Visuo‐spatial learning and memory impairments in the 5xFAD mouse model of Alzheimer's disease: Effects of age, sex, albinism, and motor impairments

The 5xFAD mouse model of Alzheimer's disease (AD) rapidly develops AD‐related neuro‐behavioral pathology. Learning and memory impairments in 5xFAD mice, however, are not always replicated and the size of impairments varies considerably across studies. To examine possible sources of this variabi...

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Veröffentlicht in:	Genes, brain and behavior brain and behavior, 2022-04, Vol.21 (4), p.e12794-n/a
Hauptverfasser:	O'Leary, Timothy P., Brown, Richard E.
Format:	Artikel
Sprache:	eng
Schlagworte:	5xFAD Age aging Albinism Albinism - complications Alzheimer Disease - complications Alzheimer Disease - genetics Alzheimer's disease Amyloid beta-Protein Precursor - genetics Animals dementia Disease Models, Animal Female learning and memory Male Maze Learning Mice Mice, Transgenic motor ability Motor Disorders - complications Motor skill learning neurodegeneration Neurodegenerative diseases Original Reproducibility of Results Reversal learning Sex Sex differences Spatial discrimination learning Spatial Learning Spatial memory Transgenes visual ability visuo‐spatial
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