The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations

Aims/hypothesis We examined the contribution of rare HNF1A variants to type 2 diabetes risk and age of diagnosis, and the extent to which their impact is affected by overall genetic susceptibility, across three ancestry groups. Methods Using exome sequencing data of 160,615 individuals of the UK Bio...

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Veröffentlicht in:	Diabetologia 2023-01, Vol.66 (1), p.116-126
Hauptverfasser:	Stalbow, Lauren A., Preuss, Michael H., Smit, Roelof A. J., Chami, Nathalie, Bjørkhaug, Lise, Aukrust, Ingvild, Gloyn, Anna L., Loos, Ruth J. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Biobanks Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - genetics Diagnosis Gene frequency Genome-wide association studies Genome-Wide Association Study Genomes Hepatocyte Nuclear Factor 1-alpha - genetics Hispanic Americans Human Physiology Humans Internal Medicine Medical diagnosis Medicine Medicine & Public Health Metabolic Diseases Population genetics Susceptibility
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