Designed Ankyrin Repeat Proteins as a tool box for analyzing p63

The function of the p53 transcription factor family is dependent on several folded domains. In addition to a DNA-binding domain, members of this family contain an oligomerization domain. p63 and p73 also contain a C-terminal Sterile α-motif domain. Inhibition of most transcription factors is difficu...

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Veröffentlicht in:	Cell death and differentiation 2022-12, Vol.29 (12), p.2445-2458
Hauptverfasser:	Strubel, Alexander, Münick, Philipp, Chaikuad, Apirat, Dreier, Birgit, Schaefer, Jonas, Gebel, Jakob, Osterburg, Christian, Tuppi, Marcel, Schäfer, Birgit, Knapp, Stefan, Plückthun, Andreas, Dötsch, Volker
Format:	Artikel
Sprache:	eng
Schlagworte:	14 14/1 631/535/1266 631/92/56 82 Ankyrins Apoptosis Biochemistry Biomedical and Life Sciences Cell Biology Cell culture Cell Cycle Analysis Deoxyribonucleic acid Designed Ankyrin Repeat Proteins DNA DNA - chemistry DNA-Binding Proteins - metabolism Interfaces Investigations Kinases Life Sciences Nuclear Proteins - metabolism Oligomerization p53 Protein Protein structure Proteins Quality control Stem Cells Tissue culture Transcription factors Transcription Factors - metabolism Tumor Protein p73 - metabolism Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins - metabolism
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