IL-4 receptor blockade is a global repressor of naïve B cell development and responses in a dupilumab-treated patient

Here, we report a case of atopic dermatitis (AD) in a patient who received biweekly doses of dupilumab, an antibody against the IL-4 receptor α chain (IL-4Rα). Single cell RNA-sequencing showed that naïve B cells expressed the highest levels of IL4R compared to other B cell subpopulations. Compared...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2022-11, Vol.244, p.109130-109130, Article 109130
Hauptverfasser:	Mountz, John D., Gao, Min, Ponder, David M., Liu, Shanrun, Sun, Chiao-Wang, Alduraibi, Fatima, Sullivan, Kathryn, Pat, Betty, Dell'Italia, Louis J., Hsu, Hui-Chen
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized COVID-19 Drug Treatment COVID-19 vaccination COVID-19 Vaccines Dupilumab Humans IL-4 receptor Interleukin-4 Memory B cells Naive B cells Receptors, Antigen, B-Cell Receptors, Interleukin-4 RNA
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