Unraveling the epigenomic and transcriptomic interplay during alcohol-induced anxiolysis

Positive effects of alcohol drinking such as anxiolysis and euphoria appear to be a crucial factor in the initiation and maintenance of alcohol use disorder (AUD). However, the mechanisms that lead from chromatin reorganization to transcriptomic changes after acute ethanol exposure remain unknown. H...

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Veröffentlicht in:	Molecular psychiatry 2022-11, Vol.27 (11), p.4624-4632
Hauptverfasser:	Krishnan, Harish R., Zhang, Huaibo, Chen, Ying, Bohnsack, John Peyton, Shieh, Annie W., Kusumo, Handojo, Drnevich, Jenny, Liu, Chunyu, Grayson, Dennis R., Maienschein-Cline, Mark, Pandey, Subhash C.
Format:	Artikel
Sprache:	eng
Schlagworte:	101/47 38 38/23 38/39 38/77 38/90 38/91 42/41 631/378 692/699/476/5 Acetylation Alcohol Alcohol use Alcoholism - genetics Amygdala Animal models Animals Behavioral Sciences Biological Psychology Chromatin DNA methylation Drinking behavior Drug abuse Epigenesis, Genetic - genetics Epigenetics Ethanol Ethanol - pharmacology Gene Expression Profiling Histones Hypoxia-inducible factors Medicine Medicine & Public Health Neurosciences Next-generation sequencing Pharmacotherapy Psychiatry Rats RNA, Messenger - metabolism Transcription Factors - genetics Transcriptomics Transposase
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