Cathepsin D Drives the Formation of Hybrid Insulin Peptides Relevant to the Pathogenesis of Type 1 Diabetes

Hybrid insulin peptides (HIPs) form in pancreatic β-cells through the formation of peptide bonds between proinsulin fragments and other peptides. HIPs have been identified in pancreatic islets by mass spectrometry and are targeted by CD4 T cells in patients with type 1 diabetes (T1D) as well as by p...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2022-12, Vol.71 (12), p.2793-2803
Hauptverfasser:	Crawford, Samantha A, Wiles, Timothy A, Wenzlau, Janet M, Powell, Roger L, Barbour, Gene, Dang, Mylinh, Groegler, Jason, Barra, Jessie M, Burnette, KaLia S, Hohenstein, Anita C, Baker, Rocky L, Tse, Hubert M, Haskins, Kathryn, Delong, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Beta cells Cathepsin D Cathepsin L CD4 antigen CD4-Positive T-Lymphocytes Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - metabolism Genetics/Genomes/Proteomics/Metabolomics Insulin Insulin, Regular, Human Lymphocytes Lymphocytes T Mass spectroscopy Mice Mice, Inbred NOD Pancreas Pathogenesis Peptides Proteinase Proteolysis Proteomics Therapeutic targets
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