CEND1 deficiency induces mitochondrial dysfunction and cognitive impairment in Alzheimer’s disease

Alzheimer’s disease (AD) is the most common form of neurodegenerative disease featured with memory loss and cognitive function impairments. Chronic mitochondrial stress is a vital pathogenic factor for AD and finally leads to massive neuronal death. However, the underlying mechanism is unclear. By p...

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Veröffentlicht in:	Cell death and differentiation 2022-12, Vol.29 (12), p.2417-2428
Hauptverfasser:	Xie, Wenting, Guo, Dong, Li, Jieyin, Yue, Lei, Kang, Qi, Chen, Guimiao, Zhou, Tingwen, Wang, Han, Zhuang, Kai, Leng, Lige, Li, Huifang, Chen, Zhenyi, Gao, Weiwei, Zhang, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/2 13/51 14/28 38 45/77 631/378/2611 631/80 64 64/60 82/58 82/80 Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - metabolism Animals Apoptosis Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Cell differentiation Cognitive ability Cognitive Dysfunction - genetics Cognitive Dysfunction - metabolism Disease Models, Animal Dynamin Life Sciences Membrane Proteins - metabolism Mice Mice, Transgenic Mitochondria Mitochondria - metabolism Nerve Tissue Proteins - metabolism Neurodegenerative diseases Neurodegenerative Diseases - metabolism Proteins Proteomics Stem Cells
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