Biomimetic gasotransmitter-releasing alginate beads for biocompatible antimicrobial therapy

[Display omitted] •Sustained nitric oxide release for 24 h.•1-log reduction of E. coli and 3-log reduction of S. aureus after 24 h treatment.•Exceptional biocompatibility with no effect on fibroblast proliferation or migration. Hypothesis: Alginate is widely used in biomedical applications due to it...

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Veröffentlicht in:	Journal of colloid and interface science 2022-12, Vol.628 (Pt B), p.911-921
Hauptverfasser:	Estes Bright, Lori M., Griffin, Lauren, Mondal, Arnab, Hopkins, Sean, Ozkan, Ekrem, Handa, Hitesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Alginate alginates Alginates - chemistry Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Infective Agents antibiotic resistance Antimicrobial biocompatibility Biomimetics chemiluminescence Cross-Sectional Studies crosslinking cytotoxicity drug therapy drugs Endothelial Cells Escherichia coli fibroblasts Gasotransmitters Humans Hydrogel hydrogels Hydrogels - chemistry macrophages Mice Nitric oxide Nitric Oxide - metabolism Nitric Oxide Donors - chemistry Polymers - chemistry S-Nitrosoglutathione Staphylococcus aureus storage quality Water water solubility water uptake
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