Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes
Atopic dermatitis (AD) is a chronic inflammatory skin disease with a profound negative impact on patients' quality of life. Four known secondary fungal metabolites were found in the chemical study of the Antarctic fungus sp. SF-7343, including 14-methoxyalternate C ( ), 5'-methoxy-6-methyl...
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| Veröffentlicht in: | International journal of molecular sciences 2022-11, Vol.23 (23), p.14642 |
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| creator | Dong, Linsha Cao, Thao Quyen Liu, Zhiming Tuan, Nguyen Quoc Kim, Youn-Chul Sohn, Jae Hak Yim, Joung Han Lee, Dong-Sung Oh, Hyuncheol |
| description | Atopic dermatitis (AD) is a chronic inflammatory skin disease with a profound negative impact on patients' quality of life. Four known secondary fungal metabolites were found in the chemical study of the Antarctic fungus
sp. SF-7343, including 14-methoxyalternate C (
), 5'-methoxy-6-methyl-biphenyl-3,4,3'-triol (
), 3,8,10-trihydroxy-4-methoxy-6-methylbenzocoumarin (
), and alternariol monomethyl ether (
). Additionally, we identified the skin anti-inflammatory composition from the SF-7343 strain. Interleukin-8 and -6 Screening results showed that compound
inhibited IL-8 and IL-6 in tumor necrosis factor-α/interferon-γ stimulated HaCaT cells. Compound
showed inhibitory effects on MDC and RANTES. It also downregulated the expression of intercellular adhesion molecule-1 (ICAM-1) and upregulated the expression of involucrin. The results of the mechanistic study showed that compound
inhibited the nuclear translocation of nuclear factor-kappa B p65 and STAT3. In conclusion, this study demonstrates the potential of the Antarctic fungal strain SF-7343 as a bioactive resource to inhibit skin inflammation, such as AD. |
| doi_str_mv | 10.3390/ijms232314642 |
| format | Article |
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sp. SF-7343, including 14-methoxyalternate C (
), 5'-methoxy-6-methyl-biphenyl-3,4,3'-triol (
), 3,8,10-trihydroxy-4-methoxy-6-methylbenzocoumarin (
), and alternariol monomethyl ether (
). Additionally, we identified the skin anti-inflammatory composition from the SF-7343 strain. Interleukin-8 and -6 Screening results showed that compound
inhibited IL-8 and IL-6 in tumor necrosis factor-α/interferon-γ stimulated HaCaT cells. Compound
showed inhibitory effects on MDC and RANTES. It also downregulated the expression of intercellular adhesion molecule-1 (ICAM-1) and upregulated the expression of involucrin. The results of the mechanistic study showed that compound
inhibited the nuclear translocation of nuclear factor-kappa B p65 and STAT3. In conclusion, this study demonstrates the potential of the Antarctic fungal strain SF-7343 as a bioactive resource to inhibit skin inflammation, such as AD.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms232314642</identifier><identifier>PMID: 36498968</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Anti-Inflammatory Agents - therapeutic use ; Atopic dermatitis ; Carbon ; Cell adhesion ; Chemokines ; Cytokines ; Cytokines - metabolism ; Dermatitis, Atopic - metabolism ; Eczema ; Fungi ; Humans ; Immune system ; Inflammation ; Intercellular adhesion molecule 1 ; Interferon ; Interleukin 6 ; Interleukin 8 ; Janus kinase 2 ; Janus Kinase 2 - metabolism ; Keratinocytes ; Keratinocytes - metabolism ; Metabolites ; NF-kappa B - metabolism ; NF-κB protein ; Nuclear transport ; Pathogenesis ; Pleosporales ; Quality of Life ; RANTES ; Signal transduction ; Skin diseases ; Stat3 protein ; STAT3 Transcription Factor - metabolism ; Tumor Necrosis Factor-alpha - metabolism ; Tumor necrosis factor-α ; γ-Interferon</subject><ispartof>International journal of molecular sciences, 2022-11, Vol.23 (23), p.14642</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3302-4393e029468083d6d8406c10a29a0baa04c75edc71df2b578a5b8955d7489fa63</citedby><cites>FETCH-LOGICAL-c3302-4393e029468083d6d8406c10a29a0baa04c75edc71df2b578a5b8955d7489fa63</cites><orcidid>0000-0002-9234-7567 ; 0000-0002-9704-1807 ; 0009-0001-6170-5747</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740060/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740060/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36498968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dong, Linsha</creatorcontrib><creatorcontrib>Cao, Thao Quyen</creatorcontrib><creatorcontrib>Liu, Zhiming</creatorcontrib><creatorcontrib>Tuan, Nguyen Quoc</creatorcontrib><creatorcontrib>Kim, Youn-Chul</creatorcontrib><creatorcontrib>Sohn, Jae Hak</creatorcontrib><creatorcontrib>Yim, Joung Han</creatorcontrib><creatorcontrib>Lee, Dong-Sung</creatorcontrib><creatorcontrib>Oh, Hyuncheol</creatorcontrib><title>Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Atopic dermatitis (AD) is a chronic inflammatory skin disease with a profound negative impact on patients' quality of life. Four known secondary fungal metabolites were found in the chemical study of the Antarctic fungus
sp. SF-7343, including 14-methoxyalternate C (
), 5'-methoxy-6-methyl-biphenyl-3,4,3'-triol (
), 3,8,10-trihydroxy-4-methoxy-6-methylbenzocoumarin (
), and alternariol monomethyl ether (
). Additionally, we identified the skin anti-inflammatory composition from the SF-7343 strain. Interleukin-8 and -6 Screening results showed that compound
inhibited IL-8 and IL-6 in tumor necrosis factor-α/interferon-γ stimulated HaCaT cells. Compound
showed inhibitory effects on MDC and RANTES. It also downregulated the expression of intercellular adhesion molecule-1 (ICAM-1) and upregulated the expression of involucrin. The results of the mechanistic study showed that compound
inhibited the nuclear translocation of nuclear factor-kappa B p65 and STAT3. In conclusion, this study demonstrates the potential of the Antarctic fungal strain SF-7343 as a bioactive resource to inhibit skin inflammation, such as AD.</description><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Atopic dermatitis</subject><subject>Carbon</subject><subject>Cell adhesion</subject><subject>Chemokines</subject><subject>Cytokines</subject><subject>Cytokines - metabolism</subject><subject>Dermatitis, Atopic - metabolism</subject><subject>Eczema</subject><subject>Fungi</subject><subject>Humans</subject><subject>Immune system</subject><subject>Inflammation</subject><subject>Intercellular adhesion molecule 1</subject><subject>Interferon</subject><subject>Interleukin 6</subject><subject>Interleukin 8</subject><subject>Janus kinase 2</subject><subject>Janus Kinase 2 - metabolism</subject><subject>Keratinocytes</subject><subject>Keratinocytes - metabolism</subject><subject>Metabolites</subject><subject>NF-kappa B - metabolism</subject><subject>NF-κB protein</subject><subject>Nuclear transport</subject><subject>Pathogenesis</subject><subject>Pleosporales</subject><subject>Quality of Life</subject><subject>RANTES</subject><subject>Signal transduction</subject><subject>Skin diseases</subject><subject>Stat3 protein</subject><subject>STAT3 Transcription Factor - metabolism</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Tumor necrosis factor-α</subject><subject>γ-Interferon</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkk1vEzEQhlcIREvhyBWNxIXLtv7aD1-QQpSQ0vIhEs6rya432chrB9tbdX8a_RH9TThqqVpOHsnPPJoZvUnylpJTziU563a9Z5xxKnLBniXHVDCWEpIXzx_VR8kr73eERDCTL5MjngtZyrw8Tv5MTOjSc9Nq7HsM1o0wa1tVBw-za-WCamA9AhXpVxW29npEHZQzGBRMoXW2h9iPrg5dDfPBbFDDMjjsDPzQyvq9daiVB78_heU8LbjgcNUhhK2Cn2ozaAydNWBb-DZPb28-AZoGvkwu2NlyNVlxiJ4FTnEFi6FHAxfKxQZj6zEo_zp50aL26s39e5L8ms9W00V6-f3z-XRymdacE5YKLrkiTIq8JCVv8qYUJK8pQSaRrBGJqItMNXVBm5ats6LEbF3KLGsKUcoWc36SfLzz7od1H0Fl4oK62ruuRzdWFrvq6Y_pttXGXlWyEPH2JAo-3Auc_T0oH6q-87XSGo2yg69YkcVJOaU8ou__Q3d2iOfWB0qUWUaoPAjTO6p21nun2odhKKkOoaiehCLy7x5v8ED_SwH_C0vXsvU</recordid><startdate>20221124</startdate><enddate>20221124</enddate><creator>Dong, Linsha</creator><creator>Cao, Thao Quyen</creator><creator>Liu, Zhiming</creator><creator>Tuan, Nguyen Quoc</creator><creator>Kim, Youn-Chul</creator><creator>Sohn, Jae Hak</creator><creator>Yim, Joung Han</creator><creator>Lee, Dong-Sung</creator><creator>Oh, Hyuncheol</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9234-7567</orcidid><orcidid>https://orcid.org/0000-0002-9704-1807</orcidid><orcidid>https://orcid.org/0009-0001-6170-5747</orcidid></search><sort><creationdate>20221124</creationdate><title>Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes</title><author>Dong, Linsha ; Cao, Thao Quyen ; Liu, Zhiming ; Tuan, Nguyen Quoc ; Kim, Youn-Chul ; Sohn, Jae Hak ; Yim, Joung Han ; Lee, Dong-Sung ; Oh, Hyuncheol</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3302-4393e029468083d6d8406c10a29a0baa04c75edc71df2b578a5b8955d7489fa63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Atopic dermatitis</topic><topic>Carbon</topic><topic>Cell adhesion</topic><topic>Chemokines</topic><topic>Cytokines</topic><topic>Cytokines - metabolism</topic><topic>Dermatitis, Atopic - metabolism</topic><topic>Eczema</topic><topic>Fungi</topic><topic>Humans</topic><topic>Immune system</topic><topic>Inflammation</topic><topic>Intercellular adhesion molecule 1</topic><topic>Interferon</topic><topic>Interleukin 6</topic><topic>Interleukin 8</topic><topic>Janus kinase 2</topic><topic>Janus Kinase 2 - metabolism</topic><topic>Keratinocytes</topic><topic>Keratinocytes - metabolism</topic><topic>Metabolites</topic><topic>NF-kappa B - metabolism</topic><topic>NF-κB protein</topic><topic>Nuclear transport</topic><topic>Pathogenesis</topic><topic>Pleosporales</topic><topic>Quality of Life</topic><topic>RANTES</topic><topic>Signal transduction</topic><topic>Skin diseases</topic><topic>Stat3 protein</topic><topic>STAT3 Transcription Factor - metabolism</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Tumor necrosis factor-α</topic><topic>γ-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dong, Linsha</creatorcontrib><creatorcontrib>Cao, Thao Quyen</creatorcontrib><creatorcontrib>Liu, Zhiming</creatorcontrib><creatorcontrib>Tuan, Nguyen Quoc</creatorcontrib><creatorcontrib>Kim, Youn-Chul</creatorcontrib><creatorcontrib>Sohn, Jae Hak</creatorcontrib><creatorcontrib>Yim, Joung Han</creatorcontrib><creatorcontrib>Lee, Dong-Sung</creatorcontrib><creatorcontrib>Oh, Hyuncheol</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dong, Linsha</au><au>Cao, Thao Quyen</au><au>Liu, Zhiming</au><au>Tuan, Nguyen Quoc</au><au>Kim, Youn-Chul</au><au>Sohn, Jae Hak</au><au>Yim, Joung Han</au><au>Lee, Dong-Sung</au><au>Oh, Hyuncheol</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2022-11-24</date><risdate>2022</risdate><volume>23</volume><issue>23</issue><spage>14642</spage><pages>14642-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Atopic dermatitis (AD) is a chronic inflammatory skin disease with a profound negative impact on patients' quality of life. Four known secondary fungal metabolites were found in the chemical study of the Antarctic fungus
sp. SF-7343, including 14-methoxyalternate C (
), 5'-methoxy-6-methyl-biphenyl-3,4,3'-triol (
), 3,8,10-trihydroxy-4-methoxy-6-methylbenzocoumarin (
), and alternariol monomethyl ether (
). Additionally, we identified the skin anti-inflammatory composition from the SF-7343 strain. Interleukin-8 and -6 Screening results showed that compound
inhibited IL-8 and IL-6 in tumor necrosis factor-α/interferon-γ stimulated HaCaT cells. Compound
showed inhibitory effects on MDC and RANTES. It also downregulated the expression of intercellular adhesion molecule-1 (ICAM-1) and upregulated the expression of involucrin. The results of the mechanistic study showed that compound
inhibited the nuclear translocation of nuclear factor-kappa B p65 and STAT3. In conclusion, this study demonstrates the potential of the Antarctic fungal strain SF-7343 as a bioactive resource to inhibit skin inflammation, such as AD.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36498968</pmid><doi>10.3390/ijms232314642</doi><orcidid>https://orcid.org/0000-0002-9234-7567</orcidid><orcidid>https://orcid.org/0000-0002-9704-1807</orcidid><orcidid>https://orcid.org/0009-0001-6170-5747</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of molecular sciences, 2022-11, Vol.23 (23), p.14642 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Anti-Inflammatory Agents - therapeutic use Atopic dermatitis Carbon Cell adhesion Chemokines Cytokines Cytokines - metabolism Dermatitis, Atopic - metabolism Eczema Fungi Humans Immune system Inflammation Intercellular adhesion molecule 1 Interferon Interleukin 6 Interleukin 8 Janus kinase 2 Janus Kinase 2 - metabolism Keratinocytes Keratinocytes - metabolism Metabolites NF-kappa B - metabolism NF-κB protein Nuclear transport Pathogenesis Pleosporales Quality of Life RANTES Signal transduction Skin diseases Stat3 protein STAT3 Transcription Factor - metabolism Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α γ-Interferon |
| title | Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain Pleosporales sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes |
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