Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes

Atopic dermatitis (AD) is a chronic inflammatory skin disease with a profound negative impact on patients' quality of life. Four known secondary fungal metabolites were found in the chemical study of the Antarctic fungus sp. SF-7343, including 14-methoxyalternate C ( ), 5'-methoxy-6-methyl...

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Veröffentlicht in:	International journal of molecular sciences 2022-11, Vol.23 (23), p.14642
Hauptverfasser:	Dong, Linsha, Cao, Thao Quyen, Liu, Zhiming, Tuan, Nguyen Quoc, Kim, Youn-Chul, Sohn, Jae Hak, Yim, Joung Han, Lee, Dong-Sung, Oh, Hyuncheol
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - therapeutic use Atopic dermatitis Carbon Cell adhesion Chemokines Cytokines Cytokines - metabolism Dermatitis, Atopic - metabolism Eczema Fungi Humans Immune system Inflammation Intercellular adhesion molecule 1 Interferon Interleukin 6 Interleukin 8 Janus kinase 2 Janus Kinase 2 - metabolism Keratinocytes Keratinocytes - metabolism Metabolites NF-kappa B - metabolism NF-κB protein Nuclear transport Pathogenesis Pleosporales Quality of Life RANTES Signal transduction Skin diseases Stat3 protein STAT3 Transcription Factor - metabolism Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α γ-Interferon
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