Prohibitin 1 regulates mtDNA release and downstream inflammatory responses

Exposure of mitochondrial DNA (mtDNA) to the cytosol activates innate immune responses. But the mechanisms by which mtDNA crosses the inner mitochondrial membrane are unknown. Here, we found that the inner mitochondrial membrane protein prohibitin 1 (PHB1) plays a critical role in mtDNA release by r...

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Veröffentlicht in:	The EMBO journal 2022-12, Vol.41 (24), p.e111173-n/a
Hauptverfasser:	Liu, Hao, Fan, Hualin, He, Pengcheng, Zhuang, Haixia, Liu, Xiao, Chen, Meiting, Zhong, Wenwei, Zhang, Yi, Zhen, Cien, Li, Yanling, Jiang, Huilin, Meng, Tian, Xu, Yiming, Zhao, Guojun, Feng, Du
Format:	Artikel
Sprache:	eng
Schlagworte:	AFG3L2 Animals ATPases Associated with Diverse Cellular Activities - metabolism Cyclosporins Cytosol DNA, Mitochondrial - genetics EMBO19 EMBO57 Homeostasis Humans Immune response Inflammation Innate immunity Interleukins Leukocytes (mononuclear) Leukocytes, Mononuclear - metabolism Lipopolysaccharides Macrophages Membrane permeability Membrane proteins Membranes Metalloendopeptidases - metabolism Mice MIMP Mitochondrial DNA Mitochondrial Permeability Transition Pore mtDNA Neonates Oligomerization Peripheral blood mononuclear cells Permeability PHB Prohibitin Prohibitins - metabolism Proteins Repressor Proteins - metabolism Sepsis SPG7 Stresses
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