Molecular Basis for the Substrate Promiscuity of Isopentenyl Phosphate Kinase from Candidatus methanomethylophilus alvus

Isopentenyl phosphate kinases (IPKs) catalyze the ATP-dependent phosphorylation of isopentenyl monophosphate (IP) to isopentenyl diphosphate (IPP) in the alternate mevalonate pathways of the archaea and plant cytoplasm. In recent years, IPKs have also been employed in artificial biosynthetic pathway...

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Veröffentlicht in:	ACS chemical biology 2022-01, Vol.17 (1), p.85-102
Hauptverfasser:	Johnson, Bryce P, Kumar, Vikas, Scull, Erin M, Thomas, Leonard M, Bourne, Christina R, Singh, Shanteri
Format:	Artikel
Sprache:	eng
Schlagworte:	Archaea - enzymology Archaeal Proteins - genetics Archaeal Proteins - metabolism Gene Expression Regulation, Archaeal Gene Expression Regulation, Enzymologic Genome, Archaeal Models, Molecular Mutation Protein Conformation Protein Kinases Substrate Specificity
Online-Zugang:	Volltext
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