Bronchodilators in Tobacco-Exposed Persons with Symptoms and Preserved Lung Function
This trial involving symptomatic, tobacco-exposed persons with preserved lung function on spirometry showed no benefit to the use of dual bronchodilator therapy.
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| Veröffentlicht in: | The New England journal of medicine 2022-09, Vol.387 (13), p.1173-1184 |
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| container_title | The New England journal of medicine |
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| creator | Han, MeiLan K. Ye, Wen Wang, Di White, Emily Arjomandi, Mehrdad Barjaktarevic, Igor Z. Brown, Stacey-Ann Buhr, Russell G. Comellas, Alejandro P. Cooper, Christopher B. Criner, Gerard J. Dransfield, Mark T. Drescher, Frank Folz, Rodney J. Hansel, Nadia N. Kalhan, Ravi Kaner, Robert J. Kanner, Richard E. Krishnan, Jerry A. Lazarus, Stephen C. Maddipati, Veeranna Martinez, Fernando J. Mathews, Anne Meldrum, Catherine McEvoy, Charlene Nyunoya, Toru Rogers, Linda Stringer, William W. Wendt, Christine H. Wise, Robert A. Wisniewski, Stephen R. Sciurba, Frank C. Woodruff, Prescott G. |
| description | This trial involving symptomatic, tobacco-exposed persons with preserved lung function on spirometry showed no benefit to the use of dual bronchodilator therapy. |
| doi_str_mv | 10.1056/NEJMoa2204752 |
| format | Article |
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All rights reserved.</rights><rights>Copyright © 2022 Massachusetts Medical Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-a577bf7bdb80ec6708adf3453960dce96239a4814cb4ca4b5bb3ac1b6cc8ec213</citedby><cites>FETCH-LOGICAL-c445t-a577bf7bdb80ec6708adf3453960dce96239a4814cb4ca4b5bb3ac1b6cc8ec213</cites><orcidid>0000-0001-6159-7435 ; 0000-0001-5525-4778 ; 0000-0002-9207-1820 ; 0000-0003-1521-7520</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa2204752$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa2204752$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>230,314,776,780,881,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36066078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, MeiLan K.</creatorcontrib><creatorcontrib>Ye, Wen</creatorcontrib><creatorcontrib>Wang, Di</creatorcontrib><creatorcontrib>White, Emily</creatorcontrib><creatorcontrib>Arjomandi, Mehrdad</creatorcontrib><creatorcontrib>Barjaktarevic, Igor Z.</creatorcontrib><creatorcontrib>Brown, Stacey-Ann</creatorcontrib><creatorcontrib>Buhr, Russell G.</creatorcontrib><creatorcontrib>Comellas, Alejandro P.</creatorcontrib><creatorcontrib>Cooper, Christopher B.</creatorcontrib><creatorcontrib>Criner, Gerard J.</creatorcontrib><creatorcontrib>Dransfield, Mark T.</creatorcontrib><creatorcontrib>Drescher, Frank</creatorcontrib><creatorcontrib>Folz, Rodney J.</creatorcontrib><creatorcontrib>Hansel, Nadia N.</creatorcontrib><creatorcontrib>Kalhan, Ravi</creatorcontrib><creatorcontrib>Kaner, Robert J.</creatorcontrib><creatorcontrib>Kanner, Richard E.</creatorcontrib><creatorcontrib>Krishnan, Jerry A.</creatorcontrib><creatorcontrib>Lazarus, Stephen C.</creatorcontrib><creatorcontrib>Maddipati, Veeranna</creatorcontrib><creatorcontrib>Martinez, Fernando J.</creatorcontrib><creatorcontrib>Mathews, Anne</creatorcontrib><creatorcontrib>Meldrum, Catherine</creatorcontrib><creatorcontrib>McEvoy, Charlene</creatorcontrib><creatorcontrib>Nyunoya, Toru</creatorcontrib><creatorcontrib>Rogers, Linda</creatorcontrib><creatorcontrib>Stringer, William W.</creatorcontrib><creatorcontrib>Wendt, Christine H.</creatorcontrib><creatorcontrib>Wise, Robert A.</creatorcontrib><creatorcontrib>Wisniewski, Stephen R.</creatorcontrib><creatorcontrib>Sciurba, Frank C.</creatorcontrib><creatorcontrib>Woodruff, Prescott G.</creatorcontrib><creatorcontrib>RETHINC Study Group</creatorcontrib><title>Bronchodilators in Tobacco-Exposed Persons with Symptoms and Preserved Lung Function</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>This trial involving symptomatic, tobacco-exposed persons with preserved lung function on spirometry showed no benefit to the use of dual bronchodilator therapy.</description><subject>Adrenergic beta-2 Receptor Agonists - 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drug therapy</subject><subject>Pulmonary Disease, Chronic Obstructive - etiology</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Respiration</subject><subject>Respiratory function</subject><subject>Smoking</subject><subject>Spirometry</subject><subject>Tobacco</subject><subject>Tobacco Products</subject><subject>Treatment Outcome</subject><issn>0028-4793</issn><issn>1533-4406</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10UtLxDAQB_Agiq6Po1cpiOClmjRp0lwEXdYX6wNczyFJs26XNqlJu-q3N7IqKphLDvObPzMMALsIHiGY0-Pb0fWNk1kGCcuzFTBAOcYpIZCuggGEWZESxvEG2AxhDuNDhK-DDUwhpZAVAzA5887qmSurWnbOh6SyycQpqbVLR6-tC6ZM7o0PzobkpepmycNb03auCYm0seJNMH4Rzbi3T8l5b3VXObsN1qayDmbn898Cj-ejyfAyHd9dXA1Px6kmJO9SmTOmpkyVqoBGUwYLWU4xyTGnsNSG0wxzSQpEtCJaEpUrhaVGimpdGJ0hvAVOlrltrxoTW2znZS1aXzXSvwknK_G7YquZeHILwRlBBaUx4PAzwLvn3oRONFXQpq6lNa4PImMIcsrjRJHu_6Fz13sb1_tQHCKMChJVulTauxC8mX4Pg6D4uJf4da_o935u8K2_DhTBwRI0TRDWzJt_gt4B8red1w</recordid><startdate>20220929</startdate><enddate>20220929</enddate><creator>Han, MeiLan K.</creator><creator>Ye, Wen</creator><creator>Wang, Di</creator><creator>White, Emily</creator><creator>Arjomandi, Mehrdad</creator><creator>Barjaktarevic, Igor Z.</creator><creator>Brown, Stacey-Ann</creator><creator>Buhr, Russell G.</creator><creator>Comellas, Alejandro P.</creator><creator>Cooper, Christopher B.</creator><creator>Criner, Gerard J.</creator><creator>Dransfield, Mark T.</creator><creator>Drescher, Frank</creator><creator>Folz, Rodney J.</creator><creator>Hansel, Nadia N.</creator><creator>Kalhan, Ravi</creator><creator>Kaner, Robert J.</creator><creator>Kanner, Richard E.</creator><creator>Krishnan, Jerry A.</creator><creator>Lazarus, Stephen C.</creator><creator>Maddipati, Veeranna</creator><creator>Martinez, Fernando J.</creator><creator>Mathews, Anne</creator><creator>Meldrum, Catherine</creator><creator>McEvoy, Charlene</creator><creator>Nyunoya, Toru</creator><creator>Rogers, Linda</creator><creator>Stringer, William W.</creator><creator>Wendt, Christine H.</creator><creator>Wise, Robert A.</creator><creator>Wisniewski, Stephen R.</creator><creator>Sciurba, Frank C.</creator><creator>Woodruff, Prescott G.</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6159-7435</orcidid><orcidid>https://orcid.org/0000-0001-5525-4778</orcidid><orcidid>https://orcid.org/0000-0002-9207-1820</orcidid><orcidid>https://orcid.org/0000-0003-1521-7520</orcidid></search><sort><creationdate>20220929</creationdate><title>Bronchodilators in Tobacco-Exposed Persons with Symptoms and Preserved Lung Function</title><author>Han, MeiLan K. ; Ye, Wen ; Wang, Di ; White, Emily ; Arjomandi, Mehrdad ; Barjaktarevic, Igor Z. ; Brown, Stacey-Ann ; Buhr, Russell G. ; Comellas, Alejandro P. ; Cooper, Christopher B. ; Criner, Gerard J. ; Dransfield, Mark T. ; Drescher, Frank ; Folz, Rodney J. ; Hansel, Nadia N. ; Kalhan, Ravi ; Kaner, Robert J. ; Kanner, Richard E. ; Krishnan, Jerry A. ; Lazarus, Stephen C. ; Maddipati, Veeranna ; Martinez, Fernando J. ; Mathews, Anne ; Meldrum, Catherine ; McEvoy, Charlene ; Nyunoya, Toru ; Rogers, Linda ; Stringer, William W. ; Wendt, Christine H. ; Wise, Robert A. ; Wisniewski, Stephen R. ; Sciurba, Frank C. ; Woodruff, Prescott G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-a577bf7bdb80ec6708adf3453960dce96239a4814cb4ca4b5bb3ac1b6cc8ec213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adrenergic beta-2 Receptor Agonists - 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| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2022-09, Vol.387 (13), p.1173-1184 |
| issn | 0028-4793 1533-4406 1533-4406 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9741866 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Adrenergic beta-2 Receptor Agonists - therapeutic use Anti-Bacterial Agents - therapeutic use Antibiotics Bronchodilator Agents - therapeutic use Bronchodilators Chronic obstructive pulmonary disease Clinical Medicine Clinical Medicine General Clinical significance COPD Coronaviruses COVID-19 Critical Care Critical Care General Drug dosages Dyspnea FDA approval Forced Expiratory Volume Glucocorticoids Glucocorticoids - therapeutic use Glycopyrrolate Humans Lung Lung diseases Obstructive lung disease Outpatient-Based Clinical Medicine Pandemics Placebos Pulmonary Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonary Disease, Chronic Obstructive - etiology Pulmonary Disease, Chronic Obstructive - physiopathology Respiration Respiratory function Smoking Spirometry Tobacco Tobacco Products Treatment Outcome |
| title | Bronchodilators in Tobacco-Exposed Persons with Symptoms and Preserved Lung Function |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T22%3A34%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bronchodilators%20in%20Tobacco-Exposed%20Persons%20with%20Symptoms%20and%20Preserved%20Lung%20Function&rft.jtitle=The%20New%20England%20journal%20of%20medicine&rft.au=Han,%20MeiLan%20K.&rft.aucorp=RETHINC%20Study%20Group&rft.date=2022-09-29&rft.volume=387&rft.issue=13&rft.spage=1173&rft.epage=1184&rft.pages=1173-1184&rft.issn=0028-4793&rft.eissn=1533-4406&rft_id=info:doi/10.1056/NEJMoa2204752&rft_dat=%3Cproquest_pubme%3E2710969539%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2719013184&rft_id=info:pmid/36066078&rfr_iscdi=true |