Whole-body MRI in oncology: can a single anatomic T2 Dixon sequence replace the combination of T1 and STIR sequences to detect skeletal metastasis and myeloma?
Objectives To compare the diagnostic accuracy of a single T2 Dixon sequence to the combination T1+STIR as anatomical sequences used for detecting tumoral bone marrow lesions in whole-body MRI (WB-MRI) examinations. Methods Between January 2019 and January 2020, seventy-two consecutive patients (55 m...
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| Veröffentlicht in: | European radiology 2023-01, Vol.33 (1), p.244-257 |
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| creator | Chiabai, Ophelye Van Nieuwenhove, Sandy Vekemans, Marie-Christiane Tombal, Bertrand Peeters, Frank Wuts, Joris Triqueneaux, Perrine Omoumi, Patrick Kirchgesner, Thomas Michoux, Nicolas Lecouvet, Frédéric E. |
| description | Objectives
To compare the diagnostic accuracy of a single T2 Dixon sequence to the combination T1+STIR as anatomical sequences used for detecting tumoral bone marrow lesions in whole-body MRI (WB-MRI) examinations.
Methods
Between January 2019 and January 2020, seventy-two consecutive patients (55 men, 17 women, median age = 66 years) with solid (prostate, breast, neuroendocrine) cancers at high risk of metastasis or proven multiple myeloma (MM) prospectively underwent a WB-MRI examination including coronal T1, STIR, T2 Dixon and axial diffusion-weighted imaging sequences. Two radiologists independently assessed the combination of T1+STIR sequences and the fat+water reconstructions from the T2 Dixon sequence. The reference standard was established by consensus reading of WB-MRI and concurrent imaging available at baseline and at 6 months. Repeatability and reproducibility of MRI scores (presence and semi-quantitative count of lesions), image quality (SNR: signal-to-noise, CNR: contrast-to-noise, CRR: contrast-to-reference ratios), and diagnostic characteristics (Se: sensitivity, Sp: specificity, Acc: accuracy) were assessed
per
-skeletal region and
per
-patient.
Results
Repeatability and reproducibility were at least good regardless of the score, region, and protocol (0.67 ≤ AC1 ≤ 0.98). CRR was higher on T2 Dixon fat compared to T1 (
p
< 0.0001) and on T2 Dixon water compared to STIR (
p
= 0.0128). In the
per
-patient analysis, Acc of the T2 Dixon fat+water was higher than that of T1+STIR for the senior reader (Acc = +0.027 [+0.025; +0.029],
p
< 0.0001) and lower for the junior reader (Acc = −0.029 [−0.031; −0.027],
p
< 0.0001).
Conclusions
A single T2 Dixon sequence with fat+water reconstructions offers similar reproducibility and diagnostic accuracy as the recommended combination of T1+STIR sequences and can be used for skeletal screening in oncology, allowing significant time-saving.
Key Points
• Replacement of the standard anatomic T1 + STIR WB-MRI protocol by a single T2 Dixon sequence drastically shortens the examination time without loss of diagnostic accuracy.
• A protocol based on fat + water reconstructions from a single T2 Dixon sequence offers similar inter-reader agreement and a higher contrast-to-reference ratio for detecting lesions compared to the standard T1 + STIR protocol.
• Differences in the accuracy between the two protocols are marginal (+ 3% in favor of the T2 Dixon with the senior reader; −3% against the T2 Dixon with the junior r |
| doi_str_mv | 10.1007/s00330-022-09007-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9755082</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2698632233</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-923acdbb0e4d7c891cb92ad0c5247dac86abd4784a1fd868fe0566d441f75f713</originalsourceid><addsrcrecordid>eNp9kc1u1DAUhSMEoqXwAiyQJTZsAtc_iR0WVKj8jVSEVAaxtBz7ZsbFsYc4g5in4VUxnTIUFkiWr-X7nWNfnap6SOEpBZDPMgDnUANjNXTlola3qmMqOKspKHH7xvmoupfzJQB0VMi71RFvOtZwJY6rH5_XKWDdJ7cj7y8WxEeSok0hrXbPiTWRGJJ9XAUkJpo5jd6SJSOv_PcUScavW4wWyYSbYEqd10hsGntfUF-ANJAlLUJHPi4XFwc-kzkRhzPameQvGHA2gYxlz2X5fCUYdxjSaE7vV3cGEzI-uK4n1ac3r5dn7-rzD28XZy_PayukmOuOcWNd3wMKJ63qqO07ZhzYhgnpjFWt6Z2QShg6ONWqAaFpWycEHWQzSMpPqhd73822H9FZjPNkgt5MfjTTTifj9d-d6Nd6lb7pTjYNKFYMnlwbTKmMmWc9-mwxBBMxbbNmbadazhjnBX38D3qZtlMs42kmG9E2AAwKxfaUnVLOEw6Hz1DQv_LX-_x1yV9f5a9VET26OcZB8jvwAvA9kEsrrnD68_Z_bH8CFvy9XQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2754650020</pqid></control><display><type>article</type><title>Whole-body MRI in oncology: can a single anatomic T2 Dixon sequence replace the combination of T1 and STIR sequences to detect skeletal metastasis and myeloma?</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Chiabai, Ophelye ; Van Nieuwenhove, Sandy ; Vekemans, Marie-Christiane ; Tombal, Bertrand ; Peeters, Frank ; Wuts, Joris ; Triqueneaux, Perrine ; Omoumi, Patrick ; Kirchgesner, Thomas ; Michoux, Nicolas ; Lecouvet, Frédéric E.</creator><creatorcontrib>Chiabai, Ophelye ; Van Nieuwenhove, Sandy ; Vekemans, Marie-Christiane ; Tombal, Bertrand ; Peeters, Frank ; Wuts, Joris ; Triqueneaux, Perrine ; Omoumi, Patrick ; Kirchgesner, Thomas ; Michoux, Nicolas ; Lecouvet, Frédéric E.</creatorcontrib><description>Objectives
To compare the diagnostic accuracy of a single T2 Dixon sequence to the combination T1+STIR as anatomical sequences used for detecting tumoral bone marrow lesions in whole-body MRI (WB-MRI) examinations.
Methods
Between January 2019 and January 2020, seventy-two consecutive patients (55 men, 17 women, median age = 66 years) with solid (prostate, breast, neuroendocrine) cancers at high risk of metastasis or proven multiple myeloma (MM) prospectively underwent a WB-MRI examination including coronal T1, STIR, T2 Dixon and axial diffusion-weighted imaging sequences. Two radiologists independently assessed the combination of T1+STIR sequences and the fat+water reconstructions from the T2 Dixon sequence. The reference standard was established by consensus reading of WB-MRI and concurrent imaging available at baseline and at 6 months. Repeatability and reproducibility of MRI scores (presence and semi-quantitative count of lesions), image quality (SNR: signal-to-noise, CNR: contrast-to-noise, CRR: contrast-to-reference ratios), and diagnostic characteristics (Se: sensitivity, Sp: specificity, Acc: accuracy) were assessed
per
-skeletal region and
per
-patient.
Results
Repeatability and reproducibility were at least good regardless of the score, region, and protocol (0.67 ≤ AC1 ≤ 0.98). CRR was higher on T2 Dixon fat compared to T1 (
p
< 0.0001) and on T2 Dixon water compared to STIR (
p
= 0.0128). In the
per
-patient analysis, Acc of the T2 Dixon fat+water was higher than that of T1+STIR for the senior reader (Acc = +0.027 [+0.025; +0.029],
p
< 0.0001) and lower for the junior reader (Acc = −0.029 [−0.031; −0.027],
p
< 0.0001).
Conclusions
A single T2 Dixon sequence with fat+water reconstructions offers similar reproducibility and diagnostic accuracy as the recommended combination of T1+STIR sequences and can be used for skeletal screening in oncology, allowing significant time-saving.
Key Points
• Replacement of the standard anatomic T1 + STIR WB-MRI protocol by a single T2 Dixon sequence drastically shortens the examination time without loss of diagnostic accuracy.
• A protocol based on fat + water reconstructions from a single T2 Dixon sequence offers similar inter-reader agreement and a higher contrast-to-reference ratio for detecting lesions compared to the standard T1 + STIR protocol.
• Differences in the accuracy between the two protocols are marginal (+ 3% in favor of the T2 Dixon with the senior reader; −3% against the T2 Dixon with the junior reader).</description><identifier>ISSN: 1432-1084</identifier><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-022-09007-8</identifier><identifier>PMID: 35925384</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Accuracy ; Aged ; Axial diffusion ; Bone marrow ; Conserved sequence ; Diagnostic Radiology ; Diagnostic systems ; Female ; Humans ; Image contrast ; Image quality ; Imaging ; Internal Medicine ; Interventional Radiology ; Lesions ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Medical imaging ; Medicine ; Medicine & Public Health ; Metastases ; Metastasis ; Multiple myeloma ; Multiple Myeloma - diagnostic imaging ; Neuroendocrine tumors ; Neuroradiology ; Oncology ; Prostate ; Radiology ; Reproducibility ; Reproducibility of Results ; Signal quality ; Signal to noise ratio ; Ultrasound ; Water ; Whole Body Imaging - methods</subject><ispartof>European radiology, 2023-01, Vol.33 (1), p.244-257</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-923acdbb0e4d7c891cb92ad0c5247dac86abd4784a1fd868fe0566d441f75f713</citedby><cites>FETCH-LOGICAL-c474t-923acdbb0e4d7c891cb92ad0c5247dac86abd4784a1fd868fe0566d441f75f713</cites><orcidid>0000-0003-3568-3254</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-022-09007-8$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-022-09007-8$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35925384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chiabai, Ophelye</creatorcontrib><creatorcontrib>Van Nieuwenhove, Sandy</creatorcontrib><creatorcontrib>Vekemans, Marie-Christiane</creatorcontrib><creatorcontrib>Tombal, Bertrand</creatorcontrib><creatorcontrib>Peeters, Frank</creatorcontrib><creatorcontrib>Wuts, Joris</creatorcontrib><creatorcontrib>Triqueneaux, Perrine</creatorcontrib><creatorcontrib>Omoumi, Patrick</creatorcontrib><creatorcontrib>Kirchgesner, Thomas</creatorcontrib><creatorcontrib>Michoux, Nicolas</creatorcontrib><creatorcontrib>Lecouvet, Frédéric E.</creatorcontrib><title>Whole-body MRI in oncology: can a single anatomic T2 Dixon sequence replace the combination of T1 and STIR sequences to detect skeletal metastasis and myeloma?</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objectives
To compare the diagnostic accuracy of a single T2 Dixon sequence to the combination T1+STIR as anatomical sequences used for detecting tumoral bone marrow lesions in whole-body MRI (WB-MRI) examinations.
Methods
Between January 2019 and January 2020, seventy-two consecutive patients (55 men, 17 women, median age = 66 years) with solid (prostate, breast, neuroendocrine) cancers at high risk of metastasis or proven multiple myeloma (MM) prospectively underwent a WB-MRI examination including coronal T1, STIR, T2 Dixon and axial diffusion-weighted imaging sequences. Two radiologists independently assessed the combination of T1+STIR sequences and the fat+water reconstructions from the T2 Dixon sequence. The reference standard was established by consensus reading of WB-MRI and concurrent imaging available at baseline and at 6 months. Repeatability and reproducibility of MRI scores (presence and semi-quantitative count of lesions), image quality (SNR: signal-to-noise, CNR: contrast-to-noise, CRR: contrast-to-reference ratios), and diagnostic characteristics (Se: sensitivity, Sp: specificity, Acc: accuracy) were assessed
per
-skeletal region and
per
-patient.
Results
Repeatability and reproducibility were at least good regardless of the score, region, and protocol (0.67 ≤ AC1 ≤ 0.98). CRR was higher on T2 Dixon fat compared to T1 (
p
< 0.0001) and on T2 Dixon water compared to STIR (
p
= 0.0128). In the
per
-patient analysis, Acc of the T2 Dixon fat+water was higher than that of T1+STIR for the senior reader (Acc = +0.027 [+0.025; +0.029],
p
< 0.0001) and lower for the junior reader (Acc = −0.029 [−0.031; −0.027],
p
< 0.0001).
Conclusions
A single T2 Dixon sequence with fat+water reconstructions offers similar reproducibility and diagnostic accuracy as the recommended combination of T1+STIR sequences and can be used for skeletal screening in oncology, allowing significant time-saving.
Key Points
• Replacement of the standard anatomic T1 + STIR WB-MRI protocol by a single T2 Dixon sequence drastically shortens the examination time without loss of diagnostic accuracy.
• A protocol based on fat + water reconstructions from a single T2 Dixon sequence offers similar inter-reader agreement and a higher contrast-to-reference ratio for detecting lesions compared to the standard T1 + STIR protocol.
• Differences in the accuracy between the two protocols are marginal (+ 3% in favor of the T2 Dixon with the senior reader; −3% against the T2 Dixon with the junior reader).</description><subject>Accuracy</subject><subject>Aged</subject><subject>Axial diffusion</subject><subject>Bone marrow</subject><subject>Conserved sequence</subject><subject>Diagnostic Radiology</subject><subject>Diagnostic systems</subject><subject>Female</subject><subject>Humans</subject><subject>Image contrast</subject><subject>Image quality</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Lesions</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Multiple myeloma</subject><subject>Multiple Myeloma - diagnostic imaging</subject><subject>Neuroendocrine tumors</subject><subject>Neuroradiology</subject><subject>Oncology</subject><subject>Prostate</subject><subject>Radiology</subject><subject>Reproducibility</subject><subject>Reproducibility of Results</subject><subject>Signal quality</subject><subject>Signal to noise ratio</subject><subject>Ultrasound</subject><subject>Water</subject><subject>Whole Body Imaging - methods</subject><issn>1432-1084</issn><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc1u1DAUhSMEoqXwAiyQJTZsAtc_iR0WVKj8jVSEVAaxtBz7ZsbFsYc4g5in4VUxnTIUFkiWr-X7nWNfnap6SOEpBZDPMgDnUANjNXTlola3qmMqOKspKHH7xvmoupfzJQB0VMi71RFvOtZwJY6rH5_XKWDdJ7cj7y8WxEeSok0hrXbPiTWRGJJ9XAUkJpo5jd6SJSOv_PcUScavW4wWyYSbYEqd10hsGntfUF-ANJAlLUJHPi4XFwc-kzkRhzPameQvGHA2gYxlz2X5fCUYdxjSaE7vV3cGEzI-uK4n1ac3r5dn7-rzD28XZy_PayukmOuOcWNd3wMKJ63qqO07ZhzYhgnpjFWt6Z2QShg6ONWqAaFpWycEHWQzSMpPqhd73822H9FZjPNkgt5MfjTTTifj9d-d6Nd6lb7pTjYNKFYMnlwbTKmMmWc9-mwxBBMxbbNmbadazhjnBX38D3qZtlMs42kmG9E2AAwKxfaUnVLOEw6Hz1DQv_LX-_x1yV9f5a9VET26OcZB8jvwAvA9kEsrrnD68_Z_bH8CFvy9XQ</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Chiabai, Ophelye</creator><creator>Van Nieuwenhove, Sandy</creator><creator>Vekemans, Marie-Christiane</creator><creator>Tombal, Bertrand</creator><creator>Peeters, Frank</creator><creator>Wuts, Joris</creator><creator>Triqueneaux, Perrine</creator><creator>Omoumi, Patrick</creator><creator>Kirchgesner, Thomas</creator><creator>Michoux, Nicolas</creator><creator>Lecouvet, Frédéric E.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3568-3254</orcidid></search><sort><creationdate>20230101</creationdate><title>Whole-body MRI in oncology: can a single anatomic T2 Dixon sequence replace the combination of T1 and STIR sequences to detect skeletal metastasis and myeloma?</title><author>Chiabai, Ophelye ; Van Nieuwenhove, Sandy ; Vekemans, Marie-Christiane ; Tombal, Bertrand ; Peeters, Frank ; Wuts, Joris ; Triqueneaux, Perrine ; Omoumi, Patrick ; Kirchgesner, Thomas ; Michoux, Nicolas ; Lecouvet, Frédéric E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-923acdbb0e4d7c891cb92ad0c5247dac86abd4784a1fd868fe0566d441f75f713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Accuracy</topic><topic>Aged</topic><topic>Axial diffusion</topic><topic>Bone marrow</topic><topic>Conserved sequence</topic><topic>Diagnostic Radiology</topic><topic>Diagnostic systems</topic><topic>Female</topic><topic>Humans</topic><topic>Image contrast</topic><topic>Image quality</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Lesions</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Multiple myeloma</topic><topic>Multiple Myeloma - diagnostic imaging</topic><topic>Neuroendocrine tumors</topic><topic>Neuroradiology</topic><topic>Oncology</topic><topic>Prostate</topic><topic>Radiology</topic><topic>Reproducibility</topic><topic>Reproducibility of Results</topic><topic>Signal quality</topic><topic>Signal to noise ratio</topic><topic>Ultrasound</topic><topic>Water</topic><topic>Whole Body Imaging - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chiabai, Ophelye</creatorcontrib><creatorcontrib>Van Nieuwenhove, Sandy</creatorcontrib><creatorcontrib>Vekemans, Marie-Christiane</creatorcontrib><creatorcontrib>Tombal, Bertrand</creatorcontrib><creatorcontrib>Peeters, Frank</creatorcontrib><creatorcontrib>Wuts, Joris</creatorcontrib><creatorcontrib>Triqueneaux, Perrine</creatorcontrib><creatorcontrib>Omoumi, Patrick</creatorcontrib><creatorcontrib>Kirchgesner, Thomas</creatorcontrib><creatorcontrib>Michoux, Nicolas</creatorcontrib><creatorcontrib>Lecouvet, Frédéric E.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chiabai, Ophelye</au><au>Van Nieuwenhove, Sandy</au><au>Vekemans, Marie-Christiane</au><au>Tombal, Bertrand</au><au>Peeters, Frank</au><au>Wuts, Joris</au><au>Triqueneaux, Perrine</au><au>Omoumi, Patrick</au><au>Kirchgesner, Thomas</au><au>Michoux, Nicolas</au><au>Lecouvet, Frédéric E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Whole-body MRI in oncology: can a single anatomic T2 Dixon sequence replace the combination of T1 and STIR sequences to detect skeletal metastasis and myeloma?</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>33</volume><issue>1</issue><spage>244</spage><epage>257</epage><pages>244-257</pages><issn>1432-1084</issn><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objectives
To compare the diagnostic accuracy of a single T2 Dixon sequence to the combination T1+STIR as anatomical sequences used for detecting tumoral bone marrow lesions in whole-body MRI (WB-MRI) examinations.
Methods
Between January 2019 and January 2020, seventy-two consecutive patients (55 men, 17 women, median age = 66 years) with solid (prostate, breast, neuroendocrine) cancers at high risk of metastasis or proven multiple myeloma (MM) prospectively underwent a WB-MRI examination including coronal T1, STIR, T2 Dixon and axial diffusion-weighted imaging sequences. Two radiologists independently assessed the combination of T1+STIR sequences and the fat+water reconstructions from the T2 Dixon sequence. The reference standard was established by consensus reading of WB-MRI and concurrent imaging available at baseline and at 6 months. Repeatability and reproducibility of MRI scores (presence and semi-quantitative count of lesions), image quality (SNR: signal-to-noise, CNR: contrast-to-noise, CRR: contrast-to-reference ratios), and diagnostic characteristics (Se: sensitivity, Sp: specificity, Acc: accuracy) were assessed
per
-skeletal region and
per
-patient.
Results
Repeatability and reproducibility were at least good regardless of the score, region, and protocol (0.67 ≤ AC1 ≤ 0.98). CRR was higher on T2 Dixon fat compared to T1 (
p
< 0.0001) and on T2 Dixon water compared to STIR (
p
= 0.0128). In the
per
-patient analysis, Acc of the T2 Dixon fat+water was higher than that of T1+STIR for the senior reader (Acc = +0.027 [+0.025; +0.029],
p
< 0.0001) and lower for the junior reader (Acc = −0.029 [−0.031; −0.027],
p
< 0.0001).
Conclusions
A single T2 Dixon sequence with fat+water reconstructions offers similar reproducibility and diagnostic accuracy as the recommended combination of T1+STIR sequences and can be used for skeletal screening in oncology, allowing significant time-saving.
Key Points
• Replacement of the standard anatomic T1 + STIR WB-MRI protocol by a single T2 Dixon sequence drastically shortens the examination time without loss of diagnostic accuracy.
• A protocol based on fat + water reconstructions from a single T2 Dixon sequence offers similar inter-reader agreement and a higher contrast-to-reference ratio for detecting lesions compared to the standard T1 + STIR protocol.
• Differences in the accuracy between the two protocols are marginal (+ 3% in favor of the T2 Dixon with the senior reader; −3% against the T2 Dixon with the junior reader).</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35925384</pmid><doi>10.1007/s00330-022-09007-8</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-3568-3254</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | European radiology, 2023-01, Vol.33 (1), p.244-257 |
| issn | 1432-1084 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9755082 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Accuracy Aged Axial diffusion Bone marrow Conserved sequence Diagnostic Radiology Diagnostic systems Female Humans Image contrast Image quality Imaging Internal Medicine Interventional Radiology Lesions Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical imaging Medicine Medicine & Public Health Metastases Metastasis Multiple myeloma Multiple Myeloma - diagnostic imaging Neuroendocrine tumors Neuroradiology Oncology Prostate Radiology Reproducibility Reproducibility of Results Signal quality Signal to noise ratio Ultrasound Water Whole Body Imaging - methods |
| title | Whole-body MRI in oncology: can a single anatomic T2 Dixon sequence replace the combination of T1 and STIR sequences to detect skeletal metastasis and myeloma? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T02%3A16%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Whole-body%20MRI%20in%20oncology:%20can%20a%20single%20anatomic%20T2%20Dixon%20sequence%20replace%20the%20combination%20of%20T1%20and%20STIR%20sequences%20to%20detect%20skeletal%20metastasis%20and%20myeloma?&rft.jtitle=European%20radiology&rft.au=Chiabai,%20Ophelye&rft.date=2023-01-01&rft.volume=33&rft.issue=1&rft.spage=244&rft.epage=257&rft.pages=244-257&rft.issn=1432-1084&rft.eissn=1432-1084&rft_id=info:doi/10.1007/s00330-022-09007-8&rft_dat=%3Cproquest_pubme%3E2698632233%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2754650020&rft_id=info:pmid/35925384&rfr_iscdi=true |