Mediterranean G6PD variant mitigates expression of DNA methyltransferases and right heart pressure in experimental model of pulmonary hypertension

DNA methylation potentially contributes to the pathogenesis of pulmonary hypertension (PH). However, the role of DNA methyltransferases (DNMTs: 1, 3a, and 3b), the epigenetic writers, in modulating DNA methylation observed in PH remains elusive. Our objective was to determine DNMT activity and expre...

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Veröffentlicht in:	The Journal of biological chemistry 2022-12, Vol.298 (12), p.102691-102691, Article 102691
Hauptverfasser:	Jacob, Christina, Kitagawa, Atsushi, Signoretti, Christina, Dzieciatkowska, Monika, D’Alessandro, Angelo, Gupte, Aaditya, Hossain, Shakib, D’Addario, Catherine A., Gupte, Rakhee, Gupte, Sachin A.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylation Animals Cell Hypoxia Disease Models, Animal DNA DNA Methylation DNA Modification Methylases - metabolism epigenetics experimental Gene Expression Regulation, Enzymologic - genetics Glucosephosphate Dehydrogenase - genetics Glucosephosphate Dehydrogenase - metabolism histone Hypertension, Pulmonary - genetics hypoxia methylation methyltransferases normoxia Oxygen pulmonary arterial hypertension Rats Sugen5416 VEGF blocker
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