Therapeutic Efficacy of Shexiang Baoxin Pill Combined with Exercise in Patients with Heart Failure with Preserved Ejection Fraction: A Single-Center, Double-Blind, Randomized Controlled Trial
Objective To evaluate the therapeutic efficacy of Shexiang Baoxin Pill combined with exercise in heart failure patients with preserved ejection fraction (HFpEF). Methods Sixty patients with HFpEF were randomly divided into group A ( n =20), receiving Shexiang Baoxin Pill combined with home-based exe...
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| Veröffentlicht in: | Chinese journal of integrative medicine 2023-02, Vol.29 (2), p.99-107 |
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| container_title | Chinese journal of integrative medicine |
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| creator | Liu, Si-pei Zhou, Jian-guan Jin, Yan Guo, Yan Zhou, Shi-wei Lin, Mei-lan Zhang, Jun Wang, Xiao-nv Guan, Xia-fei Wang, Lei |
| description | Objective
To evaluate the therapeutic efficacy of Shexiang Baoxin Pill combined with exercise in heart failure patients with preserved ejection fraction (HFpEF).
Methods
Sixty patients with HFpEF were randomly divided into group A (
n
=20), receiving Shexiang Baoxin Pill combined with home-based exercise training based on conventional drugs for 12 weeks; group B (
n
=20), receiving conventional drugs combined with home-based exercise training for 12 weeks; and group C (
n
=20), receiving conventional drug treatment only. Peak oxygen uptake (peakVO
2
), anaerobic threshold (AT), 6-min walking test (6MWT), Pittsburgh Sleep Quality Index (PSQI), and SF-36 questionnaire (SF-36) results before and after treatment were compared among groups.
Results
After the 12-week intervention, patients in group C showed significant declines in peakVO
2
, AT, 6MWT, PSQI, and SF-36 compared with pre-treatment (
P |
| doi_str_mv | 10.1007/s11655-022-3627-3 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9734389</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>36484921</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-4dbcb79eb30a8c69ece6cabb86f88b95a2d3fc454ba87a3f8bcb3f0426a6eab3</originalsourceid><addsrcrecordid>eNp9Uctu1DAUjRCIPuAD2CB_QFMc23mxQGrDDEWqREVnb107NzMeeeyRnZQpP8ev4SFQwYaVj30evrony94U9LKgtH4Xi6Iqy5wylvOK1Tl_lp0WbctzKih7nnBVs4SL8iQ7i3FLaVlXtHyZnfBKNKJlxWn2Y7XBAHucRqPJYhiMBv1I_EDuN3gw4NbkGvzBOHJnrCWd3ynjsCffzLghiwMGbSKSIw2jQTfGmblBCCNZgrFTwPnpLmDE8JC8iy3q0XhHlgF-gffkitwbt7aYdykDwwX56CeVrtfWuP6CfAXX-535nsydd2Pw1ia4Cgbsq-zFADbi69_nebZaLlbdTX775dPn7uo210KwMRe90qpuUXEKja5a1FhpUKqphqZRbQms54MWpVDQ1MCHJsn5QAWroEJQ_Dz7MMfuJ7XDXqcxA1i5D2YH4VF6MPJfxpmNXPsH2dZc8KZNAcUcoIOPMeDw5C2oPJYp5zJlKlMey5Q8ed7-_emT4097ScBmQUyUW2OQWz8Fl_bwn9SfGYWwtw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Therapeutic Efficacy of Shexiang Baoxin Pill Combined with Exercise in Patients with Heart Failure with Preserved Ejection Fraction: A Single-Center, Double-Blind, Randomized Controlled Trial</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>SpringerLink Journals - AutoHoldings</source><creator>Liu, Si-pei ; Zhou, Jian-guan ; Jin, Yan ; Guo, Yan ; Zhou, Shi-wei ; Lin, Mei-lan ; Zhang, Jun ; Wang, Xiao-nv ; Guan, Xia-fei ; Wang, Lei</creator><creatorcontrib>Liu, Si-pei ; Zhou, Jian-guan ; Jin, Yan ; Guo, Yan ; Zhou, Shi-wei ; Lin, Mei-lan ; Zhang, Jun ; Wang, Xiao-nv ; Guan, Xia-fei ; Wang, Lei</creatorcontrib><description>Objective
To evaluate the therapeutic efficacy of Shexiang Baoxin Pill combined with exercise in heart failure patients with preserved ejection fraction (HFpEF).
Methods
Sixty patients with HFpEF were randomly divided into group A (
n
=20), receiving Shexiang Baoxin Pill combined with home-based exercise training based on conventional drugs for 12 weeks; group B (
n
=20), receiving conventional drugs combined with home-based exercise training for 12 weeks; and group C (
n
=20), receiving conventional drug treatment only. Peak oxygen uptake (peakVO
2
), anaerobic threshold (AT), 6-min walking test (6MWT), Pittsburgh Sleep Quality Index (PSQI), and SF-36 questionnaire (SF-36) results before and after treatment were compared among groups.
Results
After the 12-week intervention, patients in group C showed significant declines in peakVO
2
, AT, 6MWT, PSQI, and SF-36 compared with pre-treatment (
P
<0.01), while groups A and B both showed significant improvements in peakVO
2
, AT, 6MWT, PSQI, and SF-36 results compared with pre-treatment (
P
<0.01). Compared with group C, patients in groups A and B showed significant improvements in peakVO
2
, AT, 6MWT, PSQI, and SF-36 (
P
<0.01). In addition, patients in group A showed more significant improvements in physical function, role-physical, vitality, and mental health scores on the SF-36 questionnaire, and PSQI scores than those in group B (
P
<0.01).
Conclusions
Exercise training improved exercise tolerance, sleep quality and quality of life (QoL) in patients with HFpEF. Notably, Shexiang Baoxin Pill played an active role in sleep quality and QoL of patients with HFpEF. (The trial was registered in the Chinese Clinical Trial Registry (No. ChiCTR2100054322))</description><identifier>ISSN: 1672-0415</identifier><identifier>EISSN: 1993-0402</identifier><identifier>DOI: 10.1007/s11655-022-3627-3</identifier><identifier>PMID: 36484921</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Exercise ; Heart Failure - therapy ; Humans ; Medicine ; Medicine & Public Health ; Original ; Original Article ; Quality of Life ; Stroke Volume</subject><ispartof>Chinese journal of integrative medicine, 2023-02, Vol.29 (2), p.99-107</ispartof><rights>The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-4dbcb79eb30a8c69ece6cabb86f88b95a2d3fc454ba87a3f8bcb3f0426a6eab3</citedby><cites>FETCH-LOGICAL-c442t-4dbcb79eb30a8c69ece6cabb86f88b95a2d3fc454ba87a3f8bcb3f0426a6eab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11655-022-3627-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11655-022-3627-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36484921$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Si-pei</creatorcontrib><creatorcontrib>Zhou, Jian-guan</creatorcontrib><creatorcontrib>Jin, Yan</creatorcontrib><creatorcontrib>Guo, Yan</creatorcontrib><creatorcontrib>Zhou, Shi-wei</creatorcontrib><creatorcontrib>Lin, Mei-lan</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Wang, Xiao-nv</creatorcontrib><creatorcontrib>Guan, Xia-fei</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><title>Therapeutic Efficacy of Shexiang Baoxin Pill Combined with Exercise in Patients with Heart Failure with Preserved Ejection Fraction: A Single-Center, Double-Blind, Randomized Controlled Trial</title><title>Chinese journal of integrative medicine</title><addtitle>Chin. J. Integr. Med</addtitle><addtitle>Chin J Integr Med</addtitle><description>Objective
To evaluate the therapeutic efficacy of Shexiang Baoxin Pill combined with exercise in heart failure patients with preserved ejection fraction (HFpEF).
Methods
Sixty patients with HFpEF were randomly divided into group A (
n
=20), receiving Shexiang Baoxin Pill combined with home-based exercise training based on conventional drugs for 12 weeks; group B (
n
=20), receiving conventional drugs combined with home-based exercise training for 12 weeks; and group C (
n
=20), receiving conventional drug treatment only. Peak oxygen uptake (peakVO
2
), anaerobic threshold (AT), 6-min walking test (6MWT), Pittsburgh Sleep Quality Index (PSQI), and SF-36 questionnaire (SF-36) results before and after treatment were compared among groups.
Results
After the 12-week intervention, patients in group C showed significant declines in peakVO
2
, AT, 6MWT, PSQI, and SF-36 compared with pre-treatment (
P
<0.01), while groups A and B both showed significant improvements in peakVO
2
, AT, 6MWT, PSQI, and SF-36 results compared with pre-treatment (
P
<0.01). Compared with group C, patients in groups A and B showed significant improvements in peakVO
2
, AT, 6MWT, PSQI, and SF-36 (
P
<0.01). In addition, patients in group A showed more significant improvements in physical function, role-physical, vitality, and mental health scores on the SF-36 questionnaire, and PSQI scores than those in group B (
P
<0.01).
Conclusions
Exercise training improved exercise tolerance, sleep quality and quality of life (QoL) in patients with HFpEF. Notably, Shexiang Baoxin Pill played an active role in sleep quality and QoL of patients with HFpEF. (The trial was registered in the Chinese Clinical Trial Registry (No. ChiCTR2100054322))</description><subject>Exercise</subject><subject>Heart Failure - therapy</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original</subject><subject>Original Article</subject><subject>Quality of Life</subject><subject>Stroke Volume</subject><issn>1672-0415</issn><issn>1993-0402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uctu1DAUjRCIPuAD2CB_QFMc23mxQGrDDEWqREVnb107NzMeeeyRnZQpP8ev4SFQwYaVj30evrony94U9LKgtH4Xi6Iqy5wylvOK1Tl_lp0WbctzKih7nnBVs4SL8iQ7i3FLaVlXtHyZnfBKNKJlxWn2Y7XBAHucRqPJYhiMBv1I_EDuN3gw4NbkGvzBOHJnrCWd3ynjsCffzLghiwMGbSKSIw2jQTfGmblBCCNZgrFTwPnpLmDE8JC8iy3q0XhHlgF-gffkitwbt7aYdykDwwX56CeVrtfWuP6CfAXX-535nsydd2Pw1ia4Cgbsq-zFADbi69_nebZaLlbdTX775dPn7uo210KwMRe90qpuUXEKja5a1FhpUKqphqZRbQms54MWpVDQ1MCHJsn5QAWroEJQ_Dz7MMfuJ7XDXqcxA1i5D2YH4VF6MPJfxpmNXPsH2dZc8KZNAcUcoIOPMeDw5C2oPJYp5zJlKlMey5Q8ed7-_emT4097ScBmQUyUW2OQWz8Fl_bwn9SfGYWwtw</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Liu, Si-pei</creator><creator>Zhou, Jian-guan</creator><creator>Jin, Yan</creator><creator>Guo, Yan</creator><creator>Zhou, Shi-wei</creator><creator>Lin, Mei-lan</creator><creator>Zhang, Jun</creator><creator>Wang, Xiao-nv</creator><creator>Guan, Xia-fei</creator><creator>Wang, Lei</creator><general>Springer Nature Singapore</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20230201</creationdate><title>Therapeutic Efficacy of Shexiang Baoxin Pill Combined with Exercise in Patients with Heart Failure with Preserved Ejection Fraction: A Single-Center, Double-Blind, Randomized Controlled Trial</title><author>Liu, Si-pei ; Zhou, Jian-guan ; Jin, Yan ; Guo, Yan ; Zhou, Shi-wei ; Lin, Mei-lan ; Zhang, Jun ; Wang, Xiao-nv ; Guan, Xia-fei ; Wang, Lei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-4dbcb79eb30a8c69ece6cabb86f88b95a2d3fc454ba87a3f8bcb3f0426a6eab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Exercise</topic><topic>Heart Failure - therapy</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original</topic><topic>Original Article</topic><topic>Quality of Life</topic><topic>Stroke Volume</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Si-pei</creatorcontrib><creatorcontrib>Zhou, Jian-guan</creatorcontrib><creatorcontrib>Jin, Yan</creatorcontrib><creatorcontrib>Guo, Yan</creatorcontrib><creatorcontrib>Zhou, Shi-wei</creatorcontrib><creatorcontrib>Lin, Mei-lan</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Wang, Xiao-nv</creatorcontrib><creatorcontrib>Guan, Xia-fei</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Chinese journal of integrative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Si-pei</au><au>Zhou, Jian-guan</au><au>Jin, Yan</au><au>Guo, Yan</au><au>Zhou, Shi-wei</au><au>Lin, Mei-lan</au><au>Zhang, Jun</au><au>Wang, Xiao-nv</au><au>Guan, Xia-fei</au><au>Wang, Lei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic Efficacy of Shexiang Baoxin Pill Combined with Exercise in Patients with Heart Failure with Preserved Ejection Fraction: A Single-Center, Double-Blind, Randomized Controlled Trial</atitle><jtitle>Chinese journal of integrative medicine</jtitle><stitle>Chin. J. Integr. Med</stitle><addtitle>Chin J Integr Med</addtitle><date>2023-02-01</date><risdate>2023</risdate><volume>29</volume><issue>2</issue><spage>99</spage><epage>107</epage><pages>99-107</pages><issn>1672-0415</issn><eissn>1993-0402</eissn><abstract>Objective
To evaluate the therapeutic efficacy of Shexiang Baoxin Pill combined with exercise in heart failure patients with preserved ejection fraction (HFpEF).
Methods
Sixty patients with HFpEF were randomly divided into group A (
n
=20), receiving Shexiang Baoxin Pill combined with home-based exercise training based on conventional drugs for 12 weeks; group B (
n
=20), receiving conventional drugs combined with home-based exercise training for 12 weeks; and group C (
n
=20), receiving conventional drug treatment only. Peak oxygen uptake (peakVO
2
), anaerobic threshold (AT), 6-min walking test (6MWT), Pittsburgh Sleep Quality Index (PSQI), and SF-36 questionnaire (SF-36) results before and after treatment were compared among groups.
Results
After the 12-week intervention, patients in group C showed significant declines in peakVO
2
, AT, 6MWT, PSQI, and SF-36 compared with pre-treatment (
P
<0.01), while groups A and B both showed significant improvements in peakVO
2
, AT, 6MWT, PSQI, and SF-36 results compared with pre-treatment (
P
<0.01). Compared with group C, patients in groups A and B showed significant improvements in peakVO
2
, AT, 6MWT, PSQI, and SF-36 (
P
<0.01). In addition, patients in group A showed more significant improvements in physical function, role-physical, vitality, and mental health scores on the SF-36 questionnaire, and PSQI scores than those in group B (
P
<0.01).
Conclusions
Exercise training improved exercise tolerance, sleep quality and quality of life (QoL) in patients with HFpEF. Notably, Shexiang Baoxin Pill played an active role in sleep quality and QoL of patients with HFpEF. (The trial was registered in the Chinese Clinical Trial Registry (No. ChiCTR2100054322))</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>36484921</pmid><doi>10.1007/s11655-022-3627-3</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1672-0415 |
| ispartof | Chinese journal of integrative medicine, 2023-02, Vol.29 (2), p.99-107 |
| issn | 1672-0415 1993-0402 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9734389 |
| source | MEDLINE; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | Exercise Heart Failure - therapy Humans Medicine Medicine & Public Health Original Original Article Quality of Life Stroke Volume |
| title | Therapeutic Efficacy of Shexiang Baoxin Pill Combined with Exercise in Patients with Heart Failure with Preserved Ejection Fraction: A Single-Center, Double-Blind, Randomized Controlled Trial |
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