Therapeutic Potential of Extracellular Vesicles in Aging and Age-Related Diseases
Aging is associated with an alteration of intercellular communication. These changes in the extracellular environment contribute to the aging phenotype and have been linked to different aging-related diseases. Extracellular vesicles (EVs) are factors that mediate the transmission of signaling molecu...
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| Veröffentlicht in: | International journal of molecular sciences 2022-11, Vol.23 (23), p.14632 |
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| creator | Sanz-Ros, Jorge Mas-Bargues, Cristina Romero-García, Nekane Huete-Acevedo, Javier Dromant, Mar Borrás, Consuelo |
| description | Aging is associated with an alteration of intercellular communication. These changes in the extracellular environment contribute to the aging phenotype and have been linked to different aging-related diseases. Extracellular vesicles (EVs) are factors that mediate the transmission of signaling molecules between cells. In the aging field, these EVs have been shown to regulate important aging processes, such as oxidative stress or senescence, both in vivo and in vitro. EVs from healthy cells, particularly those coming from stem cells (SCs), have been described as potential effectors of the regenerative potential of SCs. Many studies with different animal models have shown promising results in the field of regenerative medicine. EVs are now viewed as a potential cell-free therapy for tissue damage and several diseases. Here we propose EVs as regulators of the aging process, with an important role in tissue regeneration and a raising therapy for age-related diseases. |
| doi_str_mv | 10.3390/ijms232314632 |
| format | Article |
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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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| subjects | Age Aging Animal models Animals Autophagy Biosynthesis Cell Communication - physiology Cell cycle DNA damage Extracellular Vesicles Inflammation Lipids Metabolism Oxidative stress Phenotypes Physiology Proteins Regeneration (physiology) Regenerative Medicine Review Senescence Stem cell transplantation Stem Cells Telomerase Tissue engineering Vesicles |
| title | Therapeutic Potential of Extracellular Vesicles in Aging and Age-Related Diseases |
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