Insights into the Spectrum of Activity and Mechanism of Action of MGB-BP‑3

MGB-BP-3 is a potential first-in-class antibiotic, a Strathclyde Minor Groove Binder (S-MGB), that has successfully completed Phase IIa clinical trials for the treatment of Clostridioides difficile associated disease. Its precise mechanism of action and the origin of limited activity against Gram-ne...

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Veröffentlicht in:	ACS infectious diseases 2022-12, Vol.8 (12), p.2552-2563
Hauptverfasser:	Hind, Charlotte, Clifford, Melanie, Woolley, Charlotte, Harmer, Jane, McGee, Leah M. C., Tyson-Hirst, Izaak, Tait, Henry J., Brooke, Daniel P., Dancer, Stephanie J., Hunter, Iain S., Suckling, Colin J., Beveridge, Rebecca, Parkinson, John A., Sutton, J. Mark, Scott, Fraser J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Escherichia coli
Online-Zugang:	Volltext
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