Acute Stress Induces Different Changes on the Expression of BDNF and trkB in the Mesocorticolimbic System of Two Lines of Rats Differing in Their Response to Stressors
The present work was undertaken to investigate the effects of acute forced swimming (FS) on the levels of brain-derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (trkB) proteins in: the ventral tegmental area (VTA); the nucleus accumbens (Acb) shell and core compartments; and the ant...
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| Veröffentlicht in: | International journal of molecular sciences 2022-11, Vol.23 (23), p.14995 |
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| creator | Serra, Maria Pina Sanna, Francesco Boi, Marianna Poddighe, Laura Secci, Lorenzo Trucas, Marcello Fernández-Teruel, Alberto Corda, Maria Giuseppa Giorgi, Osvaldo Quartu, Marina |
| description | The present work was undertaken to investigate the effects of acute forced swimming (FS) on the levels of brain-derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (trkB) proteins in: the ventral tegmental area (VTA); the nucleus accumbens (Acb) shell and core compartments; and the anterior cingulate (ACg), prelimbic (PL) and infralimbic (IL) territories of the prefrontal cortex of genetic models of vulnerability (RLA, Roman low-avoidance rats) and resistance (RHA, Roman high-avoidance rats) to stress-induced depression. We report for the first time that FS induced very rapid and distinct changes in the levels of BDNF and trkB proteins in different areas of the mesocorticolimbic system of RHA and RLA rats. Thus, (1) in the VTA and Acb core, FS elicited a significant increase of both BDNF- and trkB-LI in RHA but not RLA rats, whereas in the Acb shell no significant changes in BDNF- and trkB-LI across the line and treatment were observed; (2) in RLA rats, the basal levels of BDNF-LI in the IL/PL cortex and of trkB-LI in the ACg cortex were markedly lower than those of RHA rats; moreover, BDNF- and trkB-LI in the IL/PL and ACg cortex were increased by FS in RLA rats but decreased in their RHA counterparts. These results provide compelling evidence that the genetic background influences the effects of stress on BDNF/trkB signaling and support the view that the same stressor may impact differently on the expression of BDNF in discrete brain areas. |
| doi_str_mv | 10.3390/ijms232314995 |
| format | Article |
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We report for the first time that FS induced very rapid and distinct changes in the levels of BDNF and trkB proteins in different areas of the mesocorticolimbic system of RHA and RLA rats. Thus, (1) in the VTA and Acb core, FS elicited a significant increase of both BDNF- and trkB-LI in RHA but not RLA rats, whereas in the Acb shell no significant changes in BDNF- and trkB-LI across the line and treatment were observed; (2) in RLA rats, the basal levels of BDNF-LI in the IL/PL cortex and of trkB-LI in the ACg cortex were markedly lower than those of RHA rats; moreover, BDNF- and trkB-LI in the IL/PL and ACg cortex were increased by FS in RLA rats but decreased in their RHA counterparts. These results provide compelling evidence that the genetic background influences the effects of stress on BDNF/trkB signaling and support the view that the same stressor may impact differently on the expression of BDNF in discrete brain areas.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms232314995</identifier><identifier>PMID: 36499323</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Antidepressants ; Avoidance ; Behavior ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - metabolism ; Cerebral Cortex - metabolism ; Hypotheses ; Kinases ; Mental depression ; Nucleus accumbens ; Nucleus Accumbens - metabolism ; Prefrontal cortex ; Prefrontal Cortex - metabolism ; Protein-tyrosine kinase receptors ; Proteins ; Rats ; Receptor, trkB - genetics ; Receptor, trkB - metabolism ; Statistical analysis ; TrkB receptors ; Tyrosine ; Ventral Tegmental Area - metabolism ; Ventral tegmentum</subject><ispartof>International journal of molecular sciences, 2022-11, Vol.23 (23), p.14995</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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These results provide compelling evidence that the genetic background influences the effects of stress on BDNF/trkB signaling and support the view that the same stressor may impact differently on the expression of BDNF in discrete brain areas.</description><subject>Animals</subject><subject>Antidepressants</subject><subject>Avoidance</subject><subject>Behavior</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>Cerebral Cortex - metabolism</subject><subject>Hypotheses</subject><subject>Kinases</subject><subject>Mental depression</subject><subject>Nucleus accumbens</subject><subject>Nucleus Accumbens - metabolism</subject><subject>Prefrontal cortex</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Protein-tyrosine kinase receptors</subject><subject>Proteins</subject><subject>Rats</subject><subject>Receptor, trkB - genetics</subject><subject>Receptor, trkB - metabolism</subject><subject>Statistical analysis</subject><subject>TrkB receptors</subject><subject>Tyrosine</subject><subject>Ventral Tegmental Area - 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We report for the first time that FS induced very rapid and distinct changes in the levels of BDNF and trkB proteins in different areas of the mesocorticolimbic system of RHA and RLA rats. Thus, (1) in the VTA and Acb core, FS elicited a significant increase of both BDNF- and trkB-LI in RHA but not RLA rats, whereas in the Acb shell no significant changes in BDNF- and trkB-LI across the line and treatment were observed; (2) in RLA rats, the basal levels of BDNF-LI in the IL/PL cortex and of trkB-LI in the ACg cortex were markedly lower than those of RHA rats; moreover, BDNF- and trkB-LI in the IL/PL and ACg cortex were increased by FS in RLA rats but decreased in their RHA counterparts. 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| ispartof | International journal of molecular sciences, 2022-11, Vol.23 (23), p.14995 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Antidepressants Avoidance Behavior Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Cerebral Cortex - metabolism Hypotheses Kinases Mental depression Nucleus accumbens Nucleus Accumbens - metabolism Prefrontal cortex Prefrontal Cortex - metabolism Protein-tyrosine kinase receptors Proteins Rats Receptor, trkB - genetics Receptor, trkB - metabolism Statistical analysis TrkB receptors Tyrosine Ventral Tegmental Area - metabolism Ventral tegmentum |
| title | Acute Stress Induces Different Changes on the Expression of BDNF and trkB in the Mesocorticolimbic System of Two Lines of Rats Differing in Their Response to Stressors |
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