Efficacy, Safety, and Challenges of CAR T-Cells in the Treatment of Solid Tumors

Immunotherapy has been the fifth pillar of cancer treatment in the past decade. Chimeric antigen receptor (CAR) T-cell therapy is a newly designed adoptive immunotherapy that is able to target and further eliminate cancer cells by engaging with MHC-independent tumor-antigens. CAR T-cell therapy has...

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Veröffentlicht in:	Cancers 2022-12, Vol.14 (23), p.5983
Hauptverfasser:	Chen, Qiuqiang, Lu, Lingeng, Ma, Wenxue
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive immunotherapy Antigen (tumor-associated) Cancer Cancer therapies Care and treatment Cell therapy Chimeric antigen receptors Cytokines FDA approval Immunotherapy Life span Lymphocytes Lymphocytes T Major histocompatibility complex Malignancy Neurotoxicity Patient outcomes Review Safety Solid tumors Tumors
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