Porphyromonas gingivalis Fimbriae Induce Osteoclastogenesis via Toll-like Receptors in RAW264 Cells

The effect of Mfa1 fimbriae of on the progression of bone resorption remains unclear, especially compared with another fimbriae, FimA. We investigated the effect of Mfa1 on osteoclastogenesis together with FimA. We also investigated the role of Toll-like receptors (TLRs) in Mfa1 recognition during o...

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Veröffentlicht in:	International journal of molecular sciences 2022-12, Vol.23 (23), p.15293
Hauptverfasser:	Suzuki, Yuki, Kikuchi, Takeshi, Goto, Hisashi, Takayanagi, Yuhei, Kawamura, Shotaro, Sawada, Noritaka, Naiki, Yoshikazu, Kondo, Hisataka, Hayashi, Jun-Ichiro, Hasegawa, Yoshiaki, Mitani, Akio
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid phosphatase (tartrate-resistant) Acid resistance Animals Bacteria Bone marrow Bone Resorption Cell Differentiation Cytokines Differentiation Fimbriae, Bacterial - genetics Gelatinase B Gene expression Gum disease Mice Osteoclastogenesis Osteoclasts Osteogenesis Pathogens Periodontal disease Periodontal diseases Pili Porphyromonas gingivalis RANK Ligand - metabolism RAW 264.7 Cells Recognition siRNA TLR2 protein TLR4 protein Toll-like receptors TRANCE protein Transfection Tumor necrosis factor-TNF Virulence
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