JAK2/STAT3 pathway mediates neuroprotective and pro-angiogenic treatment effects of adult human neural stem cells in middle cerebral artery occlusion stroke animal models

Mismatches between pre-clinical and clinical results of stem cell therapeutics for ischemic stroke limit their clinical applicability. To overcome these discrepancies, precise planning of pre-clinical experiments that can be translated to clinical trials and the scientific elucidation of treatment m...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2022-11, Vol.14 (22), p.8944-8969
Hauptverfasser:	Ha, Geun-Hyoung, Kim, Eun Ji, Park, Jee Soo, Kim, Ji Eun, Nam, Hyun, Yeon, Je Young, Lee, Sun-Ho, Lee, Kyunghoon, Kim, Chung Kwon, Joo, Kyeung Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inducing Agents Animals Disease Models, Animal Humans Infarction, Middle Cerebral Artery - drug therapy Ischemic Stroke - therapy Janus Kinase 2 - metabolism Models, Animal Neural Stem Cells - metabolism Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Rats Research Paper STAT3 Transcription Factor - metabolism Stroke - drug therapy
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