Identification of a novel GR-ARID1a-P53BP1 protein complex involved in DNA damage repair and cell cycle regulation

ARID1a (BAF250), a component of human SWI/SNF chromatin remodeling complexes, is frequently mutated across numerous cancers, and its loss of function has been putatively linked to glucocorticoid resistance. Here, we interrogate the impact of siRNA knockdown of ARID1a compared to a functional interfe...

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Veröffentlicht in:	Oncogene 2022-12, Vol.41 (50), p.5347-5360
Hauptverfasser:	Stubbs, Felicity E., Flynn, Benjamin P., Rivers, Caroline A., Birnie, Matthew T., Herman, Andrew, Swinstead, Erin E., Baek, Songjoon, Fang, Hai, Temple, Jillian, Carroll, Jason S., Hager, Gordon L., Lightman, Stafford L., Conway-Campbell, Becky L.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 38/39 38/89 631/67/395 631/80/83 692/53/2423 82/58 96/106 96/109 96/31 96/95 Apoptosis Cell Biology Cell Cycle Cell Cycle Checkpoints Cell Line, Tumor Cervical cancer Cervix Chromatin - genetics Chromatin remodeling Dexamethasone DNA Damage DNA Repair DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epigenetics Gene expression Genomes Glucocorticoids Glutamine Histone acetyltransferase Histone Acetyltransferases - metabolism Human Genetics Humans Internal Medicine Liquid chromatography Mass spectroscopy Medicine Medicine & Public Health Mismatch repair MSH6 protein Nuclear Proteins - metabolism Oncology p53 Protein Poly(ADP-ribose) Poly(ADP-ribose) polymerase Proteins Receptors, Glucocorticoid - metabolism Ribose siRNA Splicing factors Transcription Factors - genetics Tumor Suppressor p53-Binding Protein 1 - metabolism
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