Oxidative Reactions Catalyzed by Hydrogen Peroxide Produced by Streptococcus pneumoniae and Other Streptococci Cause the Release and Degradation of Heme from Hemoglobin

Streptococcus pneumoniae (Spn) strains cause pneumonia that kills millions every year worldwide. Spn produces Ply, a hemolysin that lyses erythrocytes releasing hemoglobin, and also produces the pro-oxidant hydrogen peroxide (Spn-H O ) during growth. The hallmark of the pathophysiology of hemolytic...

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Veröffentlicht in:	Infection and immunity 2022-12, Vol.90 (12), p.e0047122
Hauptverfasser:	Alibayov, Babek, Scasny, Anna, Khan, Faidad, Creel, Aidan, Smith, Perriann, Vidal, Ana G Jop, Fitisemanu, Fa'alataitaua M, Padilla-Benavides, Teresita, Weiser, Jeffrey N, Vidal, Jorge E
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriology Catalysis Heme - metabolism Hemoglobins - metabolism Hydrogen Peroxide - pharmacology Molecular Pathogenesis Oxidation-Reduction Oxidative Stress Oxyhemoglobins - metabolism Streptococcus - metabolism Streptococcus pneumoniae - genetics Streptococcus pneumoniae - metabolism
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