcontrib><creatorcontrib>Martini, Nicolò</creatorcontrib><creatorcontrib>De Michieli, Laura</creatorcontrib><creatorcontrib>Da Pozzo, Stefano</creatorcontrib><creatorcontrib>Corradin, Simone</creatorcontrib><creatorcontrib>De Conti, Giorgio</creatorcontrib><creatorcontrib>Zorzi, Alessandro</creatorcontrib><creatorcontrib>Motta, Raffaella</creatorcontrib><creatorcontrib>De Lazzari, Manuel</creatorcontrib><creatorcontrib>Bauce, Barbara</creatorcontrib><creatorcontrib>Iliceto, Sabino</creatorcontrib><creatorcontrib>Basso, Cristina</creatorcontrib><creatorcontrib>Corrado, Domenico</creatorcontrib><creatorcontrib>Perazzolo Marra, Martina</creatorcontrib><title>Cardiac magnetic resonance imaging of arrhythmogenic cardiomyopathy: evolving diagnostic perspectives</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Arrhythmogenic cardiomyopathy (ACM) is a genetically determined heart muscle disease characterized by fibro-fatty myocardial replacement, clinically associated with malignant ventricular arrhythmias and sudden cardiac death. Originally described a disease with a prevalent right ventricular (RV) involvement, subsequently two other phenotypes have been recognized, such as the
left dominant
and the
biventricular
phenotypes, for which a recent International Expert consensus document provided upgrade diagnostic criteria (the 2020 “Padua Criteria”). In this novel workup for the diagnosis of the entire spectrum of phenotypic variants of ACM, including left ventricular (LV) variants, cardiac magnetic resonance (CMR) has emerged as the cardiac imaging technique of choice, due to its capability of detailed morpho-functional and tissue characterization evaluation of both RV and LV. In this review, the key role of CMR in the diagnosis of ACM is outlined, including the supplemental value for the characterization of the disease variants. An ACM-specific CMR study protocol, as well as strengths and weaknesses of each imaging technique, is also provided.
Key Points
• Arrhythmogenic cardiomyopathy includes three different phenotypes: dominant right, biventricular, and dominant left.
• In 2020, diagnostic criteria have been updated and cardiac magnetic resonance has emerged as the cardiac imaging technique of choice.
• This aim of this review is to provide an update of the current state of art regarding the use of CMR in ACM, with a particular focus on novel diagnostic criteria, CMR protocols, and prognostic significance of CMR findings in ACM.</description><subject>Arrhythmogenic Right Ventricular Dysplasia - diagnostic imaging</subject><subject>Arrhythmogenic Right Ventricular Dysplasia - genetics</subject><subject>Cardiac</subject><subject>Cardiac muscle</subject><subject>Cardiomyopathy</subject><subject>Criteria</subject><subject>Death, Sudden, Cardiac - pathology</subject><subject>Diagnosis</subject><subject>Diagnostic Radiology</subject><subject>Diagnostic systems</subject><subject>Heart diseases</subject><subject>Heart Ventricles</subject><subject>Humans</subject><subject>Imaging</subject><subject>Imaging techniques</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical diagnosis</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Muscles</subject><subject>Neuroradiology</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Radiology</subject><subject>Resonance</subject><subject>Ultrasound</subject><subject>Ventricle</subject><issn>1432-1084</issn><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU9v3CAQxVHVqNmk_QI5VJZ66cUJYDCQQ6Vq1fyRVsolPSOMx16vbHDBu9J---Jsukl6yAnE_ObNPB5CFwRfEozFVcS4KHCOKc2xVFzm9ANaEFbQnGDJPr66n6KzGDcYY0WY-IROCy6kFFwuECxNqDtjs8G0DqbOZgGid8ZZyLr01rk2801mQljvp_XgW3CJsXOTH_Z-NNN6f53Bzve7GU1SrfNx1hkhxBHs1O0gfkYnjekjfHk-z9Hvm1-Py7t89XB7v_y5yi0TbMoJJyWpOMemoDUrpWkwoaqilWwsbaxQVWV5oyoFgihiaV3UJZNCGFYrYVVVnKMfB91xWw1QW3BTML0eQ7IS9tqbTr-tuG6tW7_TSqSpSiWB788Cwf_ZQpz00EULfW8c-G3UtJR8_nTKEvrtP3Tjt8Ele5oKzkqmJMOJogfKBh9jgOa4DMF6TlEfUtQpRf2Uoqap6etrG8eWf7EloDgAMZVcC-Fl9juyfwGit6rr</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Cipriani, Alberto</creator><creator>Mattesi, Giulia</creator><creator>Bariani, Riccardo</creator><creator>Cecere, Annagrazia</creator><creator>Martini, Nicolò</creator><creator>De Michieli, Laura</creator><creator>Da Pozzo, Stefano</creator><creator>Corradin, Simone</creator><creator>De Conti, Giorgio</creator><creator>Zorzi, Alessandro</creator><creator>Motta, Raffaella</creator><creator>De Lazzari, Manuel</creator><creator>Bauce, Barbara</creator><creator>Iliceto, Sabino</creator><creator>Basso, Cristina</creator><creator>Corrado, Domenico</creator><creator>Perazzolo Marra, Martina</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7842-6202</orcidid></search><sort><creationdate>20230101</creationdate><title>Cardiac magnetic resonance imaging of arrhythmogenic cardiomyopathy: evolving diagnostic perspectives</title><author>Cipriani, Alberto ; Mattesi, Giulia ; Bariani, Riccardo ; Cecere, Annagrazia ; Martini, Nicolò ; De Michieli, Laura ; Da Pozzo, Stefano ; Corradin, Simone ; De Conti, Giorgio ; Zorzi, Alessandro ; Motta, Raffaella ; De Lazzari, Manuel ; Bauce, Barbara ; Iliceto, Sabino ; Basso, Cristina ; Corrado, Domenico ; Perazzolo Marra, Martina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-15161b550a32d468af0129b2b8fc2fc79bbc5f9b9e7191c2d3d64877a4d97c9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Arrhythmogenic Right Ventricular Dysplasia - diagnostic imaging</topic><topic>Arrhythmogenic Right Ventricular Dysplasia - genetics</topic><topic>Cardiac</topic><topic>Cardiac muscle</topic><topic>Cardiomyopathy</topic><topic>Criteria</topic><topic>Death, Sudden, Cardiac - pathology</topic><topic>Diagnosis</topic><topic>Diagnostic Radiology</topic><topic>Diagnostic systems</topic><topic>Heart diseases</topic><topic>Heart Ventricles</topic><topic>Humans</topic><topic>Imaging</topic><topic>Imaging techniques</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical diagnosis</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Muscles</topic><topic>Neuroradiology</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Radiology</topic><topic>Resonance</topic><topic>Ultrasound</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cipriani, Alberto</creatorcontrib><creatorcontrib>Mattesi, Giulia</creatorcontrib><creatorcontrib>Bariani, Riccardo</creatorcontrib><creatorcontrib>Cecere, Annagrazia</creatorcontrib><creatorcontrib>Martini, Nicolò</creatorcontrib><creatorcontrib>De Michieli, Laura</creatorcontrib><creatorcontrib>Da Pozzo, Stefano</creatorcontrib><creatorcontrib>Corradin, Simone</creatorcontrib><creatorcontrib>De Conti, Giorgio</creatorcontrib><creatorcontrib>Zorzi, Alessandro</creatorcontrib><creatorcontrib>Motta, Raffaella</creatorcontrib><creatorcontrib>De Lazzari, Manuel</creatorcontrib><creatorcontrib>Bauce, Barbara</creatorcontrib><creatorcontrib>Iliceto, Sabino</creatorcontrib><creatorcontrib>Basso, Cristina</creatorcontrib><creatorcontrib>Corrado, Domenico</creatorcontrib><creatorcontrib>Perazzolo Marra, Martina</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cipriani, Alberto</au><au>Mattesi, Giulia</au><au>Bariani, Riccardo</au><au>Cecere, Annagrazia</au><au>Martini, Nicolò</au><au>De Michieli, Laura</au><au>Da Pozzo, Stefano</au><au>Corradin, Simone</au><au>De Conti, Giorgio</au><au>Zorzi, Alessandro</au><au>Motta, Raffaella</au><au>De Lazzari, Manuel</au><au>Bauce, Barbara</au><au>Iliceto, Sabino</au><au>Basso, Cristina</au><au>Corrado, Domenico</au><au>Perazzolo Marra, Martina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac magnetic resonance imaging of arrhythmogenic cardiomyopathy: evolving diagnostic perspectives</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>33</volume><issue>1</issue><spage>270</spage><epage>282</epage><pages>270-282</pages><issn>1432-1084</issn><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Arrhythmogenic cardiomyopathy (ACM) is a genetically determined heart muscle disease characterized by fibro-fatty myocardial replacement, clinically associated with malignant ventricular arrhythmias and sudden cardiac death. Originally described a disease with a prevalent right ventricular (RV) involvement, subsequently two other phenotypes have been recognized, such as the
left dominant
and the
biventricular
phenotypes, for which a recent International Expert consensus document provided upgrade diagnostic criteria (the 2020 “Padua Criteria”). In this novel workup for the diagnosis of the entire spectrum of phenotypic variants of ACM, including left ventricular (LV) variants, cardiac magnetic resonance (CMR) has emerged as the cardiac imaging technique of choice, due to its capability of detailed morpho-functional and tissue characterization evaluation of both RV and LV. In this review, the key role of CMR in the diagnosis of ACM is outlined, including the supplemental value for the characterization of the disease variants. An ACM-specific CMR study protocol, as well as strengths and weaknesses of each imaging technique, is also provided.
Key Points
• Arrhythmogenic cardiomyopathy includes three different phenotypes: dominant right, biventricular, and dominant left.
• In 2020, diagnostic criteria have been updated and cardiac magnetic resonance has emerged as the cardiac imaging technique of choice.
• This aim of this review is to provide an update of the current state of art regarding the use of CMR in ACM, with a particular focus on novel diagnostic criteria, CMR protocols, and prognostic significance of CMR findings in ACM.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35788758</pmid><doi>10.1007/s00330-022-08958-2</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-7842-6202</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Arrhythmogenic Right Ventricular Dysplasia - diagnostic imaging Arrhythmogenic Right Ventricular Dysplasia - genetics Cardiac Cardiac muscle Cardiomyopathy Criteria Death, Sudden, Cardiac - pathology Diagnosis Diagnostic Radiology Diagnostic systems Heart diseases Heart Ventricles Humans Imaging Imaging techniques Internal Medicine Interventional Radiology Magnetic Resonance Imaging Medical diagnosis Medical imaging Medicine Medicine & Public Health Muscles Neuroradiology Phenotype Phenotypes Radiology Resonance Ultrasound Ventricle |
| title | Cardiac magnetic resonance imaging of arrhythmogenic cardiomyopathy: evolving diagnostic perspectives |
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