Development of Gilteritinib-Based Chimeric Small Molecules that Potently Induce Degradation of FLT3-ITD Protein

Internal tandem duplication (ITD) in the gene encoding FMS-like tyrosine kinase 3 (FLT3) (FLT3-ITD) is the most frequently observed mutation in acute myeloid leukemia (AML). Currently approved FLT3 kinase inhibitors have high efficacy, but drug resistance caused by reactivation of FLT3 kinase activi...

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Veröffentlicht in:	ACS medicinal chemistry letters 2022-12, Vol.13 (12), p.1885-1891
Hauptverfasser:	Ohoka, Nobumichi, Suzuki, Masanori, Uchida, Takuya, Tsuji, Genichiro, Tsukumo, Yoshinori, Yoshida, Masayuki, Inoue, Takao, Demizu, Yosuke, Ohki, Hitoshi, Naito, Mikihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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