Adenosine 2A Receptor Activation Amplifies Ibrutinib Antiplatelet Effect; Implications in Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia patients have an increased bleeding risk with the introduction of Bruton tyrosine kinase (BTK) inhibitors. BTK is a signaling effector downstream of the platelet GPVI receptor. Innate platelet dysfunction in CLL patients and the contribution of the leukemia microenvironm...

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Veröffentlicht in:	Cancers 2022-11, Vol.14 (23), p.5750
Hauptverfasser:	Elaskalani, Omar, Gilmore, Grace, Hagger, Madison, Baker, Ross I, Metharom, Pat
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine AKT protein Antibodies Bleeding Blood platelets Bruton's tyrosine kinase CD73 antigen Cell receptors Chronic lymphocytic leukemia Collagen Drug therapy Extracellular signal-regulated kinase Flow cytometry Health aspects Hypoxia Kinases Leukemia Lymphocytes B Microenvironments Nucleotidase Phosphorylation Platelet aggregation Protein-tyrosine kinase Receptor mechanisms Signal transduction Syk protein Thrombosis
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