From Oxetane to Thietane: Extending the Antiviral Spectrum of 2′-Spirocyclic Uridines by Substituting Oxygen with Sulfur

In continuation of our efforts of finding novel nucleoside inhibitors for the treatment of viral diseases, we initiated a discovery research program aimed at identifying novel nucleos­(t)­ide inhibitors for emerging diseases like Dengue and Chikungunya. Based on the previously reported 2′-spiro-oxet...

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Veröffentlicht in:	ACS medicinal chemistry letters 2022-12, Vol.13 (12), p.1879-1884
Hauptverfasser:	Grosse, Sandrine, Tahri, Abdellah, Raboisson, Pierre, Houpis, Yannis, Stoops, Bart, Jacoby, Edgar, Neefs, Jean-Marc, Van Loock, Marnix, Goethals, Olivia, Geluykens, Peggy, Bonfanti, Jean-François, Jonckers, Tim H. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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