Discovery of new potent lysine specific histone demythelase-1 inhibitors (LSD-1) using structure based and ligand based molecular modelling and machine learning

Lysine-specific histone demethylase 1 (LSD-1) is an epigenetic enzyme that oxidatively cleaves methyl groups from monomethyl and dimethyl Lys4 of histone H3 and is highly overexpressed in different types of cancer. Therefore, it has been widely recognized as a promising therapeutic target for cancer...

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Veröffentlicht in:	RSC advances 2022-12, Vol.12 (55), p.35873-35895
Hauptverfasser:	Alabed, Shada J, Zihlif, Malek, Taha, Mutasem
Format:	Artikel
Sprache:	eng
Schlagworte:	CAD Cancer Chemistry Computer aided design Crystallography Genetic algorithms Histones Inhibitors Ligands Lysine Machine learning Modelling Molecular structure Pharmacology
Online-Zugang:	Volltext
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