Inducible expression of human β-defensin 2 by Fusobacterium nucleatum in oral epithelial cells : Multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier

Human gingival epithelial cells (HGE) express two antimicrobial peptides of the beta-defensin family, human beta-defensin 1 (hBD-1) and hBD-2, as well as cytokines and chemokines that contribute to innate immunity. In the present study, the expression and transcriptional regulation of hBD-2 was exam...

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Veröffentlicht in:	Infection and immunity 2000-05, Vol.68 (5), p.2907-2915
Hauptverfasser:	KRISANAPRAKORNKIT, S, KIMBALL, J. R, WEINBERG, A, DARVEAU, R. P, BAINBRIDGE, B. W, DALE, B. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Bacteriology beta-Defensins Biological and medical sciences Cells, Cultured Cycloheximide - pharmacology Dactinomycin - pharmacology Defensins Epithelial Cells - drug effects Epithelial Cells - immunology Fluorescent Antibody Technique, Indirect Fundamental and applied biological sciences. Psychology Fusobacterium nucleatum - immunology Gene Expression Regulation - drug effects Gingiva - cytology Gingiva - immunology Gingiva - pathology Host Response and Inflammation Humans Kinetics Lipopolysaccharides - immunology Lipopolysaccharides - pharmacology Microbiology Mitogens - immunology Mitogens - pharmacology Nucleic Acid Synthesis Inhibitors - pharmacology Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Peptides - metabolism Porphyromonas gingivalis - immunology Protein Synthesis Inhibitors - pharmacology Proteins - genetics Proteins - metabolism RNA, Messenger Signal Transduction Tetradecanoylphorbol Acetate - immunology Tetradecanoylphorbol Acetate - pharmacology Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - pharmacology Up-Regulation
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