Himatanthus bracteatus -Composed In Situ Polymerizable Hydrogel for Wound Healing
The Himatanthus genus presents anti-inflammatory, antioxidant activities, suggesting potential wound-healing properties. This study aimed to develop and analyze the wound-healing properties of a photopolymerizable gelatin-based hydrogel (GelMA) containing an ethanolic extract of Himatanthus bracteat...
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| Veröffentlicht in: | International journal of molecular sciences 2022-12, Vol.23 (23), p.15176 |
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| creator | de Almeida, Bernadeth M Dos Santos, Izabella D Dorta de Carvalho, Felipe M A Correa, Luana C Cunha, John L S Dariva, Claudio Severino, Patricia Cardoso, Juliana C Souto, Eliana B de Albuquerque-Júnior, Ricardo L C |
| description | The Himatanthus genus presents anti-inflammatory, antioxidant activities, suggesting potential wound-healing properties. This study aimed to develop and analyze the wound-healing properties of a photopolymerizable gelatin-based hydrogel (GelMA) containing an ethanolic extract of Himatanthus bracteatus in a murine model. The extract was obtained under high pressure conditions, incorporated (2%) into the GelMA (GelMA-HB), and physically characterized. The anti-inflammatory activity of the extract was assessed using a carrageenan-induced pleurisy model and the GelMA-HB scarring properties in a wound-healing assay. The extract reduced IL-1β and TNF-α levels (48.5 ± 6.7 and 64.1 ± 4.9 pg/mL) compared to the vehicle (94.4 ± 2.3 pg/mL and 106.3 ± 5.7 pg/mL; p < 0.001). GelMA-HB depicted significantly lower swelling and increased resistance to mechanical compression compared to GelMA (p < 0.05). GelMA-HB accelerated wound closure over the time course of the experiment (p < 0.05) and promoted a significantly greater peak of myofibroblast differentiation (36.1 ± 6.6 cells) and microvascular density (23.1 ± 0.7 microvessels) on day 7 in comparison to GelMA (31.9 ± 5.3 cells and 20.2 ± 0.6 microvessels) and the control (25.8 ± 4.6 cells and 17.5 ± 0.5 microvessels) (p < 0.05). In conclusion, GelMA-HB improved wound healing in rodents, probably by modulating the inflammatory response and myofibroblastic and microvascular differentiation. |
| doi_str_mv | 10.3390/ijms232315176 |
| format | Article |
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This study aimed to develop and analyze the wound-healing properties of a photopolymerizable gelatin-based hydrogel (GelMA) containing an ethanolic extract of Himatanthus bracteatus in a murine model. The extract was obtained under high pressure conditions, incorporated (2%) into the GelMA (GelMA-HB), and physically characterized. The anti-inflammatory activity of the extract was assessed using a carrageenan-induced pleurisy model and the GelMA-HB scarring properties in a wound-healing assay. The extract reduced IL-1β and TNF-α levels (48.5 ± 6.7 and 64.1 ± 4.9 pg/mL) compared to the vehicle (94.4 ± 2.3 pg/mL and 106.3 ± 5.7 pg/mL; p < 0.001). GelMA-HB depicted significantly lower swelling and increased resistance to mechanical compression compared to GelMA (p < 0.05). GelMA-HB accelerated wound closure over the time course of the experiment (p < 0.05) and promoted a significantly greater peak of myofibroblast differentiation (36.1 ± 6.6 cells) and microvascular density (23.1 ± 0.7 microvessels) on day 7 in comparison to GelMA (31.9 ± 5.3 cells and 20.2 ± 0.6 microvessels) and the control (25.8 ± 4.6 cells and 17.5 ± 0.5 microvessels) (p < 0.05). In conclusion, GelMA-HB improved wound healing in rodents, probably by modulating the inflammatory response and myofibroblastic and microvascular differentiation.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms232315176</identifier><identifier>PMID: 36499503</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Angiogenesis ; Animal models ; Animals ; Anti-inflammatory agents ; Apocynaceae ; Blood vessels ; Carrageenan ; Cell differentiation ; Compression ; Connective tissue ; Differentiation ; Gelatin ; Gelatin - pharmacology ; Growth factors ; Hydrogels ; Hydrogels - pharmacology ; IL-1β ; Inflammation ; Inflammatory response ; Methacrylates - pharmacology ; Mice ; Microvasculature ; Natural products ; Phytochemicals ; Pleurisy ; Tumor necrosis factor-α ; Wound Healing</subject><ispartof>International journal of molecular sciences, 2022-12, Vol.23 (23), p.15176</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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This study aimed to develop and analyze the wound-healing properties of a photopolymerizable gelatin-based hydrogel (GelMA) containing an ethanolic extract of Himatanthus bracteatus in a murine model. The extract was obtained under high pressure conditions, incorporated (2%) into the GelMA (GelMA-HB), and physically characterized. The anti-inflammatory activity of the extract was assessed using a carrageenan-induced pleurisy model and the GelMA-HB scarring properties in a wound-healing assay. The extract reduced IL-1β and TNF-α levels (48.5 ± 6.7 and 64.1 ± 4.9 pg/mL) compared to the vehicle (94.4 ± 2.3 pg/mL and 106.3 ± 5.7 pg/mL; p < 0.001). GelMA-HB depicted significantly lower swelling and increased resistance to mechanical compression compared to GelMA (p < 0.05). GelMA-HB accelerated wound closure over the time course of the experiment (p < 0.05) and promoted a significantly greater peak of myofibroblast differentiation (36.1 ± 6.6 cells) and microvascular density (23.1 ± 0.7 microvessels) on day 7 in comparison to GelMA (31.9 ± 5.3 cells and 20.2 ± 0.6 microvessels) and the control (25.8 ± 4.6 cells and 17.5 ± 0.5 microvessels) (p < 0.05). In conclusion, GelMA-HB improved wound healing in rodents, probably by modulating the inflammatory response and myofibroblastic and microvascular differentiation.</description><subject>Angiogenesis</subject><subject>Animal models</subject><subject>Animals</subject><subject>Anti-inflammatory agents</subject><subject>Apocynaceae</subject><subject>Blood vessels</subject><subject>Carrageenan</subject><subject>Cell differentiation</subject><subject>Compression</subject><subject>Connective tissue</subject><subject>Differentiation</subject><subject>Gelatin</subject><subject>Gelatin - pharmacology</subject><subject>Growth factors</subject><subject>Hydrogels</subject><subject>Hydrogels - pharmacology</subject><subject>IL-1β</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Methacrylates - pharmacology</subject><subject>Mice</subject><subject>Microvasculature</subject><subject>Natural products</subject><subject>Phytochemicals</subject><subject>Pleurisy</subject><subject>Tumor necrosis factor-α</subject><subject>Wound Healing</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkU1r20AQhpfSkDhujr0WQS-9KNnV7Id1KRTTxoZAEtKQ47K7GtkyktbdlQLur--GOCbuaQbm4WUeXkI-M3oJUNKrZtPFAgpggin5gUwYL4qcUqk-vtvPyHmMG0oTKMpTcgaSl6WgMCH3i6Yzg-mH9RgzG4wb0Axpzee-2_qIVbbss4dmGLM73-46DM1fY1vMFrsq-BW2We1D9uTHvsoWaNqmX30iJ7VpI17s55Q8_vr5e77Ib26vl_MfN7njTAy5ZA6tUmpWSSGhmikAwWacIpMFRQQrrQFZcMedxdqho7VgaEVdMgTBLUzJ99fc7Wg7rBz2QzCt3oYkFHbam0YfX_pmrVf-WZcKSqVYCvi2Dwj-z4hx0F0THbat6dGPURdKANCSU5rQr_-hGz-GPuklis-EoCwJTEn-SrngYwxYH55hVL-UpY_KSvyX9wYH-q0d-AcXlpDt</recordid><startdate>20221202</startdate><enddate>20221202</enddate><creator>de Almeida, Bernadeth M</creator><creator>Dos Santos, Izabella D Dorta</creator><creator>de Carvalho, Felipe M A</creator><creator>Correa, Luana C</creator><creator>Cunha, John L S</creator><creator>Dariva, Claudio</creator><creator>Severino, Patricia</creator><creator>Cardoso, Juliana C</creator><creator>Souto, Eliana B</creator><creator>de Albuquerque-Júnior, Ricardo L C</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4444-7632</orcidid><orcidid>https://orcid.org/0000-0001-6527-6612</orcidid><orcidid>https://orcid.org/0000-0002-0357-4144</orcidid><orcidid>https://orcid.org/0000-0002-9737-6017</orcidid><orcidid>https://orcid.org/0000-0002-0679-8485</orcidid></search><sort><creationdate>20221202</creationdate><title>Himatanthus bracteatus -Composed In Situ Polymerizable Hydrogel for Wound Healing</title><author>de Almeida, Bernadeth M ; 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This study aimed to develop and analyze the wound-healing properties of a photopolymerizable gelatin-based hydrogel (GelMA) containing an ethanolic extract of Himatanthus bracteatus in a murine model. The extract was obtained under high pressure conditions, incorporated (2%) into the GelMA (GelMA-HB), and physically characterized. The anti-inflammatory activity of the extract was assessed using a carrageenan-induced pleurisy model and the GelMA-HB scarring properties in a wound-healing assay. The extract reduced IL-1β and TNF-α levels (48.5 ± 6.7 and 64.1 ± 4.9 pg/mL) compared to the vehicle (94.4 ± 2.3 pg/mL and 106.3 ± 5.7 pg/mL; p < 0.001). GelMA-HB depicted significantly lower swelling and increased resistance to mechanical compression compared to GelMA (p < 0.05). GelMA-HB accelerated wound closure over the time course of the experiment (p < 0.05) and promoted a significantly greater peak of myofibroblast differentiation (36.1 ± 6.6 cells) and microvascular density (23.1 ± 0.7 microvessels) on day 7 in comparison to GelMA (31.9 ± 5.3 cells and 20.2 ± 0.6 microvessels) and the control (25.8 ± 4.6 cells and 17.5 ± 0.5 microvessels) (p < 0.05). In conclusion, GelMA-HB improved wound healing in rodents, probably by modulating the inflammatory response and myofibroblastic and microvascular differentiation.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36499503</pmid><doi>10.3390/ijms232315176</doi><orcidid>https://orcid.org/0000-0003-4444-7632</orcidid><orcidid>https://orcid.org/0000-0001-6527-6612</orcidid><orcidid>https://orcid.org/0000-0002-0357-4144</orcidid><orcidid>https://orcid.org/0000-0002-9737-6017</orcidid><orcidid>https://orcid.org/0000-0002-0679-8485</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Angiogenesis Animal models Animals Anti-inflammatory agents Apocynaceae Blood vessels Carrageenan Cell differentiation Compression Connective tissue Differentiation Gelatin Gelatin - pharmacology Growth factors Hydrogels Hydrogels - pharmacology IL-1β Inflammation Inflammatory response Methacrylates - pharmacology Mice Microvasculature Natural products Phytochemicals Pleurisy Tumor necrosis factor-α Wound Healing |
| title | Himatanthus bracteatus -Composed In Situ Polymerizable Hydrogel for Wound Healing |
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