Perinatal outcomes of intrahepatic cholestasis of pregnancy from two birth cohorts: A population-based study
Background Intrahepatic cholestasis of pregnancy (ICP) is a complex liver disease with varying incidence worldwide. We compared ICP incidence and pregnancy outcomes with outcomes for normal pregnant controls. Methods We conducted a retrospective data analysis of perinatal registry data for the years...
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| Veröffentlicht in: | Obstetric medicine 2022-12, Vol.15 (4), p.248-252 |
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| creator | Al-Obaidly, Sawsan Salama, Husam Olukade, Tawa AlQubaisi, Mai Bayo, Arabo Al Rifai, Hilal |
| description | Background
Intrahepatic cholestasis of pregnancy (ICP) is a complex liver disease with varying incidence worldwide. We compared ICP incidence and pregnancy outcomes with outcomes for normal pregnant controls.
Methods
We conducted a retrospective data analysis of perinatal registry data for the years 2011 and 2017 to compare the following outcome measures: stillbirths, labour induction, gestational diabetes, pre-eclampsia, antepartum haemorrhage, postpartum haemorrhage, preterm births, low Apgar score, acute neonatal respiratory morbidity, meconium aspiration and in-hospital neonatal death.
Results
The incidence of ICP was 8 per 1000 births from a total 31,493 singleton births with more cases in 2017 than in 2011. Women with ICP were almost six times more likely to have labour induced including significantly more moderate preterm births (defined as between 32 weeks and 36 weeks and 6 days of gestation)) seen more in 2011 than in 2017.
Conclusion
Women with ICP showed higher incidence of moderate preterm birth and induced labour but favourable maternal and neonatal outcomes. |
| doi_str_mv | 10.1177/1753495X211058321 |
| format | Article |
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Intrahepatic cholestasis of pregnancy (ICP) is a complex liver disease with varying incidence worldwide. We compared ICP incidence and pregnancy outcomes with outcomes for normal pregnant controls.
Methods
We conducted a retrospective data analysis of perinatal registry data for the years 2011 and 2017 to compare the following outcome measures: stillbirths, labour induction, gestational diabetes, pre-eclampsia, antepartum haemorrhage, postpartum haemorrhage, preterm births, low Apgar score, acute neonatal respiratory morbidity, meconium aspiration and in-hospital neonatal death.
Results
The incidence of ICP was 8 per 1000 births from a total 31,493 singleton births with more cases in 2017 than in 2011. Women with ICP were almost six times more likely to have labour induced including significantly more moderate preterm births (defined as between 32 weeks and 36 weeks and 6 days of gestation)) seen more in 2011 than in 2017.
Conclusion
Women with ICP showed higher incidence of moderate preterm birth and induced labour but favourable maternal and neonatal outcomes.</description><identifier>ISSN: 1753-495X</identifier><identifier>EISSN: 1753-4968</identifier><identifier>DOI: 10.1177/1753495X211058321</identifier><identifier>PMID: 36523882</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Apgar score ; Clinical outcomes ; Gallbladder diseases ; Gestational diabetes ; Original ; Population-based studies ; Preeclampsia ; Pregnancy ; Premature birth</subject><ispartof>Obstetric medicine, 2022-12, Vol.15 (4), p.248-252</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021.</rights><rights>The Author(s) 2021 2021 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-d4aca4b4d7c6361ce6f9dfbfb84aae8a9f3cf7b59aa076d78c9784734d61d5823</citedby><cites>FETCH-LOGICAL-c423t-d4aca4b4d7c6361ce6f9dfbfb84aae8a9f3cf7b59aa076d78c9784734d61d5823</cites><orcidid>0000-0001-6058-3437 ; 0000-0002-6595-5022</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745599/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745599/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,21800,27905,27906,43602,43603,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36523882$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al-Obaidly, Sawsan</creatorcontrib><creatorcontrib>Salama, Husam</creatorcontrib><creatorcontrib>Olukade, Tawa</creatorcontrib><creatorcontrib>AlQubaisi, Mai</creatorcontrib><creatorcontrib>Bayo, Arabo</creatorcontrib><creatorcontrib>Al Rifai, Hilal</creatorcontrib><title>Perinatal outcomes of intrahepatic cholestasis of pregnancy from two birth cohorts: A population-based study</title><title>Obstetric medicine</title><addtitle>Obstetric Medicine</addtitle><description>Background
Intrahepatic cholestasis of pregnancy (ICP) is a complex liver disease with varying incidence worldwide. We compared ICP incidence and pregnancy outcomes with outcomes for normal pregnant controls.
Methods
We conducted a retrospective data analysis of perinatal registry data for the years 2011 and 2017 to compare the following outcome measures: stillbirths, labour induction, gestational diabetes, pre-eclampsia, antepartum haemorrhage, postpartum haemorrhage, preterm births, low Apgar score, acute neonatal respiratory morbidity, meconium aspiration and in-hospital neonatal death.
Results
The incidence of ICP was 8 per 1000 births from a total 31,493 singleton births with more cases in 2017 than in 2011. Women with ICP were almost six times more likely to have labour induced including significantly more moderate preterm births (defined as between 32 weeks and 36 weeks and 6 days of gestation)) seen more in 2011 than in 2017.
Conclusion
Women with ICP showed higher incidence of moderate preterm birth and induced labour but favourable maternal and neonatal outcomes.</description><subject>Apgar score</subject><subject>Clinical outcomes</subject><subject>Gallbladder diseases</subject><subject>Gestational diabetes</subject><subject>Original</subject><subject>Population-based studies</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Premature birth</subject><issn>1753-495X</issn><issn>1753-4968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kU9vFSEUxYnR2Fr9AG4MiRs30w4DDODCpGn8lzTRhSbdkTvAvKGZGUZgat63l9dXn63GFYT7O4d7chB6SepTQoQ4I4JTpvhVQ0jNJW3II3S8e6uYauXjw51fHaFnKV3XdctpQ5-iI9ryhkrZHKPxq4t-hgwjDms2YXIJhx77OUcY3ALZG2yGMLqUIfnb2RLdZobZbHEfw4Tzz4A7H_OATRhCzOktPsdLWNaxiMNcdZCcxSmvdvscPelhTO7F3XmCvn94_-3iU3X55ePni_PLyrCG5soyMMA6ZoVpaUuMa3tl-67vJANwElRPTS86rgBq0VohjRKSCcpsSyyXDT1B7_a-y9pNzhq3SzPqJfoJ4lYH8PrhZPaD3oQbrQTjXKli8ObOIIYfa8muJ5-MG0eYXViTbgTnXEhS79DXf6HXYY1ziVcoJmTZh9BCkT1lYkgpuv6wDKn1rkv9T5dF8-p-ioPid3kFON0DCTbuz7f_d_wFLgSqiA</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Al-Obaidly, Sawsan</creator><creator>Salama, Husam</creator><creator>Olukade, Tawa</creator><creator>AlQubaisi, Mai</creator><creator>Bayo, Arabo</creator><creator>Al Rifai, Hilal</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6058-3437</orcidid><orcidid>https://orcid.org/0000-0002-6595-5022</orcidid></search><sort><creationdate>20221201</creationdate><title>Perinatal outcomes of intrahepatic cholestasis of pregnancy from two birth cohorts: A population-based study</title><author>Al-Obaidly, Sawsan ; Salama, Husam ; Olukade, Tawa ; AlQubaisi, Mai ; Bayo, Arabo ; Al Rifai, Hilal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-d4aca4b4d7c6361ce6f9dfbfb84aae8a9f3cf7b59aa076d78c9784734d61d5823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Apgar score</topic><topic>Clinical outcomes</topic><topic>Gallbladder diseases</topic><topic>Gestational diabetes</topic><topic>Original</topic><topic>Population-based studies</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Premature birth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al-Obaidly, Sawsan</creatorcontrib><creatorcontrib>Salama, Husam</creatorcontrib><creatorcontrib>Olukade, Tawa</creatorcontrib><creatorcontrib>AlQubaisi, Mai</creatorcontrib><creatorcontrib>Bayo, Arabo</creatorcontrib><creatorcontrib>Al Rifai, Hilal</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Obstetric medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Obaidly, Sawsan</au><au>Salama, Husam</au><au>Olukade, Tawa</au><au>AlQubaisi, Mai</au><au>Bayo, Arabo</au><au>Al Rifai, Hilal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perinatal outcomes of intrahepatic cholestasis of pregnancy from two birth cohorts: A population-based study</atitle><jtitle>Obstetric medicine</jtitle><addtitle>Obstetric Medicine</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>15</volume><issue>4</issue><spage>248</spage><epage>252</epage><pages>248-252</pages><issn>1753-495X</issn><eissn>1753-4968</eissn><abstract>Background
Intrahepatic cholestasis of pregnancy (ICP) is a complex liver disease with varying incidence worldwide. We compared ICP incidence and pregnancy outcomes with outcomes for normal pregnant controls.
Methods
We conducted a retrospective data analysis of perinatal registry data for the years 2011 and 2017 to compare the following outcome measures: stillbirths, labour induction, gestational diabetes, pre-eclampsia, antepartum haemorrhage, postpartum haemorrhage, preterm births, low Apgar score, acute neonatal respiratory morbidity, meconium aspiration and in-hospital neonatal death.
Results
The incidence of ICP was 8 per 1000 births from a total 31,493 singleton births with more cases in 2017 than in 2011. Women with ICP were almost six times more likely to have labour induced including significantly more moderate preterm births (defined as between 32 weeks and 36 weeks and 6 days of gestation)) seen more in 2011 than in 2017.
Conclusion
Women with ICP showed higher incidence of moderate preterm birth and induced labour but favourable maternal and neonatal outcomes.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>36523882</pmid><doi>10.1177/1753495X211058321</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-6058-3437</orcidid><orcidid>https://orcid.org/0000-0002-6595-5022</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Obstetric medicine, 2022-12, Vol.15 (4), p.248-252 |
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| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SAGE Complete A-Z List; PubMed Central |
| subjects | Apgar score Clinical outcomes Gallbladder diseases Gestational diabetes Original Population-based studies Preeclampsia Pregnancy Premature birth |
| title | Perinatal outcomes of intrahepatic cholestasis of pregnancy from two birth cohorts: A population-based study |
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