Optimized Multi-Attribute Method Workflow Addressing Missed Cleavages and Chromatographic Tailing/Carry-Over of Hydrophobic Peptides

Peptide mapping by liquid chromatography mass spectrometry (LC-MS) and the related multi-attribute method (MAM) are well-established analytical tools for verification of the primary structure and mapping/quantitation of co- and post-translational modifications (PTMs) or product quality attributes in...

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Veröffentlicht in:	Analytical chemistry (Washington) 2022-12, Vol.94 (49), p.17195-17204
Hauptverfasser:	Kristensen, Dan B., Ørgaard, Martin, Sloth, Trine M., Christoffersen, Nanna S., Leth-Espensen, Katrine Z., Jensen, Pernille F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Analytical chemistry Biopharmaceuticals Chemistry Chromatography Chromatography, Liquid - methods Data interpretation Digestion High temperature Hydrophobicity Liquid chromatography Low temperature Mass spectrometry Mass spectroscopy Peptide mapping Peptide Mapping - methods Peptides Peptides - chemistry Post-translation Proteolysis Quality management Quantitation Reproducibility of Results Switching Tailings Tandem Mass Spectrometry - methods Workflow
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